| Tag | Content |
|---|---|
| Uniprot ID | D3ZMK6 |
| Entrez ID | 302369 |
| Genbank protein ID | EDM07111.1 |
| Genbank nucleotide ID | XM_006257162.3; NM_001106937.1; |
| Ensembl protein ID | ENSRNOP00000003190 |
| Ensembl nucleotide ID | ENSRNOG00000002346 |
| Gene name | Similar to T-box 22 isoform 1 |
| Gene symbol | Tbx22 |
| Organism | Rattus norvegicus |
| NCBI taxa ID | 10116 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | |
| Sequence | MALSSRAHAF SVEALMGRPS KRKAQDPREE MQPELQEEQF IEEGEEILSS PSGDSEQPEK 60 RPKAESSKTV FSCSDNESNS LESLLEESII QVELQGSDLW KRFHDIGTEM IITKAGRRMF 120 PSVRIKVKGM DPVKQYYVIL DVVPVDSKRY RYVYHSSQWM VAGNTDHSCI TPRFYVHPDS 180 PCSGENWMRQ IISFDRVKLT NNEMDDKGHI ILQSMHKYKP RVHVVEEDSR IDLSLIQSFP 240 TEGVKTFSFK ETEFTTVTAY QNQQITKLKI DRNPFAKGFR DPGRNRGVLD GFLETYPWRP 300 SFTMDFKPFV PDTQNGSSGS SPVTSSGGAP SPLNSLLSPS CSPPTVYIPP SSIGMTHPET 360 YLHNVNVPFC YRICPTNYWR PQPFVLPTPE RLPSFNSSQS FPPLMMEVPL VSSRGFINSN 420 SGLHEDCNGH CLQASHSTSQ MLYGLQNPGN IFHPNPIAQE AICCPFHPPN GCYRYNVSMP 480 PRLENVANHL SENGTNQISF TGGSCDHSHW YPAINHYF 518 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | TBX22 | 100299988 | G3N243 | Bos taurus | Prediction | More>> | ||
| 1:1 ortholog | TBX22 | A0A452EVR5 | Capra hircus | Prediction | More>> | |||
| 1:1 ortholog | TBX22 | 50945 | Q9Y458 | CPO,CL/P | Homo sapiens | Publication | More>> | |
| 1:1 ortholog | Tbx22 | 245572 | Q8K402 | CPO | E11.5, E12.5, E14.0, E13.5, E14.5 | Mus musculus | Publication | More>> |
| 1:1 ortholog | TBX22 | 473683 | A0A2J8KJZ2 | Pan troglodytes | Prediction | More>> | ||
| 1:1 ortholog | A0A4X1W2E6 | Sus scrofa | Prediction | More>> | ||||
| 1:1 ortholog | TBX22 | 100341565 | G1T5X7 | Oryctolagus cuniculus | Prediction | More>> | ||
| 1:1 ortholog | Tbx22 | 302369 | D3ZMK6 | Rattus norvegicus | Prediction | More>> |
| GO ID | GO Term |
|---|---|
| GO:0005634 | nucleus |
| GO:0003677 | DNA binding |
| GO:0001228 | DNA-binding transcription activator activity, RNA polymerase II-specific |
| GO:0001102 | RNA polymerase II activating transcription factor binding |
| GO:0000977 | RNA polymerase II regulatory region sequence-specific DNA binding |
| GO:0001708 | cell fate specification |
| GO:0000122 | negative regulation of transcription by RNA polymerase II |
| GO:0045892 | negative regulation of transcription, DNA-templated |
| GO:0045944 | positive regulation of transcription by RNA polymerase II |
| Pfam ID | Pfam Term |
|---|---|
| PF00907 | T-box |