| Tag | Content |
|---|---|
| Uniprot ID | H2QNE9; A0A2J8QJ40; |
| Entrez ID | 470931 |
| Genbank protein ID | |
| Genbank nucleotide ID | XM_016941967.1; XM_016941970.1; XM_016941968.1; |
| Ensembl protein ID | ENSPTRP00000026572 |
| Ensembl nucleotide ID | ENSPTRG00000015419 |
| Gene name | Receptor like tyrosine kinase |
| Gene symbol | RYK |
| Organism | Pan troglodytes |
| NCBI taxa ID | 9598 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | |
| Sequence | MRGAARLGRP GRSCLPGARG LRAPPPPPLL LLLALLPLLP APGAAAAPAP RAPELQSASA 60 GPSVSLYLSE DEVRRLIGLD AELYYVRNDL ISHYALSFNL LVPSETNFLH FTWHAKSKVE 120 YKLGFQVDNV LAMDMPQVNI SVQGEVPRTL SVFRVELSCT GKVDSEVMIL MQLNLTVNSS 180 KNFTVLNFKR RKMCYKKLEE VKTSALDKNT SRTIYDPVHA APTTSTRVFY ISVGVCCAVI 240 FLVAIILAVL HLHSMKRIEL DDSISASSSS QGLSQPSTQT TQYLRADTPN NATPITSSLG 300 YPTLRIEKND LRSVTLLEAK AKVKDIAISR ERITLKDVLQ EGTFGRIFHG ILIDEKDPNK 360 EKQAFVKTVK DQASEIQVTM MLTESCKLRG LHHRNLLPIT HVCIEEGEKP MVILPYMNWG 420 NLKLFLRQCK LVEANNPQAI SQQDLVHMAI QIACGMSYLA RREVIHKDLA ARNCVIDDTL 480 QVKITDNALS RDLFPMDYHC LGDNENRPVR WMALESLVNN EFSSASDVWA FGVTLWELMT 540 LGQTPYVDID PFEMAAYLKD GYRIAQPINC PDELFAVMAC CWALDPEERP KFQQLVQCLT 600 EFHAALGAYV |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | RYK | 102170271 | A0A452FRV1 | Capra hircus | Prediction | More>> | ||
| 1:1 ortholog | RYK | 6259 | P34925 | CPO,CL/P | Homo sapiens | Publication | More>> | |
| 1:1 ortholog | Ryk | 20187 | Q01887 | CPO | E14.5 | Mus musculus | Publication | More>> |
| 1:1 ortholog | RYK | 470931 | H2QNE9 | Pan troglodytes | Prediction | More>> | ||
| 1:1 ortholog | Ryk | F1LQR5 | Rattus norvegicus | Prediction | More>> | |||
| 1:1 ortholog | ryk | 558502 | A2RRV7 | Danio rerio | Prediction | More>> |
| GO ID | GO Term |
|---|---|
| GO:0005737 | cytoplasm |
| GO:0005887 | integral component of plasma membrane |
| GO:0005634 | nucleus |
| GO:0043235 | receptor complex |
| GO:0005524 | ATP binding |
| GO:0005109 | frizzled binding |
| GO:0004672 | protein kinase activity |
| GO:0042813 | Wnt-activated receptor activity |
| GO:0017147 | Wnt-protein binding |
| GO:0007409 | axonogenesis |
| GO:0036518 | chemorepulsion of dopaminergic neuron axon |
| GO:0071679 | commissural neuron axon guidance |
| GO:0022038 | corpus callosum development |
| GO:1904948 | midbrain dopaminergic neuron differentiation |
| GO:0007275 | multicellular organism development |
| GO:0048843 | negative regulation of axon extension involved in axon guidance |
| GO:0007399 | nervous system development |
| GO:0018108 | peptidyl-tyrosine phosphorylation |
| GO:1904938 | planar cell polarity pathway involved in axon guidance |
| GO:0033674 | positive regulation of kinase activity |
| GO:0043410 | positive regulation of MAPK cascade |
| GO:0048705 | skeletal system morphogenesis |
| GO:0007169 | transmembrane receptor protein tyrosine kinase signaling pathway |
| Keyword ID | Keyword Term |
|---|---|
| KW-1185 | Reference proteome |