| Tag | Content |
|---|---|
| Uniprot ID | Q01887; Q61890; |
| Entrez ID | 20187 |
| Genbank protein ID | AAH06963.1; AAA40079.1; AAA40579.1; AAB25044.1; AAA67060.1; AAA02913.1; |
| Genbank nucleotide ID | NM_013649.3; NM_001042607.1; |
| Ensembl protein ID | ENSMUSP00000135858 |
| Ensembl nucleotide ID | ENSMUSG00000032547 |
| Gene name | Tyrosine-protein kinase RYK |
| Gene symbol | Ryk |
| Organism | Mus musculus |
| NCBI taxa ID | 10090 |
| Cleft type | CPO |
| Developmental stage | E14.5 |
| Data sources | Manually collected |
| Reference | 10932185 |
| Functional description | May be a coreceptor along with FZD8 of Wnt proteins, such as WNT1, WNT3, WNT3A and WNT5A. Involved in neuron differentiation, axon guidance, corpus callosum establishment and neurite outgrowth. In response to WNT3 stimulation, receptor C-terminal cleavage occurs in its transmembrane region and allows the C-terminal intracellular product to translocate from the cytoplasm to the nucleus where it plays a crucial role in neuronal development. |
| Sequence | MRAGRGGVPG SGGLRAPPPP LLLLLLAMLP AAAPRSPALA AAPAGPSVSL YLSEDEVRRL 60 LGLDAELYYV RNDLISHYAL SFNLLVPSET NFLHFTWHAK SKVEYKLGFQ VDNFVAMGMP 120 QVNISAQGEV PRTLSVFRVE LSCTGKVDSE VMILMQLNLT VNSSKNFTVL NFKRRKMCYK 180 KLEEVKTSAL DKNTSRTIYD PVHAAPTTST RVFYISVGVC CAVIFLVAII LAVLHLHSMK 240 RIELDDSISA SSSSQGLSQP STQTTQYLRA DTPNNATPIT SSSGYPTLRI EKNDLRSVTL 300 LEAKAKVKDI AISRERITLK DVLQEGTFGR IFHGILVDEK DPNKEKQTFV KTVKDQASEV 360 QVTMMLTESC KLRGLHHRNL LPITHVCIEE GEKPMVVLPY MNWGNLKLFL RQCKLVEANN 420 PQAISQQDLV HMAIQIACGM SYLARREVIH RDLAARNCVI DDTLQVKITD NALSRDLFPM 480 DYHCLGDNEN RPVRWMALES LVNNEFSSAS DVWAFGVTLW ELMTLGQTPY VDIDPFEMAA 540 YLKDGYRIAQ PINCPDELFA VMACCWALDP EERPKFQQLV QCLTEFHAAL GAYV 594 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | RYK | 102170271 | A0A452FRV1 | Capra hircus | Prediction | More>> | ||
| 1:1 ortholog | RYK | 6259 | P34925 | CPO,CL/P | Homo sapiens | Publication | More>> | |
| 1:1 ortholog | Ryk | 20187 | Q01887 | CPO | E14.5 | Mus musculus | Publication | More>> |
| 1:1 ortholog | RYK | 470931 | H2QNE9 | Pan troglodytes | Prediction | More>> | ||
| 1:1 ortholog | Ryk | F1LQR5 | Rattus norvegicus | Prediction | More>> | |||
| 1:1 ortholog | ryk | 558502 | A2RRV7 | Danio rerio | Prediction | More>> |
| Gene symbol | Significant Variants/SNPS | Methods | PubMed ID |
|---|---|---|---|
| RYK | c.1355G>A; p.Y452C | Direct sequencing; TDT | 16681403 |
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0004888 | transmembrane signaling receptor activity | ISO |
| GO:0005109 | frizzled binding | IPI |
| GO:0005515 | protein binding | IPI |
| GO:0005524 | ATP binding | IEA |
| GO:0017147 | Wnt-protein binding | IPI |
| GO:0017147 | Wnt-protein binding | TAS |
| GO:0042813 | Wnt-activated receptor activity | IPI |
| GO:0042813 | Wnt-activated receptor activity | TAS |
| GO:0004713 | protein tyrosine kinase activity | IDA |
| GO:0004714 | transmembrane receptor protein tyrosine kinase activity | IBA |
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0007169 | transmembrane receptor protein tyrosine kinase signaling pathway | IBA |
| GO:0007275 | multicellular organism development | IBA |
| GO:0007399 | nervous system development | IBA |
| GO:0007409 | axonogenesis | IGI |
| GO:0007409 | axonogenesis | IBA |
| GO:0007411 | axon guidance | IDA |
| GO:0007411 | axon guidance | IMP |
| GO:0007411 | axon guidance | TAS |
| GO:0016055 | Wnt signaling pathway | IDA |
| GO:0016055 | Wnt signaling pathway | IGI |
| GO:0018108 | peptidyl-tyrosine phosphorylation | IEA |
| GO:0022038 | corpus callosum development | IMP |
| GO:0030182 | neuron differentiation | IDA |
| GO:0031175 | neuron projection development | IMP |
| GO:0033674 | positive regulation of kinase activity | IBA |
| GO:0036518 | chemorepulsion of dopaminergic neuron axon | IGI |
| GO:0043410 | positive regulation of MAPK cascade | ISS |
| GO:0043410 | positive regulation of MAPK cascade | ISO |
| GO:0048705 | skeletal system morphogenesis | IMP |
| GO:0048843 | negative regulation of axon extension involved in axon guidance | IGI |
| GO:0050919 | negative chemotaxis | IGI |
| GO:0061643 | chemorepulsion of axon | TAS |
| GO:0071679 | commissural neuron axon guidance | IMP |
| GO:1904938 | planar cell polarity pathway involved in axon guidance | IGI |
| GO:1904948 | midbrain dopaminergic neuron differentiation | IMP |
| GO:1904953 | Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation | ISS |
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0005634 | nucleus | IDA |
| GO:0005737 | cytoplasm | IDA |
| GO:0005886 | plasma membrane | IDA |
| GO:0005887 | integral component of plasma membrane | IBA |
| GO:0016020 | membrane | IDA |
| GO:0043235 | receptor complex | IBA |
| Reactome ID | Reactome Term | Evidence |
|---|---|---|
| R-MMU-162582 | Signal Transduction | IEA |
| R-MMU-195721 | Signaling by WNT | IEA |
| R-MMU-201681 | TCF dependent signaling in response to WNT | IEA |
| Keyword ID | Keyword Term |
|---|---|
| KW-0067 | ATP-binding |
| KW-0963 | Cytoplasm |
| KW-0325 | Glycoprotein |
| KW-0418 | Kinase |
| KW-0472 | Membrane |
| KW-0547 | Nucleotide-binding |
| KW-0539 | Nucleus |
| KW-0597 | Phosphoprotein |
| KW-0675 | Receptor |
| KW-1185 | Reference proteome |
| KW-0732 | Signal |
| KW-0808 | Transferase |
| KW-0812 | Transmembrane |
| KW-1133 | Transmembrane helix |
| KW-0829 | Tyrosine-protein kinase |
| KW-0879 | Wnt signaling pathway |