Gene: PRRX1

Basic information

Tag Content
Uniprot ID A0A5F4C613
Entrez ID 609105
Genbank protein ID
Genbank nucleotide ID XM_845632.4
Ensembl protein ID ENSCAFP00000049671
Ensembl nucleotide ID ENSCAFG00000015002
Gene name Paired related homeobox 1
Gene symbol PRRX1
Organism Canis lupus familiaris
NCBI taxa ID 9615
Cleft type
Developmental stage
Data sources Homology search
Reference
Functional description
Sequence
MTSSYGHVLE RQPALGGRLD SPGNLDTLQA KKNFSVSHLL DLEEAGDMVA AQADESVGEA 60
GRSLLESPGL TSGSDTPQQD NDQLNSEEKK KRKQRRNRTT FNSSQLQALE RVFERTHYPD 120
AFVREDLARR VNLTEARVQV WFQNRRAKFR RNERAMLANK NASLLKSYSG DVTAVEQPIV 180
PRPAPRPTDY LSWGTASPYS AMATYSATCA NNSPAQGINM ANSIANLRLK AKEYSLQRNQ 240
VPTVN 245

Abbreviation :
CLO : cleft lip only. CPO : cleft palate only. CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.

Protein disorder information

Orthologous information

Relation Gene symbol Entrez ID UniProt ID Cleft type Developmental stage Species Evidence Details
1:1 orthologPRRX1540901A2VE85Bos taurusPredictionMore>>
1:1 orthologPRRX1609105A0A5F4C613Canis lupus familiarisPredictionMore>>
1:1 orthologPRRX1102190342A0A452E2W3Capra hircusPredictionMore>>
1:1 orthologPRRX1F6WAC4Equus caballusPredictionMore>>
1:1 orthologPRRX15396P54821Homo sapiensPredictionMore>>
1:1 orthologPrrx118933P63013CPOE14.5, E16.5Mus musculusPublicationMore>>
1:1 orthologPRRX1736677H2Q0L1Pan troglodytesPredictionMore>>
1:1 orthologPRRX1A0A287A1I3Sus scrofaPredictionMore>>
1:1 orthologPRRX1G1T2Y3Oryctolagus cuniculusPredictionMore>>
1:1 orthologPrrx1266813P63014Rattus norvegicusPredictionMore>>

Gene ontology

GO ID GO Term
GO:0005634 nucleus
GO:0043565 sequence-specific DNA binding
GO:0007275 multicellular organism development
GO:0006355 regulation of transcription, DNA-templated

Functional annotations

Keywords

Keyword ID Keyword Term
KW-0217 Developmental protein
KW-0238 DNA-binding
KW-0371 Homeobox
KW-0539 Nucleus
KW-1185 Reference proteome

Interpro

InterPro ID InterPro Term
IPR009057 Homeobox-like_sf
IPR017970 Homeobox_CS
IPR001356 Homeobox_dom
IPR003654 OAR_dom
IPR043378 PRRX1/2

PROSITE

PROSITE ID PROSITE Term
PS00027 HOMEOBOX_1
PS50071 HOMEOBOX_2
PS50803 OAR

Pfam

Pfam ID Pfam Term
PF00046 Homeodomain
PF03826 OAR