Gene: TIPARP

Basic information

Tag Content
Uniprot ID Q7Z3E1; D3DNK6; Q68CY9; Q86VP4; Q9Y4P7;
Entrez ID 25976
Genbank protein ID AAH50350.2; CAB45747.2; EAW78725.1; EAW78728.1; CAH18441.1; CAD97929.1;
Genbank nucleotide ID NM_001184717.1; NM_001184718.1; NM_015508.4;
Ensembl protein ID ENSP00000418757; ENSP00000438345; ENSP00000295924; ENSP00000420612;
Ensembl nucleotide ID ENSG00000163659
Gene name Protein mono-ADP-ribosyltransferase TIPARP
Gene symbol TIPARP
Organism Homo sapiens
NCBI taxa ID 9606
Cleft type
Developmental stage
Data sources Homology search
Reference
Functional description ADP-ribosyltransferase that mediates mono-ADP-ribosylation of glutamate, aspartate and cysteine residues on target proteins (PubMed:23275542, PubMed:25043379, PubMed:30373764). Acts as a negative regulator of AHR by mediating mono-ADP-ribosylation of AHR, leading to inhibit transcription activator activity of AHR (PubMed:23275542, PubMed:30373764).
Sequence
MEMETTEPEP DCVVQPPSPP DDFSCQMRLS EKITPLKTCF KKKDQKRLGT GTLRSLRPIL 60
NTLLESGSLD GVFRSRNQST DENSLHEPMM KKAMEINSSC PPAENNMSVL IPDRTNVGDQ 120
IPEAHPSTEA PERVVPIQDH SFPSETLSGT VADSTPAHFQ TDLLHPVSSD VPTSPDCLDK 180
VIDYVPGIFQ ENSFTIQYIL DTSDKLSTEL FQDKSEEASL DLVFELVNQL QYHTHQENGI 240
EICMDFLQGT CIYGRDCLKH HTVLPYHWQI KRTTTQKWQS VFNDSQEHLE RFYCNPENDR 300
MRMKYGGQEF WADLNAMNVY ETTEFDQLRR LSTPPSSNVN SIYHTVWKFF CRDHFGWREY 360
PESVIRLIEE ANSRGLKEVR FMMWNNHYIL HNSFFRREIK RRPLFRSCFI LLPYLQTLGG 420
VPTQAPPPLE ATSSSQIICP DGVTSANFYP ETWVYMHPSQ DFIQVPVSAE DKSYRIIYNL 480
FHKTVPEFKY RILQILRVQN QFLWEKYKRK KEYMNRKMFG RDRIINERHL FHGTSQDVVD 540
GICKHNFDPR VCGKHATMFG QGSYFAKKAS YSHNFSKKSS KGVHFMFLAK VLTGRYTMGS 600
HGMRRPPPVN PGSVTSDLYD SCVDNFFEPQ IFVIFNDDQS YPYFVIQYEE VSNTVSI 657

Abbreviation :
CLO : cleft lip only. CPO : cleft palate only. CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.

Gene expression information

Gene expression in different tissues (GTEx V7)

  

Gene expression in different tissues (ENCODE)

  

Protein structural annotations

3D structure in PDB database

There is no related protein structure for this gene.

Protein disorder information

Orthologous information

Relation Gene symbol Entrez ID UniProt ID Cleft type Developmental stage Species Evidence Details
1:1 orthologTIPARP102182170A0A452F6F5Capra hircusPredictionMore>>
1:1 orthologTIPARP25976Q7Z3E1Homo sapiensPredictionMore>>
1:1 orthologTiparp99929Q8C1B2CPOMus musculusPublicationMore>>
1:1 orthologTIPARP460801H2QNM7Pan troglodytesPredictionMore>>
1:1 orthologTIPARP100626111I3LQD6Sus scrofaPredictionMore>>
1:1 orthologTIPARPG1T8C7Oryctolagus cuniculusPredictionMore>>
1:1 orthologTiparp310467D3ZMH5Rattus norvegicusPredictionMore>>
1:1 orthologtiparpF8W3Q5Danio rerioPredictionMore>>

Other genetic variants/mutations

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Disease or phenotype associated information

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Gene Ontology (GO)/biological pathways

GO:Molecular Function

GO ID GO Term Evidence
GO:0003950 NAD+ ADP-ribosyltransferase activityIDA
GO:0035326 cis-regulatory region bindingIDA
GO:0046872 metal ion bindingIEA
GO:1990404 protein ADP-ribosylase activityIDA

GO:Biological Process

GO ID GO Term Evidence
GO:0001570 vasculogenesisIEA
GO:0001822 kidney developmentIEA
GO:0006471 protein ADP-ribosylationIDA
GO:0008209 androgen metabolic processIEA
GO:0008210 estrogen metabolic processIEA
GO:0008585 female gonad developmentIEA
GO:0009791 post-embryonic developmentIEA
GO:0010629 negative regulation of gene expressionIMP
GO:0030097 hemopoiesisIEA
GO:0045732 positive regulation of protein catabolic processIMP
GO:0048008 platelet-derived growth factor receptor signaling pathwayIEA
GO:0048705 skeletal system morphogenesisIEA
GO:0048745 smooth muscle tissue developmentIEA
GO:0060021 roof of mouth developmentIEA
GO:0060325 face morphogenesisIEA
GO:0070213 protein auto-ADP-ribosylationIDA
GO:0071407 cellular response to organic cyclic compoundIDA
GO:0140289 protein mono-ADP-ribosylationIDA
GO:1904612 response to 2,3,7,8-tetrachlorodibenzodioxineIEA

GO:Cellular Component

GO ID GO Term Evidence
GO:0005634 nucleusIDA

Reactome Pathway

Reactome ID Reactome Term Evidence

Drugs and compounds information

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Functional annotations

Keywords

Keyword ID Keyword Term
KW-0013 ADP-ribosylation
KW-0328 Glycosyltransferase
KW-0479 Metal-binding
KW-0520 NAD
KW-0539 Nucleus
KW-0621 Polymorphism
KW-1185 Reference proteome
KW-0808 Transferase
KW-0862 Zinc
KW-0863 Zinc-finger

Interpro

InterPro ID InterPro Term
IPR012317 Poly(ADP-ribose)pol_cat_dom
IPR004170 WWE-dom
IPR037197 WWE_dom_sf
IPR000571 Znf_CCCH

PROSITE

PROSITE ID PROSITE Term
PS51059 PARP_CATALYTIC
PS50918 WWE
PS50103 ZF_C3H1

Pfam

Pfam ID Pfam Term
PF00644 PARP

Protein-protein interaction

Protein-miRNA interaction