Gene: Tiparp

Basic information

Tag Content
Uniprot ID D3ZMH5
Entrez ID 310467
Genbank protein ID EDM00942.1
Genbank nucleotide ID XM_003749294.4; XM_003753596.4;
Ensembl protein ID ENSRNOP00000015387
Ensembl nucleotide ID ENSRNOG00000011238
Gene name TCDD-inducible poly(ADP-ribose) polymerase
Gene symbol Tiparp
Organism Rattus norvegicus
NCBI taxa ID 10116
Cleft type
Developmental stage
Data sources Homology search
Reference
Functional description
Sequence
MDMETTDPEP DCVVQPPSPP DDFSCQMRIS EKITPLKTCF KKKQEQKRLG TGTLRSLRPI 60
LNTLLESGSL DGVFRARDQN GDESSLHEHI VKKPLDINPA CPPAENSMPV LIPDGTNVEG 120
QLPEAHPSTD APEQVVPIQD HSFPPETING TVADSTTGHF QTDLLHPVSG DVPTSPDCID 180
KVMDYVPGAF QDNSFTIQYI LDTSDKLSTE LFQDKSEEAS LDLVFELVNQ LQYHTHQETG 240
IEICMDFLQG TCIYGRDCLK HHTVLPYHWQ IKRTTTQKWQ SVSNDSQEHL ERFYCNPEND 300
RMRMKYGGQD FWADLNAMTV FETTEFDQLR RLSTPPCSST NSIYHTFWKF FCRDHFGWRE 360
YPESVVRLIE EANSRGLKEV RFMMWNNHYI LHNSFFRREI KRRPLFRSCF ILIPYLQTLG 420
GVPTQASLPL EATSSQIICP DGVTSANFYP ETWVYMHPSQ DFIQVPVSAE DKSYRIIYNL 480
FHKTVPEFKY RILQILRVQN QFLWEKYKRK KEYMNRKMSG RDRIINERHL FHGTSQDVVD 540
GICKHNFDPR VCGKHATMFG QGSYFAKKAS YSHNFSKKSS KGVHFMFLAK VLTGRYTMGS 600
HGMRRPPPVN PGSVTSDLYD SCVDNFFEPQ IFVIFNDDQS YPYFVIQYEE VSNTVSI 657

Abbreviation :
CLO : cleft lip only. CPO : cleft palate only. CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.

Protein disorder information

Orthologous information

Relation Gene symbol Entrez ID UniProt ID Cleft type Developmental stage Species Evidence Details
1:1 orthologTIPARP102182170A0A452F6F5Capra hircusPredictionMore>>
1:1 orthologTIPARP25976Q7Z3E1Homo sapiensPredictionMore>>
1:1 orthologTiparp99929Q8C1B2CPOMus musculusPublicationMore>>
1:1 orthologTIPARP460801H2QNM7Pan troglodytesPredictionMore>>
1:1 orthologTIPARP100626111I3LQD6Sus scrofaPredictionMore>>
1:1 orthologTIPARPG1T8C7Oryctolagus cuniculusPredictionMore>>
1:1 orthologTiparp310467D3ZMH5Rattus norvegicusPredictionMore>>
1:1 orthologtiparpF8W3Q5Danio rerioPredictionMore>>

Gene ontology

GO ID GO Term
GO:0005634 nucleus
GO:0035326 cis-regulatory region binding
GO:0046872 metal ion binding
GO:0003950 NAD+ ADP-ribosyltransferase activity
GO:1990404 protein ADP-ribosylase activity
GO:0008209 androgen metabolic process
GO:0071407 cellular response to organic cyclic compound
GO:0008210 estrogen metabolic process
GO:0060325 face morphogenesis
GO:0008585 female gonad development
GO:0030097 hemopoiesis
GO:0001822 kidney development
GO:0010629 negative regulation of gene expression
GO:0006807 nitrogen compound metabolic process
GO:0048008 platelet-derived growth factor receptor signaling pathway
GO:0045732 positive regulation of protein catabolic process
GO:0009791 post-embryonic development
GO:0006471 protein ADP-ribosylation
GO:0070213 protein auto-ADP-ribosylation
GO:0140289 protein mono-ADP-ribosylation
GO:1904612 response to 2,3,7,8-tetrachlorodibenzodioxine
GO:0060021 roof of mouth development
GO:0048705 skeletal system morphogenesis
GO:0048745 smooth muscle tissue development
GO:0001570 vasculogenesis

Functional annotations

Keywords

Keyword ID Keyword Term
KW-0479 Metal-binding
KW-1185 Reference proteome
KW-0862 Zinc
KW-0863 Zinc-finger

Interpro

InterPro ID InterPro Term
IPR012317 Poly(ADP-ribose)pol_cat_dom
IPR004170 WWE-dom
IPR037197 WWE_dom_sf
IPR000571 Znf_CCCH

PROSITE

PROSITE ID PROSITE Term
PS51059 PARP_CATALYTIC
PS50918 WWE
PS50103 ZF_C3H1

Pfam

Pfam ID Pfam Term
PF00644 PARP