Gene: wnt3

Basic information

Tag Content
Uniprot ID B0LK22
Entrez ID 569420
Genbank protein ID ACR15156.1; ABY60848.1;
Genbank nucleotide ID NM_001114552.2
Ensembl protein ID ENSDARP00000105032; ENSDARP00000153370;
Ensembl nucleotide ID ENSDARG00000111277; ENSDARG00000038990;
Gene name Protein Wnt
Gene symbol wnt3
Organism Danio rerio
NCBI taxa ID 7955
Cleft type
Developmental stage
Data sources Homology search
Reference
Functional description Ligand for members of the frizzled family of seven transmembrane receptors.
Sequence
MDLYLVGFLM CMWFSSSRVL GGYPIWWSLA LGQQYSSIGS QPILCGSIPG LVPKQLRFCR 60
NYIEIMPSVA EGVKLGIQEC QHQFRGRRWN CTTIKDSLAI FGPVLDKATR ESAFVHAIAS 120
AGVAFAVTRS CAEGTSTMCG CDSHHKGPPG EGWKWGGCSE DAEFGVLVSR EFADARENRP 180
DARSAMNRHN NEAGRMTILE NMHLRCKCHG LSGSCEVKTC WWAQPDFRLL GDYLKDKYDS 240
ASEMVVEKHR ESRGWVETLR AKYAFFKHPT ERDLVYYEGS PNFCEPNPET GSFGTRDRAC 300
NVSSHGIEGC DLLCCGRGHN TRTEKRKEKC HCIFHWCCYV SCQECVRVYD VHTCK 355

Abbreviation :
CLO : cleft lip only. CPO : cleft palate only. CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.

Protein disorder information

Orthologous information

Relation Gene symbol Entrez ID UniProt ID Cleft type Developmental stage Species Evidence Details
1:1 orthologWNT3A0A452F7A0Capra hircusPredictionMore>>
1:1 orthologWNT37473P56703CL/PHomo sapiensPublicationMore>>
1:1 orthologWnt322415P17553Mus musculusPredictionMore>>
1:1 orthologA0A4X1TEB6Sus scrofaPredictionMore>>
1:1 orthologWNT3100009033G1T851Oryctolagus cuniculusPredictionMore>>
1:1 orthologWnt324882D3ZCR1Rattus norvegicusPredictionMore>>
1:1 orthologwnt3569420B0LK22Danio rerioPredictionMore>>

Gene ontology

GO ID GO Term
GO:0005615 extracellular space
GO:0005125 cytokine activity
GO:0005109 frizzled binding
GO:0060070 canonical Wnt signaling pathway
GO:0045165 cell fate commitment
GO:0035844 cloaca development
GO:0030182 neuron differentiation
GO:0021794 thalamus development

Functional annotations

Keywords

Keyword ID Keyword Term
KW-0217 Developmental protein
KW-0272 Extracellular matrix
KW-0449 Lipoprotein
KW-1185 Reference proteome
KW-0964 Secreted
KW-0732 Signal
KW-0879 Wnt signaling pathway

Interpro

InterPro ID InterPro Term
IPR005817 Wnt
IPR009141 Wnt3
IPR043158 Wnt_C
IPR018161 Wnt_CS

PROSITE

PROSITE ID PROSITE Term
PS00246 WNT1

Pfam

Pfam ID Pfam Term
PF00110 wnt