| Tag | Content |
|---|---|
| Uniprot ID | F1LQR5 |
| Entrez ID | |
| Genbank protein ID | |
| Genbank nucleotide ID | |
| Ensembl protein ID | ENSRNOP00000063141 |
| Ensembl nucleotide ID | ENSRNOG00000008593 |
| Gene name | Receptor-like tyrosine kinase |
| Gene symbol | Ryk |
| Organism | Rattus norvegicus |
| NCBI taxa ID | 10116 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | |
| Sequence | MLPAAAPRSP SLAAARAGPS VSLYLSEDEV RRLLGLDAEL YYVRNDLISH YALSFNLLVP 60 SETNFLHFTW HAKSKVEYKL GFQVDNFVAM GMPQVNISAQ GEVPRTLSVF RVELSCTGKV 120 DSEVMILMQL NLTVNSSKNF TVLNFKRRKM CYKKLEEVKT SALDKNTSRT IYDPVHAAPT 180 TSTRVFYISV GVCCAVIFLV AIILAVLHLH SMKRIELDDS ISASSSSQGL SQPSTQTTQY 240 LRADTPNNAT PVTSSSGYPT LRIEKNDLRS VTLLEAKAKV KDIAISRERV TLKDVLQEGT 300 FGRIFHGILV DEKDPNKEKQ TFVKTVKDQA SEVQVTMMLT ESCKLRGLHH RNLLPITHVC 360 IEEGEKPMVI SPYMNWGNLK LFLRQCKLVE ANNPQAISQQ DLVHMAIQIA CGMSYLARRE 420 VIHKDLAARN CVIDDTLQVK ITDNALSRDL FPMDYHCLGD NENRPVRWMA LESLVNNEFS 480 SASDVWAFGV TLWELMTLGQ TPYVDIDPFE MAAYLKDGYR IAQPINCPDE LFAVMACCWA 540 LDPEERPKFQ QLVQCLTEFH AALGAYV 567 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | RYK | 102170271 | A0A452FRV1 | Capra hircus | Prediction | More>> | ||
| 1:1 ortholog | RYK | 6259 | P34925 | CPO,CL/P | Homo sapiens | Publication | More>> | |
| 1:1 ortholog | Ryk | 20187 | Q01887 | CPO | E14.5 | Mus musculus | Publication | More>> |
| 1:1 ortholog | RYK | 470931 | H2QNE9 | Pan troglodytes | Prediction | More>> | ||
| 1:1 ortholog | Ryk | F1LQR5 | Rattus norvegicus | Prediction | More>> | |||
| 1:1 ortholog | ryk | 558502 | A2RRV7 | Danio rerio | Prediction | More>> |
| GO ID | GO Term |
|---|---|
| GO:0005737 | cytoplasm |
| GO:0005887 | integral component of plasma membrane |
| GO:0016020 | membrane |
| GO:0005634 | nucleus |
| GO:0005886 | plasma membrane |
| GO:0043235 | receptor complex |
| GO:0005524 | ATP binding |
| GO:0005109 | frizzled binding |
| GO:0004888 | transmembrane signaling receptor activity |
| GO:0042813 | Wnt-activated receptor activity |
| GO:0017147 | Wnt-protein binding |
| GO:0007411 | axon guidance |
| GO:0007409 | axonogenesis |
| GO:0036518 | chemorepulsion of dopaminergic neuron axon |
| GO:0071679 | commissural neuron axon guidance |
| GO:0022038 | corpus callosum development |
| GO:1904948 | midbrain dopaminergic neuron differentiation |
| GO:0007275 | multicellular organism development |
| GO:0050919 | negative chemotaxis |
| GO:0048843 | negative regulation of axon extension involved in axon guidance |
| GO:0007399 | nervous system development |
| GO:0030182 | neuron differentiation |
| GO:0031175 | neuron projection development |
| GO:0018108 | peptidyl-tyrosine phosphorylation |
| GO:1904938 | planar cell polarity pathway involved in axon guidance |
| GO:0033674 | positive regulation of kinase activity |
| GO:0043410 | positive regulation of MAPK cascade |
| GO:0048705 | skeletal system morphogenesis |
| GO:0007169 | transmembrane receptor protein tyrosine kinase signaling pathway |
| GO:0016055 | Wnt signaling pathway |