| Tag | Content |
|---|---|
| Uniprot ID | P63013; P43271; Q02810; Q569N6; |
| Entrez ID | 18933 |
| Genbank protein ID | AAH92372.1; AAC52139.1; CAA42410.1; AAA39672.1; |
| Genbank nucleotide ID | NM_175686.3; NM_011127.2; XM_006496703.3; |
| Ensembl protein ID | ENSMUSP00000027878; ENSMUSP00000075203; |
| Ensembl nucleotide ID | ENSMUSG00000026586 |
| Gene name | Paired mesoderm homeobox protein 1 |
| Gene symbol | Prrx1 |
| Organism | Mus musculus |
| NCBI taxa ID | 10090 |
| Cleft type | CPO |
| Developmental stage | E14.5, E16.5 |
| Data sources | Manually collected |
| Reference | 9876178; 9729491; 7758948; |
| Functional description | Acts as a transcriptional regulator of muscle creatine kinase (MCK) and so has a role in the establishment of diverse mesodermal muscle types. The protein binds to an A/T-rich element in the muscle creatine enhancer. |
| Sequence | MTSSYGHVLE RQPALGGRLD SPGNLDTLQA KKNFSVSHLL DLEEAGDMVA AQADESVGEA 60 GRSLLESPGL TSGSDTPQQD NDQLNSEEKK KRKQRRNRTT FNSSQLQALE RVFERTHYPD 120 AFVREDLARR VNLTEARVQV WFQNRRAKFR RNERAMLANK NASLLKSYSG DVTAVEQPIV 180 PRPAPRPTDY LSWGTASPYS AMATYSATCA NNSPAQGINM ANSIANLRLK AKEYSLQRNQ 240 VPTVN 245 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | PRRX1 | 540901 | A2VE85 | Bos taurus | Prediction | More>> | ||
| 1:1 ortholog | PRRX1 | 609105 | A0A5F4C613 | Canis lupus familiaris | Prediction | More>> | ||
| 1:1 ortholog | PRRX1 | 102190342 | A0A452E2W3 | Capra hircus | Prediction | More>> | ||
| 1:1 ortholog | PRRX1 | F6WAC4 | Equus caballus | Prediction | More>> | |||
| 1:1 ortholog | PRRX1 | 5396 | P54821 | Homo sapiens | Prediction | More>> | ||
| 1:1 ortholog | Prrx1 | 18933 | P63013 | CPO | E14.5, E16.5 | Mus musculus | Publication | More>> |
| 1:1 ortholog | PRRX1 | 736677 | H2Q0L1 | Pan troglodytes | Prediction | More>> | ||
| 1:1 ortholog | PRRX1 | A0A287A1I3 | Sus scrofa | Prediction | More>> | |||
| 1:1 ortholog | PRRX1 | G1T2Y3 | Oryctolagus cuniculus | Prediction | More>> | |||
| 1:1 ortholog | Prrx1 | 266813 | P63014 | Rattus norvegicus | Prediction | More>> |
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0000978 | RNA polymerase II cis-regulatory region sequence-specific DNA binding | IDA |
| GO:0001227 | DNA-binding transcription repressor activity, RNA polymerase II-specific | IDA |
| GO:0003677 | DNA binding | IDA |
| GO:0003713 | transcription coactivator activity | IDA |
| GO:0071837 | HMG box domain binding | IPI |
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0000122 | negative regulation of transcription by RNA polymerase II | ISO |
| GO:0000122 | negative regulation of transcription by RNA polymerase II | IDA |
| GO:0002053 | positive regulation of mesenchymal cell proliferation | IGI |
| GO:0030326 | embryonic limb morphogenesis | IGI |
| GO:0042472 | inner ear morphogenesis | IGI |
| GO:0042474 | middle ear morphogenesis | IMP |
| GO:0042474 | middle ear morphogenesis | IGI |
| GO:0045880 | positive regulation of smoothened signaling pathway | IGI |
| GO:0045944 | positive regulation of transcription by RNA polymerase II | IDA |
| GO:0048664 | neuron fate determination | IDA |
| GO:0048701 | embryonic cranial skeleton morphogenesis | IMP |
| GO:0048701 | embryonic cranial skeleton morphogenesis | IGI |
| GO:0048704 | embryonic skeletal system morphogenesis | IGI |
| GO:0048704 | embryonic skeletal system morphogenesis | IMP |
| GO:0048844 | artery morphogenesis | IGI |
| GO:0048844 | artery morphogenesis | IMP |
| GO:0051216 | cartilage development | IMP |
| GO:0051216 | cartilage development | IGI |
| GO:0060021 | roof of mouth development | IMP |
| GO:0070570 | regulation of neuron projection regeneration | IMP |
| GO:0097150 | neuronal stem cell population maintenance | IDA |
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0005634 | nucleus | IDA |
| GO:0005654 | nucleoplasm | ISO |
| GO:0005829 | cytosol | ISO |
| Reactome ID | Reactome Term | Evidence |
|---|