| Tag | Content |
|---|---|
| Uniprot ID | O70421; O08974; Q7TS82; |
| Entrez ID | 14362 |
| Genbank protein ID | AAC12873.2; AAH53010.1; EDL14633.1; AAC01952.1; BAE25269.1; |
| Genbank nucleotide ID | NM_021457.3 |
| Ensembl protein ID | ENSMUSP00000058629 |
| Ensembl nucleotide ID | ENSMUSG00000044674 |
| Gene name | Frizzled-1 |
| Gene symbol | Fzd1 |
| Organism | Mus musculus |
| NCBI taxa ID | 10090 |
| Cleft type | CPO |
| Developmental stage | |
| Data sources | Manually collected |
| Reference | 20940229 |
| Functional description | Receptor for Wnt proteins (PubMed:15923619). Activated by WNT7B (PubMed:15923619). Activated by WNT3A, WNT3, WNT1 and to a lesser extent WNT2, but apparently not by WNT4, WNT5A, WNT5B, WNT6, WNT7A or WNT7B (By similarity). Contradictory results showing activation by WNT7B have been described for mouse (PubMed:15923619). Functions in the canonical Wnt/beta-catenin signaling pathway (PubMed:15923619). The canonical Wnt/beta-catenin signaling pathway leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes (PubMed:15923619). A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues (Probable). |
| Sequence | MAEEAAPSES RAAGRLSLEL CAEALPGRRE EVGHEDTASH RRPRADPRRW ASGLLLLLWL 60 LEAPLLLGVR AQAAGQVSGP GQQAPPPPQP QQSGQQYNGE RGISIPDHGY CQPISIPLCT 120 DIAYNQTIMP NLLGHTNQED AGLEVHQFYP LVKVQCSAEL KFFLCSMYAP VCTVLEQALP 180 PCRSLCERAR QGCEALMNKF GFQWPDTLKC EKFPVHGAGE LCVGQNTSDK GTPTPSLLPE 240 FWTSNPQHGG GGYRGGYPGG AGTVERGKFS CPRALRVPSY LNYHFLGEKD CGAPCEPTKV 300 YGLMYFGPEE LRFSRTWIGI WSVLCCASTL FTVLTYLVDM RRFSYPERPI IFLSGCYTAV 360 AVAYIAGFLL EDRVVCNDKF AEDGARTVAQ GTKKEGCTIL FMMLYFFSMA SSIWWVILSL 420 TWFLAAGMKW GHEAIEANSQ YFHLAAWAVP AIKTITILAL GQVDGDVLSG VCFVGLNNVD 480 ALRGFVLAPL FVYLFIGTSF LLAGFVSLFR IRTIMKHDGT KTEKLEKLMV RIGVFSVLYT 540 VPATIVIACY FYEQAFRDQW ERSWVAQSCK SYAIPCPHLQ GGGGVPPHPP MSPDFTVFMI 600 KYLMTLIVGI TSGFWIWSGK TLNSWRKFYT RLTNSKQGET TV 642 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | FZD1 | 445417 | A7MB15 | Bos taurus | Prediction | More>> | ||
| 1:1 ortholog | FZD1 | 482294 | F1PCN5 | Canis lupus familiaris | Prediction | More>> | ||
| 1:1 ortholog | FZD1 | A0A452EC64 | Capra hircus | Prediction | More>> | |||
| 1:1 ortholog | FZD1 | 8321 | Q9UP38 | Homo sapiens | Prediction | More>> | ||
| 1:1 ortholog | Fzd1 | 14362 | O70421 | CPO | Mus musculus | Publication | More>> | |
| 1:1 ortholog | Fzd1 | 58868 | G3V833 | Rattus norvegicus | Prediction | More>> |
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0004930 | G protein-coupled receptor activity | IEA |
| GO:0005102 | signaling receptor binding | ISO |
| GO:0005109 | frizzled binding | ISO |
| GO:0017147 | Wnt-protein binding | ISO |
| GO:0017147 | Wnt-protein binding | IPI |
| GO:0017147 | Wnt-protein binding | IBA |
| GO:0030165 | PDZ domain binding | ISO |
| GO:0042802 | identical protein binding | ISO |
| GO:0042803 | protein homodimerization activity | ISO |
| GO:0042813 | Wnt-activated receptor activity | ISS |
| GO:0042813 | Wnt-activated receptor activity | ISO |
| GO:0042813 | Wnt-activated receptor activity | IBA |
| GO:0046982 | protein heterodimerization activity | ISO |
