| Tag | Content |
|---|---|
| Uniprot ID | B2GUZ3 |
| Entrez ID | 361472 |
| Genbank protein ID | AAI66462.1 |
| Genbank nucleotide ID | NM_001108462.2 |
| Ensembl protein ID | ENSRNOP00000026564 |
| Ensembl nucleotide ID | ENSRNOG00000019582 |
| Gene name | Methylenetetrahydrofolate dehydrogenase (NADP+-dependent) 1-like |
| Gene symbol | Mthfd1l |
| Organism | Rattus norvegicus |
| NCBI taxa ID | 10116 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | |
| Sequence | MSARLPLLLR QLGHQQLPPG PACRLRELCR SGSRSSSSGG GDPEGLRGRR LQDGQAFISH 60 SPGSPEDPGM DSIVRDVIHN SKEVLNLLQE KNPAFKPVLA VIQAGDDHLM QNVNQNLAKE 120 AGLDITHICL PPDSGEDEII DEILKINEDP RVHGLALQIS EDSLCNKVLN ALKPEKDVDG 180 VTDVNLGKLV RGDAPECFVS PLARAAVELI EKSGITLDGK KVLVIGAHGP LEAALQCLFQ 240 RKGSMTMSSP WITPQLQDKL READIVVLGS PKPDEIPAAW IPSGATMLNC FHDFLSGKLR 300 GGSPGVPMNR LIADESVSLL AAALRVQNMV NSGRRWLREQ QHRRWRLHCL KLQPLSPVPS 360 DIEISRGQTP KAVDVLAKEI GLLADEIEIY GKSKAKVRLS LLERLKDQTD GKYVLVAGIT 420 PTPLGEGKST VTIGLVQALT AHLNVNSFAC LRQPSQGPTF GVKGGAAGGG YAQVIPMEEF 480 NLHLTGDIHA ITAANNLLAA AIDTRIFHES TQTDKALYNR LVPLVNGVRK FSEIQLSRLK 540 KLGIHKTDPT ALTEEEVRKF TRLNIDPSTI TWQRVLDTND RFLRKITIGQ GSTEKGYSRQ 600 AQFDIAVASE IMAVLALTDS LADMKERLGR MVVASDKDGQ PVTAEDLGVT GALTVLMKDA 660 IKPNLMQTLE GTPVFVHAGP FANIAHGNSS VLADKIALKL VGEEGFVVTE AGFGADIGME 720 KFFNIKCRAS GLVPNVVVLV ATVRALKMHG GGPSVTAGVP LKKEYTEENI QLVADGCCNL 780 QKQIQIAQLF GVPVVVALNV FKTDTRAEID LVCELAKRAG AFDAVPCYHW SAGGKGSVDL 840 ARAVREAANK RSRFRFLYDV QLPIVAKIRV IAQTVYGAKD IELSPEAQAK IDRYTQQGFG 900 NLPICMAKTH LSLSHEPDKK GVPRDFILPI SDVRASIGAG FIYPLVGMMS TMPGLPTRPC 960 FYDIDLDTET EQVKGLF 977 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | MTHFD1L | 102188948 | A0A452G6W1 | Capra hircus | Prediction | More>> | ||
| 1:1 ortholog | MTHFD1L | 25902 | B7ZM99 | Homo sapiens | Prediction | More>> | ||
| 1:1 ortholog | Mthfd1l | 270685 | Q3V3R1 | CPO | Mus musculus | Publication | More>> | |
| 1:1 ortholog | H2QTW9 | Pan troglodytes | Prediction | More>> | ||||
| 1:1 ortholog | MTHFD1L | F1S7V9 | Sus scrofa | Prediction | More>> | |||
| 1:1 ortholog | Mthfd1l | 361472 | B2GUZ3 | Rattus norvegicus | Prediction | More>> | ||
| 1:1 ortholog | mthfd1l | 100034522 | F1QQ79 | Danio rerio | Prediction | More>> |
| GO ID | GO Term |
|---|---|
| GO:0005737 | cytoplasm |
| GO:0005739 | mitochondrion |
| GO:0005524 | ATP binding |
| GO:0004329 | formate-tetrahydrofolate ligase activity |
| GO:0004488 | methylenetetrahydrofolate dehydrogenase (NADP+) activity |
| GO:0042803 | protein homodimerization activity |
| GO:0009257 | 10-formyltetrahydrofolate biosynthetic process |
| GO:0048702 | embryonic neurocranium morphogenesis |
| GO:0048703 | embryonic viscerocranium morphogenesis |
| GO:0006760 | folic acid-containing compound metabolic process |
| GO:0015942 | formate metabolic process |
| GO:0001843 | neural tube closure |
| GO:0009113 | purine nucleobase biosynthetic process |