| Tag | Content |
|---|---|
| Uniprot ID | A2RRV7 |
| Entrez ID | 558502 |
| Genbank protein ID | AAI31873.1 |
| Genbank nucleotide ID | NM_001083826.1 |
| Ensembl protein ID | ENSDARP00000073853 |
| Ensembl nucleotide ID | ENSDARG00000007231 |
| Gene name | Receptor-like tyrosine kinase |
| Gene symbol | ryk |
| Organism | Danio rerio |
| NCBI taxa ID | 7955 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | |
| Sequence | MFLPARGSVG GAASAVSRGW PHTVQWRLVG FFLLLLLEGA RCLANPSNSP GINNNNRPNV 60 NIFMSEEEVK KLLGLDAELY YVRDDVVNHY ALSFVLPVPS DTNSLHFTWH SSSKVDYRLG 120 FHVENTSAMD QPQSNISVQG EVPRTRSVFR VDLFCSGKAD GEAVLTVQLN LSTAANFTVL 180 NFKRRKMCYR RIEQPEPPKT LPFPNTTIQR IDASSPNAPT TSTRVFYISV CVCCIVIFLV 240 AIILAVLHLH SMKRVEMDDS VSDSGSSQGL SQPSTQTTQY LRADTPNNAT PVTSYPSLRI 300 EKNDLRSVTL LEAKAKVKDI AISRERVTLR DVLHEGTFGR IFHGVLLDEK DPSKEKQVFV 360 KAVKDHASEV QVTMMLTESC KLRGLHHRNL LPISHVCIED GEKPMVLLPY MNWGNLKLFL 420 RQCKLAEANN PQAISQQDLV HMAIQISCGM SYLARREVIH KDLAARNCVI DNSMQVKITD 480 NALARDLFPM DYHCLGDNEN RPVRWMALES LLNNDFSSAS DVWAFGVTLW ELMTLGQTPY 540 VDIDPFEMAA YLKDGYRIAQ PINCPDELFA VMACCWALDP EERPKFQQLV QCLTEFHAAL 600 GAYV 604 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | RYK | 102170271 | A0A452FRV1 | Capra hircus | Prediction | More>> | ||
| 1:1 ortholog | RYK | 6259 | P34925 | CPO,CL/P | Homo sapiens | Publication | More>> | |
| 1:1 ortholog | Ryk | 20187 | Q01887 | CPO | E14.5 | Mus musculus | Publication | More>> |
| 1:1 ortholog | RYK | 470931 | H2QNE9 | Pan troglodytes | Prediction | More>> | ||
| 1:1 ortholog | Ryk | F1LQR5 | Rattus norvegicus | Prediction | More>> | |||
| 1:1 ortholog | ryk | 558502 | A2RRV7 | Danio rerio | Prediction | More>> |
| GO ID | GO Term |
|---|---|
| GO:0005887 | integral component of plasma membrane |
| GO:0005886 | plasma membrane |
| GO:0043235 | receptor complex |
| GO:0005524 | ATP binding |
| GO:0004672 | protein kinase activity |
| GO:0017147 | Wnt-protein binding |
| GO:0007409 | axonogenesis |
| GO:0042074 | cell migration involved in gastrulation |
| GO:0060026 | convergent extension |
| GO:0060028 | convergent extension involved in axis elongation |
| GO:0060030 | dorsal convergence |
| GO:0007275 | multicellular organism development |
| GO:0018108 | peptidyl-tyrosine phosphorylation |
| GO:0033674 | positive regulation of kinase activity |
| GO:0051209 | release of sequestered calcium ion into cytosol |
| GO:0007169 | transmembrane receptor protein tyrosine kinase signaling pathway |
| GO:0007223 | Wnt signaling pathway, calcium modulating pathway |