Gene: sostdc1a

Basic information

Tag Content
Uniprot ID A7MCD1
Entrez ID 550261
Genbank protein ID AAI52133.1
Genbank nucleotide ID NM_001017598.2
Ensembl protein ID ENSDARP00000090566
Ensembl nucleotide ID ENSDARG00000068892
Gene name Sclerostin domain-containing 1a
Gene symbol sostdc1a
Organism Danio rerio
NCBI taxa ID 7955
Cleft type
Developmental stage
Data sources Homology search
Reference
Functional description
Sequence
MYINAPESCN FMVLFCFLIR SGLTLKNDAT EIFYSHVVSP VQDAQSNASL NRARSGGRGF 60
STHDRERIPV GCRELRSTKY ISDGQCTSIN PVKELVCTGQ CLPAQMLPNW IGGYGKKSWN 120
RRNSQEWRCV NDKTRTQRIQ LQCQDGSTRT YKITVVTSCK CKRYSRQHNE SGVKSEGYSH 180
SQIKKQKSKV ATRTES 196

Abbreviation :
CLO : cleft lip only. CPO : cleft palate only. CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.

Protein disorder information

Orthologous information

Relation Gene symbol Entrez ID UniProt ID Cleft type Developmental stage Species Evidence Details
1:1 orthologSOSTDC1523184Q2HJ20Bos taurusPredictionMore>>
1:1 orthologSOSTDC1102178138A0A452EBH8Capra hircusPredictionMore>>
1:1 orthologSOSTDC1100052877F6T7A1Equus caballusPredictionMore>>
1:1 orthologSOSTDC125928Q6X4U4Homo sapiensPredictionMore>>
1:1 orthologSostdc166042Q9CQN4CPOMus musculusPublicationMore>>
1:1 orthologSOSTDC1100736999F1SEJ1Sus scrofaPredictionMore>>
1:1 orthologSOSTDC1100354321G1T3J2Oryctolagus cuniculusPredictionMore>>
1:1 orthologSostdc1266803Q642G2Rattus norvegicusPredictionMore>>
1:1 orthologsostdc1a550261A7MCD1Danio rerioPredictionMore>>

Gene ontology

GO ID GO Term
GO:0005615 extracellular space
GO:0036122 BMP binding
GO:0030514 negative regulation of BMP signaling pathway
GO:0030178 negative regulation of Wnt signaling pathway
GO:0016055 Wnt signaling pathway

Functional annotations

Keywords

Keyword ID Keyword Term
KW-1015 Disulfide bond
KW-1185 Reference proteome
KW-0964 Secreted
KW-0732 Signal
KW-0879 Wnt signaling pathway

Interpro

InterPro ID InterPro Term
IPR006207 Cys_knot_C
IPR029034 Cystine-knot_cytokine
IPR008835 Sclerostin/SOSTDC1

PROSITE

PROSITE ID PROSITE Term
PS01225 CTCK_2

Pfam

Pfam ID Pfam Term
PF05463 Sclerostin