Gene: SOSTDC1

Basic information

Tag Content
Uniprot ID F6T7A1
Entrez ID 100052877
Genbank protein ID
Genbank nucleotide ID XM_001495777.5
Ensembl protein ID ENSECAP00000009939
Ensembl nucleotide ID ENSECAG00000012109
Gene name Sclerostin domain containing 1
Gene symbol SOSTDC1
Organism Equus caballus
NCBI taxa ID 9796
Cleft type
Developmental stage
Data sources Homology search
Reference
Functional description
Sequence
MLPPAIHFYL IPLACILMKS CLAFKNDATE ILYSHVVKPV PAHSSSNNTM NQARNGGRHF 60
SNTGLDRNTR VQVGCRELRS TKYISDGQCT SISPLKELVC AGECLPLPVL PNWIGGGYGT 120
KYWSRRSSQE WRCVNDKTRT QRIQLQCQDG STRTYKITVV TACKCKRYTR QHNESSHNFE 180
SMSPAKPAQH HRQRKRASKS SKHSMS 206

Abbreviation :
CLO : cleft lip only. CPO : cleft palate only. CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.

Protein disorder information

Orthologous information

Relation Gene symbol Entrez ID UniProt ID Cleft type Developmental stage Species Evidence Details
1:1 orthologSOSTDC1523184Q2HJ20Bos taurusPredictionMore>>
1:1 orthologSOSTDC1102178138A0A452EBH8Capra hircusPredictionMore>>
1:1 orthologSOSTDC1100052877F6T7A1Equus caballusPredictionMore>>
1:1 orthologSOSTDC125928Q6X4U4Homo sapiensPredictionMore>>
1:1 orthologSostdc166042Q9CQN4CPOMus musculusPublicationMore>>
1:1 orthologSOSTDC1100736999F1SEJ1Sus scrofaPredictionMore>>
1:1 orthologSOSTDC1100354321G1T3J2Oryctolagus cuniculusPredictionMore>>
1:1 orthologSostdc1266803Q642G2Rattus norvegicusPredictionMore>>
1:1 orthologsostdc1a550261A7MCD1Danio rerioPredictionMore>>

Gene ontology

GO ID GO Term
GO:0005615 extracellular space
GO:0036122 BMP binding
GO:0098821 BMP receptor activity
GO:0031069 hair follicle morphogenesis
GO:0060648 mammary gland bud morphogenesis
GO:0030514 negative regulation of BMP signaling pathway
GO:0090090 negative regulation of canonical Wnt signaling pathway
GO:0010454 negative regulation of cell fate commitment
GO:2000016 negative regulation of determination of dorsal identity
GO:0045662 negative regulation of myoblast differentiation
GO:0042475 odontogenesis of dentin-containing tooth
GO:0007389 pattern specification process

Functional annotations

Keywords

Keyword ID Keyword Term
KW-1185 Reference proteome
KW-0732 Signal

Interpro

InterPro ID InterPro Term
IPR006207 Cys_knot_C
IPR029034 Cystine-knot_cytokine
IPR008835 Sclerostin/SOSTDC1

PROSITE

PROSITE ID PROSITE Term
PS01225 CTCK_2

Pfam

Pfam ID Pfam Term
PF05463 Sclerostin