| Tag | Content |
|---|---|
| Uniprot ID | Q642G2; Q8CJA4; |
| Entrez ID | 266803 |
| Genbank protein ID | AAN45848.1; AAH81710.1; |
| Genbank nucleotide ID | NM_153737.1 |
| Ensembl protein ID | ENSRNOP00000008106 |
| Ensembl nucleotide ID | ENSRNOG00000005770 |
| Gene name | Sclerostin domain-containing protein 1 |
| Gene symbol | Sostdc1 |
| Organism | Rattus norvegicus |
| NCBI taxa ID | 10116 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | Directly antagonizes activity of BMP2, BMP4, BMP6 and BMP7 in a dose-dependent manner (By similarity). May be involved in the onset of endometrial receptivity for implantation/sensitization for the decidual cell reaction. Enhances Wnt signaling and inhibits TGF-beta signaling. |
| Sequence | MLPPAIHLSL IPLLCILMKN CLAFKNDATE ILYSHVVKPV SAHPSSNSTL NQARNGGRHF 60 SSTGLDRNSR VQVGCRELRS TKYISDGQCT SISPLKELVC AGECLPLPVL PNWIGGGYGT 120 KYWSRRSSQE WRCVNDKTRT QRIQLQCQDG STRTYKITVV TACKCKRYTR QHNESSHNFE 180 SVSPAKPAQH HRERKRASKS SKHSLS 206 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | SOSTDC1 | 523184 | Q2HJ20 | Bos taurus | Prediction | More>> | ||
| 1:1 ortholog | SOSTDC1 | 102178138 | A0A452EBH8 | Capra hircus | Prediction | More>> | ||
| 1:1 ortholog | SOSTDC1 | 100052877 | F6T7A1 | Equus caballus | Prediction | More>> | ||
| 1:1 ortholog | SOSTDC1 | 25928 | Q6X4U4 | Homo sapiens | Prediction | More>> | ||
| 1:1 ortholog | Sostdc1 | 66042 | Q9CQN4 | CPO | Mus musculus | Publication | More>> | |
| 1:1 ortholog | SOSTDC1 | 100736999 | F1SEJ1 | Sus scrofa | Prediction | More>> | ||
| 1:1 ortholog | SOSTDC1 | 100354321 | G1T3J2 | Oryctolagus cuniculus | Prediction | More>> | ||
| 1:1 ortholog | Sostdc1 | 266803 | Q642G2 | Rattus norvegicus | Prediction | More>> | ||
| 1:1 ortholog | sostdc1a | 550261 | A7MCD1 | Danio rerio | Prediction | More>> |
| GO ID | GO Term |
|---|---|
| GO:0005615 | extracellular space |
| GO:0036122 | BMP binding |
| GO:0098821 | BMP receptor activity |
| GO:0007566 | embryo implantation |
| GO:0031069 | hair follicle morphogenesis |
| GO:0060648 | mammary gland bud morphogenesis |
| GO:0030514 | negative regulation of BMP signaling pathway |
| GO:0090090 | negative regulation of canonical Wnt signaling pathway |
| GO:0010454 | negative regulation of cell fate commitment |
| GO:2000016 | negative regulation of determination of dorsal identity |
| GO:0045662 | negative regulation of myoblast differentiation |
| GO:0030178 | negative regulation of Wnt signaling pathway |
| GO:0042475 | odontogenesis of dentin-containing tooth |
| GO:0007389 | pattern specification process |
| GO:0016055 | Wnt signaling pathway |
| PROSITE ID | PROSITE Term |
|---|---|
| PS01225 | CTCK_2 |
| Pfam ID | Pfam Term |
|---|---|
| PF05463 | Sclerostin |