Gene: Sostdc1

Basic information

Tag Content
Uniprot ID Q9CQN4; Q8CF09;
Entrez ID 66042
Genbank protein ID BAB25378.1; AAH21458.1; AAQ83297.1; BAB25333.1; BAC20332.1; BAB22068.1; BAC25193.1; AAN08617.1; BAB21957.1;
Genbank nucleotide ID NM_025312.3
Ensembl protein ID ENSMUSP00000040230
Ensembl nucleotide ID ENSMUSG00000036169
Gene name Sclerostin domain-containing protein 1
Gene symbol Sostdc1
Organism Mus musculus
NCBI taxa ID 10090
Cleft type CPO
Developmental stage
Data sources Manually collected
Reference 30235284; 28692808;
Functional description May be involved in the onset of endometrial receptivity for implantation/sensitization for the decidual cell reaction. Enhances Wnt signaling and inhibits TGF-beta signaling (By similarity). Directly antagonizes activity of BMP2, BMP4, BMP6 and BMP7 in a dose-dependent manner.
Sequence
MLPPAIHLSL IPLLCILMRN CLAFKNDATE ILYSHVVKPV PAHPSSNSTL NQARNGGRHF 60
SSTGLDRNSR VQVGCRELRS TKYISDGQCT SISPLKELVC AGECLPLPVL PNWIGGGYGT 120
KYWSRRSSQE WRCVNDKTRT QRIQLQCQDG STRTYKITVV TACKCKRYTR QHNESSHNFE 180
SVSPAKPAQH HRERKRASKS SKHSLS 206

Abbreviation :
CLO : cleft lip only. CPO : cleft palate only. CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.

Protein structural annotations

3D structure in PDB database

There is no related protein structure for this gene.

Protein disorder information

Orthologous information

Relation Gene symbol Entrez ID UniProt ID Cleft type Developmental stage Species Evidence Details
1:1 orthologSOSTDC1523184Q2HJ20Bos taurusPredictionMore>>
1:1 orthologSOSTDC1102178138A0A452EBH8Capra hircusPredictionMore>>
1:1 orthologSOSTDC1100052877F6T7A1Equus caballusPredictionMore>>
1:1 orthologSOSTDC125928Q6X4U4Homo sapiensPredictionMore>>
1:1 orthologSostdc166042Q9CQN4CPOMus musculusPublicationMore>>
1:1 orthologSOSTDC1100736999F1SEJ1Sus scrofaPredictionMore>>
1:1 orthologSOSTDC1100354321G1T3J2Oryctolagus cuniculusPredictionMore>>
1:1 orthologSostdc1266803Q642G2Rattus norvegicusPredictionMore>>
1:1 orthologsostdc1a550261A7MCD1Danio rerioPredictionMore>>

Other genetic variants/mutations

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Gene Ontology (GO)/biological pathways

GO:Molecular Function

GO ID GO Term Evidence
GO:0005515 protein bindingIPI
GO:0036122 BMP bindingISO
GO:0098821 BMP receptor activityISO

GO:Biological Process

GO ID GO Term Evidence
GO:0007389 pattern specification processIMP
GO:0010454 negative regulation of cell fate commitmentIMP
GO:0016055 Wnt signaling pathwayIEA
GO:0030178 negative regulation of Wnt signaling pathwayISO
GO:0030509 BMP signaling pathwayIEA
GO:0030514 negative regulation of BMP signaling pathwayISO
GO:0030514 negative regulation of BMP signaling pathwayIDA
GO:0030514 negative regulation of BMP signaling pathwayIGI
GO:0031069 hair follicle morphogenesisIMP
GO:0042475 odontogenesis of dentin-containing toothIGI
GO:0042475 odontogenesis of dentin-containing toothIMP
GO:0045662 negative regulation of myoblast differentiationISO
GO:0060648 mammary gland bud morphogenesisIMP
GO:0090090 negative regulation of canonical Wnt signaling pathwayIMP
GO:2000016 negative regulation of determination of dorsal identityISO

GO:Cellular Component

GO ID GO Term Evidence
GO:0005615 extracellular spaceISO
GO:0005615 extracellular spaceIDA

Reactome Pathway

Reactome ID Reactome Term Evidence

Functional annotations

Keywords

Keyword ID Keyword Term
KW-1015 Disulfide bond
KW-0325 Glycoprotein
KW-1185 Reference proteome
KW-0964 Secreted
KW-0732 Signal
KW-0879 Wnt signaling pathway

Interpro

InterPro ID InterPro Term
IPR006207 Cys_knot_C
IPR029034 Cystine-knot_cytokine
IPR008835 Sclerostin/SOSTDC1

PROSITE

PROSITE ID PROSITE Term
PS01225 CTCK_2

Pfam

Pfam ID Pfam Term
PF05463 Sclerostin