| Tag | Content |
|---|---|
| Uniprot ID | B0V2N1; Q3TEC3; Q3TXC9; Q4JFC7; Q5XJV4; Q64503; Q64699; Q7TT17; |
| Entrez ID | 19280 |
| Genbank protein ID | AAH83188.1; AAH52462.1; BAE41325.1; CAA57732.1; BAA05886.1; BAE34987.1; |
| Genbank nucleotide ID | NM_011218.2; NM_001252456.1; NM_001252453.1; NM_001252455.1; |
| Ensembl protein ID | ENSMUSP00000153134; ENSMUSP00000064048; ENSMUSP00000084038; |
| Ensembl nucleotide ID | ENSMUSG00000013236 |
| Gene name | Receptor-type tyrosine-protein phosphatase S |
| Gene symbol | Ptprs |
| Organism | Mus musculus |
| NCBI taxa ID | 10090 |
| Cleft type | CPO |
| Developmental stage | |
| Data sources | Manually collected |
| Reference | 19273906; 23863482; |
| Functional description | Cell surface receptor that binds to glycosaminoglycans, including chondroitin sulfate proteoglycans and heparan sulfate proteoglycans (PubMed:19833921, PubMed:21454754, PubMed:22406547). Binding to chondroitin sulfate and heparan sulfate proteoglycans has opposite effects on PTPRS oligomerization and regulation of neurite outgrowth (PubMed:21454754). Contributes to the inhibition of neurite and axonal outgrowth by chondroitin sulfate proteoglycans, also after nerve transection (PubMed:15797710, PubMed:19833921, PubMed:19780196, PubMed:21454754, PubMed:22519304, PubMed:22406547). Plays a role in stimulating neurite outgrowth in response to the heparan sulfate proteoglycan GPC2 (PubMed:21454754). Required for normal brain development, especially for normal development of the pituitary gland and the olfactory bulb (PubMed:10080191). Functions as tyrosine phosphatase (PubMed:7529177). Mediates dephosphorylation of NTRK1, NTRK2 and NTRK3 (By similarity). Plays a role in down-regulation of signaling cascades that lead to the activation of Akt and MAP kinases (PubMed:15797710). Down-regulates TLR9-mediated activation of NF-kappa-B, as well as production of TNF, interferon alpha and interferon beta (PubMed:26231120). |
| Sequence | MAPTWSPSVV SVVGPVGLFL VLLARGCLAE EPPRFIREPK DQIGVSGGVA SFVCQATGDP 60 KPRVTWNKKG KKVNSQRFET IDFDESSGAV LRIQPLRTPR DENVYECVAQ NSVGEITIHA 120 KLTVLREDQL PPGFPNIDMG PQLKVVERTR TATMLCAASG NPDPEITWFK DFLPVDPSAS 180 NGRIKQLRSG ALQIESSEET DQGKYECVAT NSAGVRYSSP ANLYVRVRRV APRFSILPMS 240 HEIMPGGNVN ITCVAVGSPM PYVKWMQGAE DLTPEDDMPV GRNVLELTDV KDSANYTCVA 300 MSSLGVIEAV AQITVKSLPK APGTPVVTEN TATSITVTWD SGNPDPVSYY VIEYKSKSQD 360 GPYQIKEDIT TTRYSIGGLS PNSEYEIWVS AVNSIGQGPP SESVVTRTGE QAPASAPRNV 420 QARMLSATTM IVQWEEPVEP NGLIRGYRVY YTMEPEHPVG NWQKHNVDDS LLTTVGSLLE 480 DETYTVRVLA FTSVGDGPLS DPIQVKTQQG VPGQPMNLRA EAKSETSIGL SWSAPRQESV 540 IKYELLFREG DRGREVGRTF DPTTAFVVED LKPNTEYAFR LAARSPQGLG AFTAVVRQRT 600 LQAKPSAPPQ DVKCTSLRST AILVSWRPPP PETHNGALVG YSVRYRPLGS EDPDPKEVNN 660 IPPTTTQILL EALEKWTEYR VTAVAYTEVG PGPESSPVVV RTDEDVPSAP PRKVEAEALN 720 ATAIRVLWRS PTPGRQHGQI RGYQVHYVRM EGAEARGPPR IKDIMLADAQ EMVITNLQPE 780 TAYSITVAAY TMKGDGARSK PKVVVTKGAV LGRPTLSVQQ TPEGSLLARW EPPADAAEDP 840 VLGYRLQFGR EDAAPATLEL AAWERRFAAP AHKGATYVFR LAARGRAGLG EEAAAALSIP 900 EDAPRGFPQI LGAAGNVSAG