Gene: ptprsa

Basic information

Tag Content
Uniprot ID F1QLA4
Entrez ID
Genbank protein ID
Genbank nucleotide ID
Ensembl protein ID ENSDARP00000118236
Ensembl nucleotide ID ENSDARG00000059738
Gene name Protein-tyrosine-phosphatase
Gene symbol ptprsa
Organism Danio rerio
NCBI taxa ID 7955
Cleft type
Developmental stage
Data sources Homology search
Reference
Functional description
Sequence
MSKPSCPSSE LTSKLFFPTE DLLPPGFPNI DMGPQLKVVE RTRTATMLCA ASGNPDPEIT 60
WFKDFLPIDP NTSNGRIKQL RSGALQIENT EETDQGKYEC VASNVEGVRY SSPANLYVRV 120
RRVPPRFSIL PTSQEIMPGG SVNITCVAVG SPMPYVKWML NSEDLTPEDE MPVGRNVLEL 180
NSVRESANYT CVAMSSLGII ETVAQITVKS LPKPPGTPVV TETTATSITI TWDSGNPEPV 240
SHYIIQYRAK SPESKFETVD SITTTRYSIG GLSPNTDYEI RVSAFNTIGQ GPPSEPVEAR 300
TGEQAPASPP RNIQARIISQ NTVLVRWDEP DEPNGQIKGY RVYYTMDPTL PMSMWQIHNV 360
QDSVLTTIQS LVTSETYTIR VLAFTSVGDG PFSDPIHVKV LQGVPGQPTN FQVGEVSDTG 420
VELTWEPAFE KEGIISYELH YKEGKDGPLG KKKFAPTSSF VVDGLRPNTE YFFSLAAVSS 480
KGIGAFTNDL AQTTSQAKPS APPQDIKCSS SSSTVLMVSW RPPPAESQNG ELAGYIVRYA 540
VVGAGAEVST EHVEAPTSDQ ILLQRLEKWT MYRVTVAAST SVGSGPESEP LLCRTDEDVP 600
GAPPRRVEVE VLNSTAIKVM WRSLLPGKQH GQIRGYQVHY VRVENGESRG LPLIKDVMLA 660
DAQEMVIGGL QPDTTYSITV AAYTTKGDGA RSKPKLVLTK GAVPGPPFLS VNQNSESTAI 720
IRWQPPDYVA PGLEVQGYRL QFGRKDVNPL ATLEFGPQEL EYSISNIHRG ATYIFKVSAK 780
SKSGFGEEAT QELRVPEEVP RGYPQITEGS NITCCSVQFS WLPPVLAERN GAITEYTLSY 840
QEAGTISGPK ELRLPADENS YILNSLRPNA VYDVKIRAHT SVGPGPYSPP IQYRTVAYEA 900
DVPRNFTVKL VTKTTVLLSW KFYDSRFPYK CTIEYHRQKS DIDARMTKTL ITNLRPNTTY 960
EFRISCQDSS DGGPKHKLVA RTAPHIQIRK PELDLKRESE STLTIVFPPL ETKDLIKAIY 1020
VVVVPLKKGK GPMRHIKSPD ELDLEELLGE RRLGLHHSGT TRQLKQVDGK RPYIAASFKP 1080
SSMPPSFTLG NQMMYGSFEN RALDRGQEYV LFILAELNTT GVKAFVSSPY TDPIMAPDLD 1140
PQPLESGGDG LIWVVGPVLA VVFIICIVIA ILLYKNSKRK ESEPRTKCLL NNADITPHHP 1200
TDPVEMRRIN FQTPGMMNHP PIPISELAEH TELLKANDNL KLSQEYESID PGQQFTWEHS 1260
NLEVNKPKNR YANVIAYDHS RVILAPIEGI TGSDYINSNY IDGYRKQNAY IATQGPLPET 1320
FGDFWRMVWE QRAATVVMMT RLEEKSRIKC DQYWPSRGTE TYGMIQVTLL DTIELATFCV 1380
RTFSLHKNGS SEKREVRQFQ FTAWPDHGVP EYPTPFLAFL RRVKTCNPPD AGPIIAHCSA 1440
GVGRTGCFIV IDAMLERIKH EKTVDIYGHV TLMRSQRNYM VQTEDQYSFI HDALLEAVAC 1500
GNTEVAARSL FSYIQKLAQV EAGEHVSGME LEFKRLANSK AHTSRFISAN LPCNKFKNRL 1560
VNIMPYETTR VCLQPIRGLE GSDYINSSFI DGYRQQKAYI ATQGPLAETT EDFWRMLWEN 1620
NSTIVVMLTK LREMGREKCH QYWPAERSAR YQYFVVDPMA EYNMPQYILR EFKVTDARDG 1680
QSRTVRQFQF TDWPEQGVPK SGEGFIDFIG QVHKTKEQFG QDGPISVHCS AGVGRTGVFI 1740
TLSIVLERMR YEGVVDIFQT VKMLRTQRPA MVQTEDEYQF CYQAALEYLG SFDHYAT 1797

Abbreviation :
CLO : cleft lip only. CPO : cleft palate only. CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.

Protein disorder information

Orthologous information

Relation Gene symbol Entrez ID UniProt ID Cleft type Developmental stage Species Evidence Details
1:1 orthologPTPRSA0A452GAY8Capra hircusPredictionMore>>
1:1 orthologPTPRS5802Q13332Homo sapiensPredictionMore>>
1:1 orthologPtprs19280B0V2N1CPOMus musculusPublicationMore>>
1:1 orthologPtprsM0R711Rattus norvegicusPredictionMore>>
1:1 orthologptprsaF1QLA4Danio rerioPredictionMore>>

Gene ontology

GO ID GO Term
GO:0016021 integral component of membrane
GO:0004725 protein tyrosine phosphatase activity
GO:0021772 olfactory bulb development
GO:0006470 protein dephosphorylation
GO:0099560 synaptic membrane adhesion

Functional annotations

Keywords

Keyword ID Keyword Term
KW-0325 Glycoprotein
KW-0378 Hydrolase
KW-0393 Immunoglobulin domain
KW-0472 Membrane
KW-0904 Protein phosphatase
KW-1267 Proteomics identification
KW-0675 Receptor
KW-1185 Reference proteome
KW-0677 Repeat
KW-0732 Signal
KW-0812 Transmembrane
KW-1133 Transmembrane helix

Interpro

InterPro ID InterPro Term
IPR003961 FN3_dom
IPR036116 FN3_sf
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003599 Ig_sub
IPR003598 Ig_sub2
IPR029021 Prot-tyrosine_phosphatase-like
IPR000242 PTPase_domain
IPR016130 Tyr_Pase_AS
IPR003595 Tyr_Pase_cat
IPR000387 TYR_PHOSPHATASE_dom

PROSITE

PROSITE ID PROSITE Term
PS50853 FN3
PS50835 IG_LIKE
PS00383 TYR_PHOSPHATASE_1
PS50056 TYR_PHOSPHATASE_2
PS50055 TYR_PHOSPHATASE_PTP

Pfam

Pfam ID Pfam Term
PF00041 fn3
PF00102 Y_phosphatase