| Tag | Content |
|---|---|
| Uniprot ID | M0R711 |
| Entrez ID | |
| Genbank protein ID | |
| Genbank nucleotide ID | |
| Ensembl protein ID | ENSRNOP00000065227 |
| Ensembl nucleotide ID | ENSRNOG00000047247 |
| Gene name | Receptor-type tyrosine-protein phosphatase S |
| Gene symbol | Ptprs |
| Organism | Rattus norvegicus |
| NCBI taxa ID | 10116 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | |
| Sequence | MAPTWRPSVV SVVGPVGLFL VLLARGCLAE EPPRFIREPK DQIGVSGGVA SFVCQATGDP 60 KPRVTWNKKG KKVNSQRFET IDFDESSGAV LRIQPLRTPR DENVYECVAQ NSVGEITVHA 120 KLTVLREDQL PPGFPNIDMG PQLKVVERTR TATMLCAASG NPDPEITWFK DFLPVDPSAS 180 NGRIKQLRSG ALQIESSEET DQGKYECVAT NSAGVRYSSP ANLYVRVRRV APRFSILPMS 240 HEIMPGGNVN ITCVAVGSPM PYVKWMQGAE DLTPEDDMPV GRNVLELTDV KDSANYTCVA 300 MSSLGVIEAV AQITVKSLPK APGTPVVTEN TATSITVTWD SGNPDPVSYY VIEYKSKSQD 360 GPYQIKEDIT TTRYSIGGLS PNSEYEIWVS AVNSIGQGPP SESVVTRTGE QAPASPRNVQ 420 ARMLSATTMI VQWEPVEPNG LILHRVYYTM EPEHPGNWQK HNVTTVFWDH LWAACLEDET 480 YTVRVLGLHI VGDGPLSDPI QVKDPQQVPG RPLNMRGADK AETSMGSVMS PREKWSLYEL 540 PSWGGHRMAR EVGRTFDPTT AFVVEDLKPN TEYAFRLAAR SPQGLGAFTA VVRQRTLQAK 600 PSAPPQDVKC TSLRSTAILV SWRPPPPETH NGALVGYSVR YRPLGSEDPD PKEVNNIPPT 660 TTQILLEALE KWTEYRVTAV AYTEVGPGPE SSPVVVRTDE DVPSAPPRKV EAEALNATAI 720 RVLWRSPTPG RQHGQIRGYQ VHYVRMEGAE ARGPPRIKDI MLADAQEMVI TNLQPETAYS 780 ITVAAYTMKG DGARSKPKVV VTKGAVLGRP TLSVQQTPEG SLLARWEPPA DAAEDPVLGY 840 RLQFGREDAA PATLELAAWE RRFAAPAHKG ATYVFRLAAR GRAGLGEEAS AALSIPEDAP 900 RGFPQILGAA GNVSAGSVIL RWLPPVPAER NGAIIKYTVS VREAGAPGPA TETELAAAAQ 960 PGAETALTLQ GLRPETAYEL RVRAHTRRGP GPFSPPLRYR LARDPVSPKN FKVKMIMKTS 1020 VLLSWEFPDN YNSPTPYKIQ YNGLTLDVDG RTTKKLITHL KPHTFYNFVL TNRGSSLGGL 1080 QQTVTARTAF NMLSGKPSVA PKPDNDGSIV VYLPDGQSPV TVQNYFIVMV PLRKSRGGQF 1140 PILLGSPEDM DLEELIQDLS RLQRRSLRHS RQLEVPRPYI AARFSILPAV FHPGNQKQYG 1200 GFDNRGLEPG HRYVLFVLAV LQKNEPTFAA SPFSDPFQLD NPDPQPIVDG EEGLIWVIGP 1260 VLAVVFIICI VIAILLYKNK PDSKRKDSEP RTKCLLNNAD LAPHHPKDPV EMRRINFQTP 1320 GMLSHPPIPI TDMAEHMERL KANDSLKLSQ EYESIDPGQQ FTWEHSNLEA NKPKNRYANV 1380 IAYDHSRVIL QPLEGIMGSD YINANYVDGY RRQNAYIATQ GPLPETFGDF WRMVWEQRSA 1440 TVVMMTRLEE KSRVKCDQYW PNRGTETYGF IQVTLLDTME LATFCVRTFS LHKNGSSEKR 1500 EVRHFQFTAW PDHGVPEYPT PFLAFLRRVK TCNPPDAGPV VVHCSAGVGR TGCFIVIDAM 1560 LERIRTEKTV DVYGHVTLMR SQRNYMVQTE DQYSFIHEAL LEAVGCGNTE VPARSLYTYI 1620 QKLAQVEPGE HVTGMELEFK RLASSKAHTS RFITASLPCN KFKNRLVNIL