| Tag | Content |
|---|---|
| Uniprot ID | A7MB15 |
| Entrez ID | 445417 |
| Genbank protein ID | AAI51284.1 |
| Genbank nucleotide ID | NM_001101048.1 |
| Ensembl protein ID | ENSBTAP00000002720 |
| Ensembl nucleotide ID | ENSBTAG00000002107 |
| Gene name | FZD1 protein |
| Gene symbol | FZD1 |
| Organism | Bos taurus |
| NCBI taxa ID | 9913 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | |
| Sequence | MAEEEAPKKS RAAGGGGGGG SWELCAGALR TVPAAEGSGD AGSRRRPPAD SRRLARRLLL 60 LLWLLEAPLL LGVRAQAAGQ GPGPGQQPPP PQQQQSGQQY NGERGISIPD HGYCQPISIP 120 LCTDIAYNQT IMPNLLGHTN QEDAGLEVHQ FYPLVKVQCS AELKFFLCSM YAPVCTVLEQ 180 ALPPCRSLCE RARQGCEALM NKFGFQWPDT LKCEKFPVHG AGELCVGQNT SDKGTPTPSL 240 LPEFWTSNPQ HGGGGHRGGG FAGGAGASER GKFSCPRALK VPSYLNYHFL GEKDCGAPCE 300 PTKVYGLMYF GPEELRFSRT WIGIWSVLCC ASTLFTVLTY LVDMRRFSYP ERPIIFLSGC 360 YTAVAVAYIA GFLLEDRVVC NDKFAEDGAR TVAQGTKKEG CTILFMMLYF FSMASSIWWV 420 ILSLTWFLAA GMKWGHEAIE ANSQYFHLAA WAVPAIKTIT ILALGQVDGD VLSGVCFVGL 480 NNVDALRGFV LAPLFVYLFI GTSFLLAGFV SLFRIRTIMK HDGTKTEKLE KLMVRIGVFS 540 VLYTVPATIV IACYFYEQAF RDQWERSWVA QSCKSYAIPC PHLQAGGAPP HPPMSPDFTV 600 FMIKYLMTLI VGITSGFWIW SGKTLNSWRK FYTRLTNSKQ GETTV 645 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | FZD1 | 445417 | A7MB15 | Bos taurus | Prediction | More>> | ||
| 1:1 ortholog | FZD1 | 482294 | F1PCN5 | Canis lupus familiaris | Prediction | More>> | ||
| 1:1 ortholog | FZD1 | A0A452EC64 | Capra hircus | Prediction | More>> | |||
| 1:1 ortholog | FZD1 | 8321 | Q9UP38 | Homo sapiens | Prediction | More>> | ||
| 1:1 ortholog | Fzd1 | 14362 | O70421 | CPO | Mus musculus | Publication | More>> | |
| 1:1 ortholog | Fzd1 | 58868 | G3V833 | Rattus norvegicus | Prediction | More>> |
| GO ID | GO Term |
|---|---|
| GO:0009986 | cell surface |
| GO:0016021 | integral component of membrane |
| GO:0005886 | plasma membrane |
| GO:0005109 | frizzled binding |
| GO:0030165 | PDZ domain binding |
| GO:0042813 | Wnt-activated receptor activity |
| GO:0017147 | Wnt-protein binding |
| GO:0036520 | astrocyte-dopaminergic neuron signaling |
| GO:0035425 | autocrine signaling |
| GO:0060070 | canonical Wnt signaling pathway |
| GO:0044338 | canonical Wnt signaling pathway involved in mesenchymal stem cell differentiation |
| GO:0044339 | canonical Wnt signaling pathway involved in osteoblast differentiation |
| GO:0030855 | epithelial cell differentiation |
| GO:0060022 | hard palate development |
| GO:0003149 | membranous septum morphogenesis |
| GO:0003150 | muscular septum morphogenesis |
| GO:0030514 | negative regulation of BMP signaling pathway |
| GO:0090090 | negative regulation of canonical Wnt signaling pathway |
| GO:1903204 | negative regulation of oxidative stress-induced neuron death |
| GO:0045892 | negative regulation of transcription, DNA-templated |
| GO:0003151 | outflow tract morphogenesis |
| GO:0090179 | planar cell polarity pathway involved in neural tube closure |
| GO:0051091 | positive regulation of DNA-binding transcription factor activity |
| GO:0001934 | positive regulation of protein phosphorylation |
| GO:0045893 | positive regulation of transcription, DNA-templated |
| GO:1905606 | regulation of presynapse assembly |
| GO:0042493 | response to drug |