Gene: Tiparp

Basic information

Tag Content
Uniprot ID Q8C1B2; Q3UD50; Q8C032;
Entrez ID 99929
Genbank protein ID BAE29412.1; BAC27876.1; BAC25994.1; BAE36720.1; AAH68173.1;
Genbank nucleotide ID NM_178892.5
Ensembl protein ID ENSMUSP00000048051
Ensembl nucleotide ID ENSMUSG00000034640
Gene name Protein mono-ADP-ribosyltransferase TIPARP
Gene symbol Tiparp
Organism Mus musculus
NCBI taxa ID 10090
Cleft type CPO
Developmental stage
Data sources Manually collected
Reference 17143286
Functional description ADP-ribosyltransferase that mediates mono-ADP-ribosylation of glutamate, aspartate and cysteine residues on target proteins (By similarity). Acts as a negative regulator of AHR by mediating mono-ADP-ribosylation of AHR, leading to inhibit transcription activator activity of AHR (Probable).
Sequence
MEVETTEPEP DCVVQPPSPS DDFSCQMRIS EKISPLKTCF KKKQEQKRLG TGTLRSLRPI 60
LNTLLESGSL DGVFRARDQN RDESSLHEHI VKKPLEINPS CPPAENSMPV LIPDGTNVEG 120
QLPEAHPSTD APEQGVPIQD HSFPPETISG TVADSTTGHF QTDLLHPVSG DVPTSPDCVD 180
KVMDYVPGAF QDNSFTIQYI LDTSDKLSTE LFQDKSEEAS LELVFELVNQ LQYHTHQENG 240
IEICMDFLQG TCIYGRDCLK HHTVLPYHWQ IKRTTTQKWQ SVSNDSQEHL ERFYCNPEND 300
RMRMKYGGQD FWADLNAMTV FETTEFDQLR RLSTPPCSNS NSIYHTFWKF FCRDHFGWRE 360
YPESVVRLIE EANSRGLKEV RFMMWNNHYI LHNSFFRREI KRRPLFRSCF ILIPYLQTLG 420
GVPTQASLPL EATSSQIICP DGVTSANFYP ETWVYMHPSQ DFIQVPVSAE DKSYRIIYNL 480
FHKTVPEFKY RILQILRVQN QFLWEKYKRK KEYMNRKMSG RDRIINERHL FHGTSQDVVD 540
GICKHNFDPR VCGKHATMFG QGSYFAKKAS YSHNFSKKSS KGVHFMFLAK VLTGRYTMGS 600
HGMRRPPPVN PGSVTSDLYD SCVDNFFEPQ IFVIFNDDQS YPYFVIQYEE VSNTVSI 657

Abbreviation :
CLO : cleft lip only. CPO : cleft palate only. CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.

Protein structural annotations

3D structure in PDB database

There is no related protein structure for this gene.

Protein disorder information

Orthologous information

Relation Gene symbol Entrez ID UniProt ID Cleft type Developmental stage Species Evidence Details
1:1 orthologTIPARP102182170A0A452F6F5Capra hircusPredictionMore>>
1:1 orthologTIPARP25976Q7Z3E1Homo sapiensPredictionMore>>
1:1 orthologTiparp99929Q8C1B2CPOMus musculusPublicationMore>>
1:1 orthologTIPARP460801H2QNM7Pan troglodytesPredictionMore>>
1:1 orthologTIPARP100626111I3LQD6Sus scrofaPredictionMore>>
1:1 orthologTIPARPG1T8C7Oryctolagus cuniculusPredictionMore>>
1:1 orthologTiparp310467D3ZMH5Rattus norvegicusPredictionMore>>
1:1 orthologtiparpF8W3Q5Danio rerioPredictionMore>>

Other genetic variants/mutations

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Gene Ontology (GO)/biological pathways

GO:Molecular Function

GO ID GO Term Evidence
GO:0003950 NAD+ ADP-ribosyltransferase activityIDA
GO:0003950 NAD+ ADP-ribosyltransferase activityISO
GO:0035326 cis-regulatory region bindingISO
GO:0046872 metal ion bindingIEA
GO:1990404 protein ADP-ribosylase activityISS
GO:1990404 protein ADP-ribosylase activityISO

GO:Biological Process

GO ID GO Term Evidence
GO:0001570 vasculogenesisIMP
GO:0001822 kidney developmentIMP
GO:0006471 protein ADP-ribosylationISO
GO:0006471 protein ADP-ribosylationIDA
GO:0006807 nitrogen compound metabolic processIMP
GO:0008209 androgen metabolic processIMP
GO:0008210 estrogen metabolic processIMP
GO:0008585 female gonad developmentIMP
GO:0009791 post-embryonic developmentIMP
GO:0010629 negative regulation of gene expressionISO
GO:0030097 hemopoiesisIMP
GO:0045732 positive regulation of protein catabolic processISO
GO:0048008 platelet-derived growth factor receptor signaling pathwayIMP
GO:0048705 skeletal system morphogenesisIMP
GO:0048745 smooth muscle tissue developmentIMP
GO:0060021 roof of mouth developmentIMP
GO:0060325 face morphogenesisIMP
GO:0070213 protein auto-ADP-ribosylationISS
GO:0070213 protein auto-ADP-ribosylationISO
GO:0071407 cellular response to organic cyclic compoundISO
GO:0140289 protein mono-ADP-ribosylationISS
GO:0140289 protein mono-ADP-ribosylationISO
GO:1904612 response to 2,3,7,8-tetrachlorodibenzodioxineIEA

GO:Cellular Component

GO ID GO Term Evidence
GO:0005634 nucleusISS
GO:0005634 nucleusISO

Reactome Pathway

Reactome ID Reactome Term Evidence

Functional annotations

Keywords

Keyword ID Keyword Term
KW-0013 ADP-ribosylation
KW-0328 Glycosyltransferase
KW-0479 Metal-binding
KW-0520 NAD
KW-0539 Nucleus
KW-1185 Reference proteome
KW-0808 Transferase
KW-0862 Zinc
KW-0863 Zinc-finger

Interpro

InterPro ID InterPro Term
IPR012317 Poly(ADP-ribose)pol_cat_dom
IPR004170 WWE-dom
IPR037197 WWE_dom_sf
IPR000571 Znf_CCCH

PROSITE

PROSITE ID PROSITE Term
PS51059 PARP_CATALYTIC
PS50918 WWE
PS50103 ZF_C3H1

Pfam

Pfam ID Pfam Term
PF00644 PARP

Protein-miRNA interaction