PYESSRVCLQ 1680 PIRGVEGSDY INASFIDGYR QQKAYIATQG PLAETTEDFW RALWENNSTI VVMLTKLREM 1740 GREKCHQYWP AERSARYQYF VVDPMAEYNM PQYILREFKV TDARDGQSRT VRQFQFTDWP 1800 EQGAPKSGEG FIDFIGQVHK TKEQFGQDGP ISVHCSAGVG RTGVFITLSI VLERMRYEGV 1860 VDIFQTVKVL RTQRPAMVQT EDEYQFCFQA ALEYLGSFDH YAT 1903 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | PTPRS | A0A452GAY8 | Capra hircus | Prediction | More>> | |||
| 1:1 ortholog | PTPRS | 5802 | Q13332 | Homo sapiens | Prediction | More>> | ||
| 1:1 ortholog | Ptprs | 19280 | B0V2N1 | CPO | Mus musculus | Publication | More>> | |
| 1:1 ortholog | Ptprs | M0R711 | Rattus norvegicus | Prediction | More>> | |||
| 1:1 ortholog | ptprsa | F1QLA4 | Danio rerio | Prediction | More>> |
| GO ID | GO Term |
|---|---|
| GO:0005829 | cytosol |
| GO:0098978 | glutamatergic synapse |
| GO:0099056 | integral component of presynaptic membrane |
| GO:0098685 | Schaffer collateral - CA1 synapse |
| GO:0035374 | chondroitin sulfate binding |
| GO:0008201 | heparin binding |
| GO:0004725 | protein tyrosine phosphatase activity |
| GO:0021549 | cerebellum development |
| GO:0021987 | cerebral cortex development |
| GO:0022038 | corpus callosum development |
| GO:0090557 | establishment of endothelial intestinal barrier |
| GO:0021766 | hippocampus development |
| GO:0050804 | modulation of chemical synaptic transmission |
| GO:0030517 | negative regulation of axon extension |
| GO:0048681 | negative regulation of axon regeneration |
| GO:0048671 | negative regulation of collateral sprouting |
| GO:0061000 | negative regulation of dendritic spine development |
| GO:0032687 | negative regulation of interferon-alpha production |
| GO:0032688 | negative regulation of interferon-beta production |
| GO:0034164 | negative regulation of toll-like receptor 9 signaling pathway |
| GO:0099151 | regulation of postsynaptic density assembly |
| GO:0021510 | spinal cord development |
| GO:0099560 | synaptic membrane adhesion |
| InterPro ID | InterPro Term |
|---|---|
| IPR003961 | FN3_dom |
| IPR036116 | FN3_sf |
| IPR007110 | Ig-like_dom |
| IPR036179 | Ig-like_dom_sf |
| IPR013783 | Ig-like_fold |
| IPR013098 | Ig_I-set |
| IPR003599 | Ig_sub |
| IPR003598 | Ig_sub2 |
| IPR029021 | Prot-tyrosine_phosphatase-like |
| IPR000242 | PTPase_domain |
| IPR016130 | Tyr_Pase_AS |
| IPR003595 | Tyr_Pase_cat |
| IPR000387 | TYR_PHOSPHATASE_dom |