| Tag | Content |
|---|---|
| Uniprot ID | G1T2Y3 |
| Entrez ID | |
| Genbank protein ID | |
| Genbank nucleotide ID | |
| Ensembl protein ID | ENSOCUP00000010561 |
| Ensembl nucleotide ID | ENSOCUG00000012272 |
| Gene name | Paired related homeobox 1 |
| Gene symbol | PRRX1 |
| Organism | Oryctolagus cuniculus |
| NCBI taxa ID | 9986 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | |
| Sequence | MGGWRAPCPR LSPRDRPHPG WTQTRAVSPS PPLPLGGRTP GLGVVAGESD LGHTKEVTKL 60 AGAKKNFSVS HLLDLEEAGD MVAAQADESV GEAGRSLLES PGLTSGSDTP QQDNDQLNSE 120 EKKKRKQRRN RTTFNSSQLQ ALERVFERTH YPDAFVREDL ARRVNLTEAR VQVWFQNRRA 180 KFRRNERAML ANKNASLLKS YSGDVTAVEQ PIVPRPAPRP TDYLSWGTAS PYSAMATYSA 240 TCANNSPAQG INMANSIANL RLKAKEYSLQ RNQVPTVN 278 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | PRRX1 | 540901 | A2VE85 | Bos taurus | Prediction | More>> | ||
| 1:1 ortholog | PRRX1 | 609105 | A0A5F4C613 | Canis lupus familiaris | Prediction | More>> | ||
| 1:1 ortholog | PRRX1 | 102190342 | A0A452E2W3 | Capra hircus | Prediction | More>> | ||
| 1:1 ortholog | PRRX1 | F6WAC4 | Equus caballus | Prediction | More>> | |||
| 1:1 ortholog | PRRX1 | 5396 | P54821 | Homo sapiens | Prediction | More>> | ||
| 1:1 ortholog | Prrx1 | 18933 | P63013 | CPO | E14.5, E16.5 | Mus musculus | Publication | More>> |
| 1:1 ortholog | PRRX1 | 736677 | H2Q0L1 | Pan troglodytes | Prediction | More>> | ||
| 1:1 ortholog | PRRX1 | A0A287A1I3 | Sus scrofa | Prediction | More>> | |||
| 1:1 ortholog | PRRX1 | G1T2Y3 | Oryctolagus cuniculus | Prediction | More>> | |||
| 1:1 ortholog | Prrx1 | 266813 | P63014 | Rattus norvegicus | Prediction | More>> |
| GO ID | GO Term |
|---|---|
| GO:0005829 | cytosol |
| GO:0005654 | nucleoplasm |
| GO:0001227 | DNA-binding transcription repressor activity, RNA polymerase II-specific |
| GO:0071837 | HMG box domain binding |
| GO:0000978 | RNA polymerase II cis-regulatory region sequence-specific DNA binding |
| GO:0003713 | transcription coactivator activity |
| GO:0048844 | artery morphogenesis |
| GO:0051216 | cartilage development |
| GO:0048701 | embryonic cranial skeleton morphogenesis |
| GO:0030326 | embryonic limb morphogenesis |
| GO:0042472 | inner ear morphogenesis |
| GO:0042474 | middle ear morphogenesis |
| GO:0048664 | neuron fate determination |
| GO:0097150 | neuronal stem cell population maintenance |
| GO:0002053 | positive regulation of mesenchymal cell proliferation |
| GO:0045880 | positive regulation of smoothened signaling pathway |
| GO:0045944 | positive regulation of transcription by RNA polymerase II |
| GO:0070570 | regulation of neuron projection regeneration |
| GO:0060021 | roof of mouth development |