| Tag | Content |
|---|---|
| Uniprot ID | G3V833 |
| Entrez ID | 58868 |
| Genbank protein ID | EDL84350.1 |
| Genbank nucleotide ID | NM_021266.3 |
| Ensembl protein ID | ENSRNOP00000021979 |
| Ensembl nucleotide ID | ENSRNOG00000016242 |
| Gene name | Frizzled homolog 1 (Drosophila) |
| Gene symbol | Fzd1 |
| Organism | Rattus norvegicus |
| NCBI taxa ID | 10116 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | |
| Sequence | MAEEAVPSES RAAGRPSLEL CAVALPGRRE EVGHQDTAGH RRPRADSRCW ARGLLLLLWL 60 LEAPLLLGVR AQAAGQVSGP GQQAPPPPQP QQGGQQYNGE RGISIPDHGY CQPISIPLCT 120 DIAYNQTIMP NLLGHTNQED AGLEVHQFYP LVKVQCSAEL KFFLCSMYAP VCTVLEQALP 180 PCRSLCERAR QGCEALMNKF GFQWPDTLKC EKFPVHGAGE LCVGQNTSDK GTPTPSLLPE 240 FWTSNPQHGG GGYRGGYPGG AGPVERGKFS CPRALRVPSY LNYHFLGEKD CGAPCEPTKV 300 YGLMYFGPEE LRFSRTWIGI WSVLCCASTL FTVLTYLVDM RRFSYPERPI IFLSGCYTAV 360 AVAYIAGFLL EDRVVCNDKF AEDGARTVAQ GTKKEGCTIL FMMLYFFSMA SSIWWVILSL 420 TWFLAAGMKW GHEAIEANSQ YFHLAAWAVP AIKTITILAL GQVDGDVLSG VCFVGLNNVD 480 ALRGFVLAPL FVYLFIGTSF LLAGFVSLFR IRTIMKHDGT KTEKLEKLMV RIGVFSVLYT 540 VPATIVIACY FYEQAFRDQW ERSWVAQSCK SYAIPCPHLQ GGGGVPPHPP MSPDFTVFMI 600 KYLMTLIVGI TSGFWIWSGK TLNSWRKFYT RLTNSKQGET TV 642 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | FZD1 | 445417 | A7MB15 | Bos taurus | Prediction | More>> | ||
| 1:1 ortholog | FZD1 | 482294 | F1PCN5 | Canis lupus familiaris | Prediction | More>> | ||
| 1:1 ortholog | FZD1 | A0A452EC64 | Capra hircus | Prediction | More>> | |||
| 1:1 ortholog | FZD1 | 8321 | Q9UP38 | Homo sapiens | Prediction | More>> | ||
| 1:1 ortholog | Fzd1 | 14362 | O70421 | CPO | Mus musculus | Publication | More>> | |
| 1:1 ortholog | Fzd1 | 58868 | G3V833 | Rattus norvegicus | Prediction | More>> |
| GO ID | GO Term |
|---|---|
| GO:0009986 | cell surface |
| GO:0016021 | integral component of membrane |
| GO:0005109 | frizzled binding |
| GO:0030165 | PDZ domain binding |
| GO:0042813 | Wnt-activated receptor activity |
| GO:0017147 | Wnt-protein binding |
| GO:0036520 | astrocyte-dopaminergic neuron signaling |
| GO:0035425 | autocrine signaling |
| GO:0044338 | canonical Wnt signaling pathway involved in mesenchymal stem cell differentiation |
| GO:0044339 | canonical Wnt signaling pathway involved in osteoblast differentiation |
| GO:0030855 | epithelial cell differentiation |
| GO:0060022 | hard palate development |
| GO:0003149 | membranous septum morphogenesis |
| GO:0003150 | muscular septum morphogenesis |
| GO:0030514 | negative regulation of BMP signaling pathway |
| GO:0090090 | negative regulation of canonical Wnt signaling pathway |
| GO:1903204 | negative regulation of oxidative stress-induced neuron death |
| GO:0045892 | negative regulation of transcription, DNA-templated |
| GO:0003151 | outflow tract morphogenesis |
| GO:0090179 | planar cell polarity pathway involved in neural tube closure |
| GO:0051091 | positive regulation of DNA-binding transcription factor activity |
| GO:0001934 | positive regulation of protein phosphorylation |
| GO:0045893 | positive regulation of transcription, DNA-templated |
| GO:1905606 | regulation of presynapse assembly |
| GO:0042493 | response to drug |