SVLLRWLPPV PAERNGAIIK YTVSVREAGA PGPATETELA 960 AAAQPGAETA LTLRGLRPET AYELRVRAHT RRGPGPFSPP LRYRLARDPV SPKNFKVKMI 1020 MKTSVLLSWE FPDNYNSPTP YKIQYNGLTL DVDGRTTKKL ITHLKPHTFY NFVLTNRGSS 1080 LGGLQQTVTA RTAFNMLSGK PSVAPKPDND GFIVVYLPDG QSPVTVQNYF IVMVPLRKSR 1140 GGQFPVLLGS PEDMDLEELI QDISRLQRRS LRHSRQLEVP RPYIAARFSI LPAVFHPGNQ 1200 KQYGGFDNRG LEPGHRYVLF VLAVLQKNEP TFAASPFSDP FQLDNPDPQP IVDGEEGLIW 1260 VIGPVLAVVF IICIVIAILL YKNKPDSKRK DSEPRTKCLL NNADLAPHHP KDPVEMRRIN 1320 FQTPGMLSHP PIPITDMAEH MERLKANDSL KLSQEYESID PGQQFTWEHS NLEANKPKNR 1380 YANVIAYDHS RVILQPLEGI MGSDYINANY VDGYRRQNAY IATQGPLPET FGDFWRMVWE 1440 QRSATVVMMT RLEEKSRIKC DQYWPNRGTE TYGFIQVTLL DTMELATFCV RTFSLHKNGS 1500 SEKREVRHFQ FTAWPDHGVP EYPTPFLAFL RRVKTCNPPD AGPIVVHCSA GVGRTGCFIV 1560 IDAMLERIKT EKTVDVYGHV TLMRSQRNYM VQTEDQYGFI HEALLEAVGC GNTEVPARSL 1620 YTYIQKLAQV EPGEHVTGME LEFKRLASSK AHTSRFITAS LPCNKFKNRL VNILPYESSR 1680 VCLQPIRGVE GSDYINASFI DGYRQQKAYI ATQGPLAETT EDFWRALWEN NSTIVVMLTK 1740 LREMGREKCH QYWPAERSAR YQYFVVDPMA EYNMPQYILR EFKVTDARDG QSRTVRQFQF 1800 TDWPEQGAPK SGEGFIDFIG QVHKTKEQFG QDGPISVHCS AGVGRTGVFI TLSIVLERMR 1860 YEGVVDIFQT VKVLRTQRPA MVQTEDEYQF CFQAALEYLG SFDHYAT 1907 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | PTPRS | A0A452GAY8 | Capra hircus | Prediction | More>> | |||
| 1:1 ortholog | PTPRS | 5802 | Q13332 | Homo sapiens | Prediction | More>> | ||
| 1:1 ortholog | Ptprs | 19280 | B0V2N1 | CPO | Mus musculus | Publication | More>> | |
| 1:1 ortholog | Ptprs | M0R711 | Rattus norvegicus | Prediction | More>> | |||
| 1:1 ortholog | ptprsa | F1QLA4 | Danio rerio | Prediction | More>> |
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0004721 | phosphoprotein phosphatase activity | ISO |
| GO:0004725 | protein tyrosine phosphatase activity | ISO |
| GO:0004725 | protein tyrosine phosphatase activity | IBA |
| GO:0004725 | protein tyrosine phosphatase activity | IDA |
| GO:0005515 | protein binding | IPI |
| GO:0008201 | heparin binding | IDA |
| GO:0035374 | chondroitin sulfate binding | IDA |
| GO:0043395 | heparan sulfate proteoglycan binding | ISS |
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0006470 | protein dephosphorylation | ISO |
| GO:0006470 | protein dephosphorylation | IBA |
| GO:0010977 | negative regulation of neuron projection development | IMP |
| GO:0021510 | spinal cord development | IMP |
| GO:0021549 | cerebellum development | IMP |
| GO:0021766 | hippocampus development | IMP |
| GO:0021987 | cerebral cortex development | IMP |
| GO:0022038 | corpus callosum development | IMP |
| GO:0030517 | negative regulation of axon extension | IMP |
| GO:0032687 | negative regulation of interferon-alpha production | ISO |
| GO:0032688 | negative regulation of interferon-beta production | ISO |
| GO:0034164 | negative regulation of toll-like receptor 9 signaling pathway | ISO |
| GO:0035335 | peptidyl-tyrosine dephosphorylation | IMP |
| GO:0035335 | peptidyl-tyrosine dephosphorylation | IDA |
| GO:0048671 | negative regulation of collateral sprouting | IMP |
