| Tag | Content |
|---|---|
| Uniprot ID | D3ZCR1 |
| Entrez ID | 24882 |
| Genbank protein ID | EDM06286.1 |
| Genbank nucleotide ID | NM_001105715.1 |
| Ensembl protein ID | ENSRNOP00000005176 |
| Ensembl nucleotide ID | ENSRNOG00000003845 |
| Gene name | Protein Wnt |
| Gene symbol | Wnt3 |
| Organism | Rattus norvegicus |
| NCBI taxa ID | 10116 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | Ligand for members of the frizzled family of seven transmembrane receptors. |
| Sequence | MEPHLLGLLL GLLLSGTRVL AGYPIWWSLA LGQQYTSLAS QPLLCGSIPG LVPKQLRFCR 60 NYIEIMPSVA EGVKLGIQEC QHQFRGRRWN CTTIDDSLAI FGPVLDKATR ESAFVHAIAS 120 AGVAFAVTRS CAEGTSTICG CDSHHKGPPG EGWKWGGCSE DADFGVLVSR EFADARENRP 180 DARSAMNKHN NEAGRTTILD HMHLKCKCHG LSGSCEVKTC WWAQPDFRAI GDFLKDKYDS 240 ASEMVVEKHR ESRGWVETLR AKYALFKPPT ERDLVYYENS PNFCEPNPET GSFGTRDRTC 300 NVTSHGIDGC DLLCCGRGHN TRTEKRKEKC HCVFHWCCYV SCQECIRIYD VHTCK 355 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | WNT3 | A0A452F7A0 | Capra hircus | Prediction | More>> | |||
| 1:1 ortholog | WNT3 | 7473 | P56703 | CL/P | Homo sapiens | Publication | More>> | |
| 1:1 ortholog | Wnt3 | 22415 | P17553 | Mus musculus | Prediction | More>> | ||
| 1:1 ortholog | A0A4X1TEB6 | Sus scrofa | Prediction | More>> | ||||
| 1:1 ortholog | WNT3 | 100009033 | G1T851 | Oryctolagus cuniculus | Prediction | More>> | ||
| 1:1 ortholog | Wnt3 | 24882 | D3ZCR1 | Rattus norvegicus | Prediction | More>> | ||
| 1:1 ortholog | wnt3 | 569420 | B0LK22 | Danio rerio | Prediction | More>> |
| GO ID | GO Term |
|---|---|
| GO:0005737 | cytoplasm |
| GO:0031012 | extracellular matrix |
| GO:0005615 | extracellular space |
| GO:0005109 | frizzled binding |
| GO:0019904 | protein domain specific binding |
| GO:0048018 | receptor ligand activity |
| GO:0048646 | anatomical structure formation involved in morphogenesis |
| GO:0009948 | anterior/posterior axis specification |
| GO:0009952 | anterior/posterior pattern specification |
| GO:0007411 | axon guidance |
| GO:0060070 | canonical Wnt signaling pathway |
| GO:0044338 | canonical Wnt signaling pathway involved in mesenchymal stem cell differentiation |
| GO:1904954 | canonical Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation |
| GO:0044339 | canonical Wnt signaling pathway involved in osteoblast differentiation |
| GO:1905474 | canonical Wnt signaling pathway involved in stem cell proliferation |
| GO:0045165 | cell fate commitment |
| GO:0000902 | cell morphogenesis |
| GO:0009950 | dorsal/ventral axis specification |
| GO:0035115 | embryonic forelimb morphogenesis |
| GO:0035116 | embryonic hindlimb morphogenesis |
| GO:0007276 | gamete generation |
| GO:0060323 | head morphogenesis |
| GO:0060174 | limb bud formation |
| GO:0060173 | limb development |
| GO:0061180 | mammary gland epithelium development |
| GO:0001707 | mesoderm formation |
| GO:0048843 | negative regulation of axon extension involved in axon guidance |
| GO:0030182 | neuron differentiation |
| GO:0048697 | positive regulation of collateral sprouting in absence of injury |
| GO:0010628 | positive regulation of gene expression |
| GO:0030177 | positive regulation of Wnt signaling pathway |
| GO:0045595 | regulation of cell differentiation |
| GO:0001558 | regulation of cell growth |
| GO:0050767 | regulation of neurogenesis |
| GO:0060064 | Spemann organizer formation at the anterior end of the primitive streak |
| GO:0072089 | stem cell proliferation |
| GO:0016055 | Wnt signaling pathway |
| PROSITE ID | PROSITE Term |
|---|---|
| PS00246 | WNT1 |
| Pfam ID | Pfam Term |
|---|---|
| PF00110 | wnt |