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0001934 | positive regulation of protein phosphorylation | IMP |
| GO:0003149 | membranous septum morphogenesis | IGI |
| GO:0003150 | muscular septum morphogenesis | IGI |
| GO:0003151 | outflow tract morphogenesis | IGI |
| GO:0007186 | G protein-coupled receptor signaling pathway | IEA |
| GO:0007267 | cell-cell signaling | ISO |
| GO:0007267 | cell-cell signaling | IDA |
| GO:0010976 | positive regulation of neuron projection development | ISO |
| GO:0016055 | Wnt signaling pathway | ISO |
| GO:0030514 | negative regulation of BMP signaling pathway | IDA |
| GO:0030855 | epithelial cell differentiation | IDA |
| GO:0030855 | epithelial cell differentiation | IGI |
| GO:0035425 | autocrine signaling | ISO |
| GO:0036520 | astrocyte-dopaminergic neuron signaling | IMP |
| GO:0042493 | response to drug | ISO |
| GO:0044338 | canonical Wnt signaling pathway involved in mesenchymal stem cell differentiation | ISO |
| GO:0044339 | canonical Wnt signaling pathway involved in osteoblast differentiation | ISO |
| GO:0045892 | negative regulation of transcription, DNA-templated | IMP |
| GO:0045893 | positive regulation of transcription, DNA-templated | ISO |
| GO:0051091 | positive regulation of DNA-binding transcription factor activity | ISO |
| GO:0060022 | hard palate development | IGI |
| GO:0060070 | canonical Wnt signaling pathway | ISO |
| GO:0060070 | canonical Wnt signaling pathway | IMP |
| GO:0060070 | canonical Wnt signaling pathway | IGI |
| GO:0060070 | canonical Wnt signaling pathway | IBA |
| GO:0060412 | ventricular septum morphogenesis | IGI |
| GO:0090090 | negative regulation of canonical Wnt signaling pathway | IDA |
| GO:0090179 | planar cell polarity pathway involved in neural tube closure | IGI |
| GO:1903204 | negative regulation of oxidative stress-induced neuron death | IMP |
| GO:1905606 | regulation of presynapse assembly | IDA |
| GO:1905606 | regulation of presynapse assembly | IMP |
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0005886 | plasma membrane | ISO |
| GO:0005886 | plasma membrane | IBA |
| GO:0009986 | cell surface | ISO |
| GO:0016021 | integral component of membrane | IBA |
| GO:0043005 | neuron projection | ISO |
| Reactome ID | Reactome Term | Evidence |
|---|---|---|
| R-MMU-162582 | Signal Transduction | IEA |
| R-MMU-195721 | Signaling by WNT | IEA |
| R-MMU-201681 | TCF dependent signaling in response to WNT | IEA |
| R-MMU-3858494 | Beta-catenin independent WNT signaling | IEA |
| R-MMU-4086400 | PCP/CE pathway | IEA |
| R-MMU-4608870 | Asymmetric localization of PCP proteins | IEA |
| R-MMU-4641262 | Disassembly of the destruction complex and recruitment of AXIN to the membrane | IEA |
| Keyword ID | Keyword Term |
|---|---|
| KW-1003 | Cell membrane |
| KW-0217 | Developmental protein |
| KW-1015 | Disulfide bond |
| KW-0297 | G-protein coupled receptor |
| KW-0325 | Glycoprotein |
| KW-0472 | Membrane |
| KW-0675 | Receptor |
| KW-1185 | Reference proteome |
| KW-0732 | Signal |
| KW-0807 | Transducer |
| KW-0812 | Transmembrane |
| KW-1133 | Transmembrane helix |
| KW-0832 | Ubl conjugation |
| KW-0879 | Wnt signaling pathway |