| Tag | Content |
|---|---|
| Uniprot ID | F1PCN5 |
| Entrez ID | 482294 |
| Genbank protein ID | |
| Genbank nucleotide ID | XM_539411.6 |
| Ensembl protein ID | ENSCAFP00000002804 |
| Ensembl nucleotide ID | ENSCAFG00000001906 |
| Gene name | Frizzled class receptor 1 |
| Gene symbol | FZD1 |
| Organism | Canis lupus familiaris |
| NCBI taxa ID | 9615 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | |
| Sequence | MAEEEAPKKS RAAGGRASWE LCAGALPAGP GAEPSGDAGS RRRRRPRADS GRLARRLLLL 60 LWLLEAPLLP GVRGQAGGQG PGQGPGPGQQ PPPPAPQQQQ SGQQYNGERG ISIPDHGYCQ 120 PISIPLCTDI AYNQTIMPNL LGHTNQEDAG LEVHQFYPLV KVQCSAELKF FLCSMYAPVC 180 TVLEQALPPC RSLCERARQG CEALMNKFGF QWPDTLKCEK FPVHGAGELC VGQNTSDKGT 240 PTPSLLPEFW TSNPQHGGGG HRGGGFPGGA GASERGKFSC PRALKVPSYL NYHFLGEKDC 300 GAPCEPTKVY GLMYFGPEEL RFSRTWIGIW SVLCCASTLF TVLTYLVDMR RFSYPERPII 360 FLSGCYTAVA VAYIAGFLLE DRVVCNDKFS EDGARTVAQG TKKEGCTILF MMLYFFSMAS 420 SIWWVILSLT WFLAAGMKWG HEAIEANSQY FHLAAWAVPA IKTITILALG QVDGDVLSGV 480 CFVGLNNVDA LRGFVLAPLF VYLFIGTSFL LAGFVSLFRI RTIMKHDGTK TEKLEKLMVR 540 IGVFSVLYTV PATIVIACYF YEQAFRDQWE RSWVAQSCKS YAIPCPHLQA GGGAPPHPPM 600 SPDFTVFMIK YLMTLIVGIT SGFWIWSGKT LNSWRKFYTR LTNSKQGETT V 651 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | FZD1 | 445417 | A7MB15 | Bos taurus | Prediction | More>> | ||
| 1:1 ortholog | FZD1 | 482294 | F1PCN5 | Canis lupus familiaris | Prediction | More>> | ||
| 1:1 ortholog | FZD1 | A0A452EC64 | Capra hircus | Prediction | More>> | |||
| 1:1 ortholog | FZD1 | 8321 | Q9UP38 | Homo sapiens | Prediction | More>> | ||
| 1:1 ortholog | Fzd1 | 14362 | O70421 | CPO | Mus musculus | Publication | More>> | |
| 1:1 ortholog | Fzd1 | 58868 | G3V833 | Rattus norvegicus | Prediction | More>> |
| GO ID | GO Term |
|---|---|
| GO:0009986 | cell surface |
| GO:0016021 | integral component of membrane |
| GO:0005886 | plasma membrane |
| GO:0005109 | frizzled binding |
| GO:0030165 | PDZ domain binding |
| GO:0042813 | Wnt-activated receptor activity |
| GO:0017147 | Wnt-protein binding |
| GO:0036520 | astrocyte-dopaminergic neuron signaling |
| GO:0035425 | autocrine signaling |
| GO:0060070 | canonical Wnt signaling pathway |
| GO:0044338 | canonical Wnt signaling pathway involved in mesenchymal stem cell differentiation |
| GO:0044339 | canonical Wnt signaling pathway involved in osteoblast differentiation |
| GO:0030855 | epithelial cell differentiation |
| GO:0060022 | hard palate development |
| GO:0003149 | membranous septum morphogenesis |
| GO:0003150 | muscular septum morphogenesis |
| GO:0030514 | negative regulation of BMP signaling pathway |
| GO:0090090 | negative regulation of canonical Wnt signaling pathway |
| GO:1903204 | negative regulation of oxidative stress-induced neuron death |
| GO:0045892 | negative regulation of transcription, DNA-templated |
| GO:0003151 | outflow tract morphogenesis |
| GO:0090179 | planar cell polarity pathway involved in neural tube closure |
| GO:0051091 | positive regulation of DNA-binding transcription factor activity |
| GO:0001934 | positive regulation of protein phosphorylation |
| GO:0045893 | positive regulation of transcription, DNA-templated |
| GO:1905606 | regulation of presynapse assembly |
| GO:0042493 | response to drug |