| GO:0048681 | negative regulation of axon regeneration | IMP |
| GO:0050804 | modulation of chemical synaptic transmission | IMP |
| GO:0050808 | synapse organization | IDA |
| GO:0050808 | synapse organization | IMP |
| GO:0061000 | negative regulation of dendritic spine development | IMP |
| GO:0090557 | establishment of endothelial intestinal barrier | IMP |
| GO:0099151 | regulation of postsynaptic density assembly | ISO |
| GO:0099151 | regulation of postsynaptic density assembly | IDA |
| GO:0099151 | regulation of postsynaptic density assembly | IMP |
| GO:0099560 | synaptic membrane adhesion | ISO |
| GO:0099560 | synaptic membrane adhesion | IBA |
| GO:1905606 | regulation of presynapse assembly | ISO |
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0005829 | cytosol | ISO |
| GO:0005886 | plasma membrane | ISO |
| GO:0005886 | plasma membrane | IDA |
| GO:0030054 | cell junction | IEA |
| GO:0030285 | integral component of synaptic vesicle membrane | ISS |
| GO:0030285 | integral component of synaptic vesicle membrane | ISO |
| GO:0030424 | axon | ISS |
| GO:0030426 | growth cone | IEA |
| GO:0043204 | perikaryon | IEA |
| GO:0098685 | Schaffer collateral - CA1 synapse | IDA |
| GO:0098685 | Schaffer collateral - CA1 synapse | IMP |
| GO:0098978 | glutamatergic synapse | ISO |
| GO:0098978 | glutamatergic synapse | IDA |
| GO:0098978 | glutamatergic synapse | IMP |
| GO:0099056 | integral component of presynaptic membrane | ISO |
| GO:0099056 | integral component of presynaptic membrane | IDA |
| GO:0099061 | integral component of postsynaptic density membrane | ISS |
| GO:0099061 | integral component of postsynaptic density membrane | ISO |
| Reactome ID | Reactome Term | Evidence |
|---|---|---|
| R-MMU-112316 | Neuronal System | IEA |
| R-MMU-388844 | Receptor-type tyrosine-protein phosphatases | IEA |
| R-MMU-6794362 | Protein-protein interactions at synapses | IEA |
| R-MMU-8849932 | Synaptic adhesion-like molecules | IEA |
| Keyword ID | Keyword Term |
|---|---|
| KW-0002 | 3D-structure |
| KW-0025 | Alternative splicing |
| KW-0130 | Cell adhesion |
| KW-0965 | Cell junction |
| KW-1003 | Cell membrane |
| KW-0966 | Cell projection |
| KW-0968 | Cytoplasmic vesicle |
| KW-1015 | Disulfide bond |
| KW-0325 | Glycoprotein |
| KW-0358 | Heparin-binding |
| KW-0378 | Hydrolase |
| KW-0393 | Immunoglobulin domain |
| KW-0472 | Membrane |
| KW-0904 | Protein phosphatase |
| KW-0675 | Receptor |
| KW-1185 | Reference proteome |
| KW-0677 | Repeat |
| KW-0732 | Signal |
| KW-0770 | Synapse |
| KW-0771 | Synaptosome |
| KW-0812 | Transmembrane |
| KW-1133 | Transmembrane helix |
| InterPro ID | InterPro Term |
|---|---|
| IPR003961 | FN3_dom |
| IPR036116 | FN3_sf |
| IPR007110 | Ig-like_dom |
| IPR036179 | Ig-like_dom_sf |
| IPR013783 | Ig-like_fold |
| IPR013098 | Ig_I-set |
| IPR003599 | Ig_sub |
| IPR003598 | Ig_sub2 |
| IPR029021 | Prot-tyrosine_phosphatase-like |
| IPR000242 | PTPase_domain |
| IPR016130 | Tyr_Pase_AS |
| IPR003595 | Tyr_Pase_cat |
| IPR000387 | TYR_PHOSPHATASE_dom |