| Tag | Content |
|---|---|
| Uniprot ID | A0A452GAY8 |
| Entrez ID | |
| Genbank protein ID | |
| Genbank nucleotide ID | |
| Ensembl protein ID | ENSCHIP00000033606 |
| Ensembl nucleotide ID | ENSCHIG00000027091 |
| Gene name | Uncharacterized protein |
| Gene symbol | PTPRS |
| Organism | Capra hircus |
| NCBI taxa ID | 9925 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | |
| Sequence | QSFPWGEGFL APLPLLSPEP PRFIKEPKDQ IGVSGGVASF VCQATGDPKP RVTWNKKGKK 60 VNSQRFETIE FDGSAGAVLR IQPLRTPRDE NVYECVAQNS VGEITVHAKL TVLREDQLPP 120 GFPNIDMGPQ LKVVERTRTA TMLCAASGNP DPEITWFKDF LPVDPSASNG RIKQLRSEST 180 PIRGKALSLQ IESSEETDQG KYECVATNSA GVRYSSPANL YVRVRRVAPR FSILPMSHEI 240 MPGGNVNITC VAVGSPMPYV KWMQGAEDLT PEDDMPVGRN VLELTDVKDS ANYTCVAMSS 300 LGVIEAVAQI TVKSLPKAPG TPVVTENTAT SITITWDSGN PDPVSYYVIE YKSKSQDGPY 360 QIKEDITTTR YSIGGLSPNS EYEIWVSAVN SIGQGPPSES VVTRTGEQAP ASAPRNVQAR 420 MLSATTMIIQ WEEPVEPNGL IRGYRIYYTM EPEHPVGNWQ KHNVDDSLLT TVGSLLEDET 480 YTVRVLAFTS VGDGPLSDPI QVKTQQGVPG QPMNFRAEAK SETSIGLSWS PPRQESIIKY 540 ELLYREGDHG REVARTFDPA TAFVVDDLKP NTEYAFRLAA RSPQGLGAFT SVVRQRTLQS 600 SSPPQDVKCV STRSTAILVS WRPPPPDTHN GALVSYSVRY RPLGSEDPQP KEVNGIPPTT 660 TQILLEALDK WTEYRITAVA HTEVGPGPES SPVVVRTDED VPSAPPRKVE AEALNATAIR 720 VLWRSPAPGR QHGQIRGYQV HYVRMEGAEA RGPPRIKDIM LADAQWETDD TAEYEMVITN 780 LQPETAYSIT VAAYTMKGDG ARSKPKVVVT KGAVLGRPTL SVQQTPEGSL LARWEPPAGA 840 TEDEVLGYRL QFGREDSSPL ATLEFPPTED HYTASGVHKG ATYVFRLAAR SRGGLGEEVA 900 EVLSIPEDTP RGHPQILEAA GNATAGTVLL RWLPPVPAER NGAIVKYTVA VREAGTLGPA 960 RETELPAAAE PGAENVLTLQ GLKPDTAYDL QVRAHTRRGP GPYSPPVRYR TFLRDQVSPK 1020 NFKVKMIMKT SVLLSWEFPD NYNSPTPYKI QYNGLTLDVD GRTTKKLITH LKPNTFYNFV 1080 LTNRGSSLGG LQQTVTAWTA FNLLSSKPSV TPKPDSDGFI VVYLPDGQSP VPVQNYFIVM 1140 VPLRKSRGGQ FLTPLGSPED MDLEELIQDI ARLQRRSLRH SRQLEVPRPY IAARFSVLPH 1200 TFHPGDQKQY GGFDNRGLEP GHRYVLFVLA VLQKSEPTFA ASPFSDPFQL DNPDPQPIVD 1260 GEEGLIWVIG PVLAVVFIIC IVIAILLYKN KRKDSEPRTK CLLNNADLAP HHPKDPVEMR 1320 RINFQTPDSG LSSPLREPGF HFESMLSHPP IPIGDMAEHT ERLKANDSLK LSQEYESIDP 1380 GQQFTWEHSN LEVNKPKNRY ANVIAYDHSR VILQPIEGIV GSDYINANYV DGYRRQNAYI 1440 ATQGPLPETF GDFWRMVWEQ RSATIVMMTR LEEKSRIKCD QYWPNRGTET YGFIQVTLLD 1500 TIELATFCVR TFSLHKNGSS EKREVRQFQF TAWPDHGVPE YPTPFLAFLR RVKTCNPPDA 1560 GPIVVHCSAG VGRTGCFIVI DAMLERIKPE KTVDVYGHVT LMRSQRNYMV QTEDQYSFIH 1620 EALLEAVGCG NTEVPARSLY AYIQKLTQVE PGEHVTGMEL EFKRLANSKA HTSRFISANL 1680 PCNKFKNRLV