| Tag | Content |
|---|---|
| Uniprot ID | P17553 |
| Entrez ID | 22415 |
| Genbank protein ID | AAB38109.1 |
| Genbank nucleotide ID | NM_009521.2 |
| Ensembl protein ID | ENSMUSP00000000127 |
| Ensembl nucleotide ID | ENSMUSG00000000125 |
| Gene name | Proto-oncogene Wnt-3 |
| Gene symbol | Wnt3 |
| Organism | Mus musculus |
| NCBI taxa ID | 10090 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | Ligand for members of the frizzled family of seven transmembrane receptors (Probable). Functions in the canonical Wnt signaling pathway that results in activation of transcription factors of the TCF/LEF family (By similarity). Required for normal gastrulation, formation of the primitive streak, and for the formation of the mesoderm during early embryogenesis (PubMed:10431240). Required for normal formation of the apical ectodermal ridge and for normal embryonic limb development (PubMed:12569130). |
| Sequence | MEPHLLGLLL GLLLSGTRVL AGYPIWWSLA LGQQYTSLAS QPLLCGSIPG LVPKQLRFCR 60 NYIEIMPSVA EGVKLGIQEC QHQFRGRRWN CTTIDDSLAI FGPVLDKATR ESAFVHAIAS 120 AGVAFAVTRS CAEGTSTICG CDSHHKGPPG EGWKWGGCSE DADFGVLVSR EFADARENRP 180 DARSAMNKHN NEAGRTTILD HMHLKCKCHG LSGSCEVKTC WWAQPDFRAI GDFLKDKYDS 240 ASEMVVEKHR ESRGWVETLR AKYALFKPPT ERDLVYYENS PNFCEPNPET GSFGTRDRTC 300 NVTSHGIDGC DLLCCGRGHN TRTEKRKEKC HCVFHWCCYV SCQECIRIYD VHTCK 355 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | WNT3 | A0A452F7A0 | Capra hircus | Prediction | More>> | |||
| 1:1 ortholog | WNT3 | 7473 | P56703 | CL/P | Homo sapiens | Publication | More>> | |
| 1:1 ortholog | Wnt3 | 22415 | P17553 | Mus musculus | Prediction | More>> | ||
| 1:1 ortholog | A0A4X1TEB6 | Sus scrofa | Prediction | More>> | ||||
| 1:1 ortholog | WNT3 | 100009033 | G1T851 | Oryctolagus cuniculus | Prediction | More>> | ||
| 1:1 ortholog | Wnt3 | 24882 | D3ZCR1 | Rattus norvegicus | Prediction | More>> | ||
| 1:1 ortholog | wnt3 | 569420 | B0LK22 | Danio rerio | Prediction | More>> |
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0005102 | signaling receptor binding | TAS |
| GO:0005109 | frizzled binding | ISO |
| GO:0005109 | frizzled binding | IBA |
| GO:0005515 | protein binding | IPI |
| GO:0019904 | protein domain specific binding | IPI |
| GO:0048018 | receptor ligand activity | ISO |
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0000902 | cell morphogenesis | ISO |
| GO:0001707 | mesoderm formation | IMP |
| GO:0007165 | signal transduction | TAS |
| GO:0007267 | cell-cell signaling | TAS |
| GO:0007276 | gamete generation | IGI |
| GO:0007411 | axon guidance | IDA |
| GO:0009887 | animal organ morphogenesis | TAS |
| GO:0009948 | anterior/posterior axis specification | IMP |
| GO:0009950 | dorsal/ventral axis specification | IMP |
| GO:0009952 | anterior/posterior pattern specification | IMP |
| GO:0010628 | positive regulation of gene expression | ISO |
| GO:0010628 | positive regulation of gene expression | IDA |
| GO:0016055 | Wnt signaling pathway | IBA |
| GO:0030177 | positive regulation of Wnt signaling pathway | IDA |
| GO:0030182 | neuron differentiation | IBA |
| GO:0035115 | embryonic forelimb morphogenesis | IMP |
| GO:0035116 | embryonic hindlimb morphogenesis | IMP |
| GO:0044338 | canonical Wnt signaling pathway involved in mesenchymal stem cell differentiation | ISO |
| GO:0044339 | canonical Wnt signaling pathway involved in osteoblast differentiation | ISO |
| GO:0045165 | cell fate commitment | IBA |
| GO:0048646 | anatomical structure formation involved in morphogenesis | IMP |
| GO:0048697 | positive regulation of collateral sprouting in absence of injury | IDA |
| GO:0048843 | negative regulation of axon extension involved in axon guidance | IDA |
| GO:0050767 | regulation of neurogenesis | ISO |
| GO:0060064 | Spemann organizer formation at the anterior end of the primitive streak | IMP |
| GO:0060070 | canonical Wnt signaling pathway | ISO |
| GO:0060070 | canonical Wnt signaling pathway | IGI |
| GO:0060173 | limb development | IMP |
| GO:0060174 | limb bud formation | ISO |
| GO:0060323 | head morphogenesis | IGI |
| GO:0061180 | mammary gland epithelium development | IEA |
| GO:0072089 | stem cell proliferation | ISO |
| GO:1904954 | canonical Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation | ISO |
| GO:1905474 | canonical Wnt signaling pathway involved in stem cell proliferation | ISO |
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0005615 | extracellular space | IBA |
| GO:0005737 | cytoplasm | ISO |
| GO:0005788 | endoplasmic reticulum lumen | TAS |
| GO:0031012 | extracellular matrix | IDA |
| Reactome ID | Reactome Term | Evidence |
|---|---|---|
| R-MMU-162582 | Signal Transduction | IEA |
| R-MMU-195721 | Signaling by WNT | IEA |
| R-MMU-201681 | TCF dependent signaling in response to WNT | IEA |
| R-MMU-3238698 | WNT ligand biogenesis and trafficking | IEA |
| PROSITE ID | PROSITE Term |
|---|---|
| PS00246 | WNT1 |
| Pfam ID | Pfam Term |
|---|---|
| PF00110 | wnt |