| Tag | Content |
|---|---|
| Uniprot ID | P63014; P43271; Q02810; Q643W9; |
| Entrez ID | 266813 |
| Genbank protein ID | AAU21314.1; EDM09378.1; AAB46839.1; |
| Genbank nucleotide ID | NM_153821.1; XM_006250151.3; |
| Ensembl protein ID | ENSRNOP00000004950; ENSRNOP00000075169; |
| Ensembl nucleotide ID | ENSRNOG00000003720 |
| Gene name | Paired mesoderm homeobox protein 1 |
| Gene symbol | Prrx1 |
| Organism | Rattus norvegicus |
| NCBI taxa ID | 10116 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | Acts as a transcriptional regulator of muscle creatine kinase (MCK) and so has a role in the establishment of diverse mesodermal muscle types. The protein binds to an A/T-rich element in the muscle creatine enhancer (By similarity). |
| Sequence | MTSSYGHVLE RQPALGGRLD SPGNLDTLQA KKNFSVSHLL DLEEAGDMVA AQADESVGEA 60 GRSLLESPGL TSGSDTPQQD NDQLNSEEKK KRKQRRNRTT FNSSQLQALE RVFERTHYPD 120 AFVREDLARR VNLTEARVQV WFQNRRAKFR RNERAMLANK NASLLKSYSG DVTAVEQPIV 180 PRPAPRPTDY LSWGTASPYS AMATYSATCA NNSPAQGINM ANSIANLRLK AKEYSLQRNQ 240 VPTVN 245 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | PRRX1 | 540901 | A2VE85 | Bos taurus | Prediction | More>> | ||
| 1:1 ortholog | PRRX1 | 609105 | A0A5F4C613 | Canis lupus familiaris | Prediction | More>> | ||
| 1:1 ortholog | PRRX1 | 102190342 | A0A452E2W3 | Capra hircus | Prediction | More>> | ||
| 1:1 ortholog | PRRX1 | F6WAC4 | Equus caballus | Prediction | More>> | |||
| 1:1 ortholog | PRRX1 | 5396 | P54821 | Homo sapiens | Prediction | More>> | ||
| 1:1 ortholog | Prrx1 | 18933 | P63013 | CPO | E14.5, E16.5 | Mus musculus | Publication | More>> |
| 1:1 ortholog | PRRX1 | 736677 | H2Q0L1 | Pan troglodytes | Prediction | More>> | ||
| 1:1 ortholog | PRRX1 | A0A287A1I3 | Sus scrofa | Prediction | More>> | |||
| 1:1 ortholog | PRRX1 | G1T2Y3 | Oryctolagus cuniculus | Prediction | More>> | |||
| 1:1 ortholog | Prrx1 | 266813 | P63014 | Rattus norvegicus | Prediction | More>> |
| GO ID | GO Term |
|---|---|
| GO:0005829 | cytosol |
| GO:0005654 | nucleoplasm |
| GO:0005634 | nucleus |
| GO:0003677 | DNA binding |
| GO:0001227 | DNA-binding transcription repressor activity, RNA polymerase II-specific |
| GO:0071837 | HMG box domain binding |
| GO:0000978 | RNA polymerase II cis-regulatory region sequence-specific DNA binding |
| GO:0003713 | transcription coactivator activity |
| GO:0048844 | artery morphogenesis |
| GO:0051216 | cartilage development |
| GO:0048701 | embryonic cranial skeleton morphogenesis |
| GO:0030326 | embryonic limb morphogenesis |
| GO:0048704 | embryonic skeletal system morphogenesis |
| GO:0042472 | inner ear morphogenesis |
| GO:0042474 | middle ear morphogenesis |
| GO:0000122 | negative regulation of transcription by RNA polymerase II |
| GO:0048664 | neuron fate determination |
| GO:0097150 | neuronal stem cell population maintenance |
| GO:0002053 | positive regulation of mesenchymal cell proliferation |
| GO:0045880 | positive regulation of smoothened signaling pathway |
| GO:0045944 | positive regulation of transcription by RNA polymerase II |
| GO:0070570 | regulation of neuron projection regeneration |
| GO:0060021 | roof of mouth development |