NIMPYESTRV CLQPIRGVEG SDYINASFID GYRQQKAYIA TQGPLAETTE 1740 DFWRMLWENN STIVVMLTKL REMGREKCHQ YWPAERSARY QYFVVDPMAE YNMPQYILRE 1800 FKVTDARDGQ SRTVRQFQFT DWPEQGVPKS GEGFIDFIGQ VHKTKEQFGQ DGPISVHCSA 1860 GVGRTGVFIT LSIVLERMRY EGVVDIFQTV KMLRTQRPAM VQMEDEYQFC YQAALEYLGS 1920 FDHYAT 1926 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | PTPRS | A0A452GAY8 | Capra hircus | Prediction | More>> | |||
| 1:1 ortholog | PTPRS | 5802 | Q13332 | Homo sapiens | Prediction | More>> | ||
| 1:1 ortholog | Ptprs | 19280 | B0V2N1 | CPO | Mus musculus | Publication | More>> | |
| 1:1 ortholog | Ptprs | M0R711 | Rattus norvegicus | Prediction | More>> | |||
| 1:1 ortholog | ptprsa | F1QLA4 | Danio rerio | Prediction | More>> |
| GO ID | GO Term |
|---|---|
| GO:0005829 | cytosol |
| GO:0098978 | glutamatergic synapse |
| GO:0099056 | integral component of presynaptic membrane |
| GO:0098685 | Schaffer collateral - CA1 synapse |
| GO:0035374 | chondroitin sulfate binding |
| GO:0008201 | heparin binding |
| GO:0004725 | protein tyrosine phosphatase activity |
| GO:0021549 | cerebellum development |
| GO:0021987 | cerebral cortex development |
| GO:0022038 | corpus callosum development |
| GO:0090557 | establishment of endothelial intestinal barrier |
| GO:0021766 | hippocampus development |
| GO:0050804 | modulation of chemical synaptic transmission |
| GO:0030517 | negative regulation of axon extension |
| GO:0048681 | negative regulation of axon regeneration |
| GO:0048671 | negative regulation of collateral sprouting |
| GO:0061000 | negative regulation of dendritic spine development |
| GO:0032687 | negative regulation of interferon-alpha production |
| GO:0032688 | negative regulation of interferon-beta production |
| GO:0034164 | negative regulation of toll-like receptor 9 signaling pathway |
| GO:0099151 | regulation of postsynaptic density assembly |
| GO:0021510 | spinal cord development |
| GO:0099560 | synaptic membrane adhesion |
| InterPro ID | InterPro Term |
|---|---|
| IPR003961 | FN3_dom |
| IPR036116 | FN3_sf |
| IPR007110 | Ig-like_dom |
| IPR036179 | Ig-like_dom_sf |
| IPR013783 | Ig-like_fold |
| IPR013098 | Ig_I-set |
| IPR003599 | Ig_sub |
| IPR003598 | Ig_sub2 |
| IPR029021 | Prot-tyrosine_phosphatase-like |
| IPR000242 | PTPase_domain |
| IPR016130 | Tyr_Pase_AS |
| IPR003595 | Tyr_Pase_cat |
| IPR000387 | TYR_PHOSPHATASE_dom |