Gene: Pbx1

Basic information

Tag Content
Uniprot ID D3ZJI6
Entrez ID
Genbank protein ID
Genbank nucleotide ID
Ensembl protein ID ENSRNOP00000039416
Ensembl nucleotide ID ENSRNOG00000004693
Gene name PBX homeobox 1
Gene symbol Pbx1
Organism Rattus norvegicus
NCBI taxa ID 10116
Cleft type
Developmental stage
Data sources Homology search
Reference
Functional description
Sequence
VLSIRGAQEE EPTDPQLMRL DNMLLAEGVA GPEKGGGSAA AAAAAAASGG AGSDNSVEHS 60
DYRAKLSQIR QIYHTELEKY EQACNEFTTH VMNLLREQSR TRPISPKEIE RMVSIIHRKF 120
SSIQMQLKQS TCEAVMILRS RFLDARRKRR NFNKQATEIL NEYFYSHLSN PYPSEEAKEE 180
LAKKCGITVS QVSNWFGNKR IRYKKNIGKF QEEANIYAAK TAVTATNVSA HGSQANSPST 240
PNSAGSSSSF NMSNSGDLFM SVQSLNGDSY QGAQVGANVQ SQVDTLRHVI SQTGGYSDGL 300
AASQMYSPQG ISANGGWQDA TTPSSVTSPT EGPGSVHSDT SN 342

Abbreviation :
CLO : cleft lip only. CPO : cleft palate only. CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.

Protein disorder information

Orthologous information

Relation Gene symbol Entrez ID UniProt ID Cleft type Developmental stage Species Evidence Details
1:1 orthologPBX1F1PDM8Canis lupus familiarisPredictionMore>>
1:1 orthologPBX1A0A452FB79Capra hircusPredictionMore>>
1:1 orthologPBX15087P40424Homo sapiensPredictionMore>>
1:1 orthologPbx118514P41778CPO,CLP,CLOE13.5Mus musculusPublicationMore>>
1:1 orthologPBX1457474A0A2I3RPY9Pan troglodytesPredictionMore>>
1:1 orthologPbx1D3ZJI6Rattus norvegicusPredictionMore>>

Gene ontology

GO ID GO Term
GO:0005737 cytoplasm
GO:0005654 nucleoplasm
GO:0005634 nucleus
GO:0090575 RNA polymerase II transcription factor complex
GO:0005667 transcription factor complex
GO:0003677 DNA binding
GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific
GO:0046982 protein heterodimerization activity
GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0043565 sequence-specific DNA binding
GO:0008134 transcription factor binding
GO:0030325 adrenal gland development
GO:0009887 animal organ morphogenesis
GO:0009952 anterior/posterior pattern specification
GO:0001658 branching involved in ureteric bud morphogenesis
GO:0035162 embryonic hemopoiesis
GO:0030326 embryonic limb morphogenesis
GO:0048568 embryonic organ development
GO:0048706 embryonic skeletal system development
GO:0043433 negative regulation of DNA-binding transcription factor activity
GO:0045665 negative regulation of neuron differentiation
GO:0008284 positive regulation of cell population proliferation
GO:0010971 positive regulation of G2/M transition of mitotic cell cycle
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0009954 proximal/distal pattern formation
GO:0042127 regulation of cell population proliferation
GO:0030278 regulation of ossification
GO:0048536 spleen development
GO:0048538 thymus development
GO:0001655 urogenital system development

Functional annotations

Keywords

Keyword ID Keyword Term
KW-0175 Coiled coil
KW-0238 DNA-binding
KW-0371 Homeobox
KW-0539 Nucleus
KW-1185 Reference proteome

Interpro

InterPro ID InterPro Term
IPR009057 Homeobox-like_sf
IPR017970 Homeobox_CS
IPR001356 Homeobox_dom
IPR005542 PBX

PROSITE

PROSITE ID PROSITE Term
PS00027 HOMEOBOX_1
PS50071 HOMEOBOX_2

Pfam

Pfam ID Pfam Term
PF00046 Homeodomain
PF03792 PBC