| Tag | Content |
|---|---|
| Uniprot ID | F1QQ79 |
| Entrez ID | 100034522 |
| Genbank protein ID | |
| Genbank nucleotide ID | XM_005160551.3; XM_005160552.3; NM_001242996.1; |
| Ensembl protein ID | ENSDARP00000061913; ENSDARP00000154669; |
| Ensembl nucleotide ID | ENSDARG00000042221 |
| Gene name | Formyltetrahydrofolate synthetase |
| Gene symbol | mthfd1l |
| Organism | Danio rerio |
| NCBI taxa ID | 7955 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | |
| Sequence | MMRLSVAFRH ARRSHSTIQR SRTCVKFLSR ENRHTPDISA VSFLRAREAS STSGTTETAA 60 SLQSHARKYE GPPYERAVGD IVQRCREELK SIGENNPGLK PTLAIIQAGE DDGLLEMNKK 120 MAGKIGLNVM QICLPHRCTE EEVIEEVLRL NKDSRVHGIF LHLPQTFLSK SVRNAIKPQK 180 DVDGVCDLNV GRVVLGDKTD GFTSPVAGAV LELLAKHDAP LVGKMAVLVG LEGPLKVALQ 240 CLLQNNGMIL QTCRWSSTNL QKQIMDSDVV ITLNTNQNHI PSTWLRPGVA AINLGSALLE 300 EHPDSWEATV EAQSAAGLGP LTAAFRMQHV VRSSRRWIQE QQYQPWNIRP LKLHPLSPVP 360 SDIEISRAQT PKPISQLAQE IGLLPEELEA YGNTKAKVHL SLLNRLQHQP DGRYVLVAGI 420 TPTPLGEGKS TVTIGLAQAL TAHLKLNSFA CLRQPSQGPT FGVKGGAAGG GYAQVIPMEE 480 FNLHLTGDIH AITAANNLVA AAIDARILHE ATQSDKALYS RLVPSVNGVR RFSPIQLARL 540 QRLGINKSNP TDLTPQEVSA FVRLDLDPEK VTWQRVVDTN DRFLRKITIG QANTEKGHAR 600 QTQFDIAVAS EIMAILALTD GLADMRARLG RMVVGSSRNG QAITADDLGV TGALAVLMKD 660 AIKPTLMQTL EGTPVFVHAG PFANIAHGNS SVLADKLALK LVGEEGYVVT EAGFGADIGM 720 EKFFNIKCRT SGLRPNVVVL VATIRALKMH GGGPNVTAGA PLPKEYIEEN LQLVADGCSN 780 LKKQIQIAHL FGVPVVVALN AFKTDTQAEI DLVCRIAKAS GASAAVPCHH WSRGGRGSLE 840 LAHAVKEVAA QGSRFQFLYN LQDPIVEKIR TIAQKVYGAE DIELSSEAQA KIDYYNQQGF 900 GALPICMAKT HLSLSHMPEK KGVPTNFILP IRDVRASIGA GFIYPLVGTM STMPGLPTRP 960 CFYDIDLDPV TEEIKGLF 978 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | MTHFD1L | 102188948 | A0A452G6W1 | Capra hircus | Prediction | More>> | ||
| 1:1 ortholog | MTHFD1L | 25902 | B7ZM99 | Homo sapiens | Prediction | More>> | ||
| 1:1 ortholog | Mthfd1l | 270685 | Q3V3R1 | CPO | Mus musculus | Publication | More>> | |
| 1:1 ortholog | H2QTW9 | Pan troglodytes | Prediction | More>> | ||||
| 1:1 ortholog | MTHFD1L | F1S7V9 | Sus scrofa | Prediction | More>> | |||
| 1:1 ortholog | Mthfd1l | 361472 | B2GUZ3 | Rattus norvegicus | Prediction | More>> | ||
| 1:1 ortholog | mthfd1l | 100034522 | F1QQ79 | Danio rerio | Prediction | More>> |
| GO ID | GO Term |
|---|---|
| GO:0005829 | cytosol |
| GO:0005524 | ATP binding |
| GO:0004329 | formate-tetrahydrofolate ligase activity |
| GO:0004477 | methenyltetrahydrofolate cyclohydrolase activity |
| GO:0004488 | methylenetetrahydrofolate dehydrogenase (NADP+) activity |
| GO:0035999 | tetrahydrofolate interconversion |