| Tag | Content |
|---|---|
| Uniprot ID | G3N243 |
| Entrez ID | 100299988 |
| Genbank protein ID | |
| Genbank nucleotide ID | XM_002699958.2; XM_003585054.2; |
| Ensembl protein ID | ENSBTAP00000055948 |
| Ensembl nucleotide ID | ENSBTAG00000048060 |
| Gene name | T-box transcription factor 22 |
| Gene symbol | TBX22 |
| Organism | Bos taurus |
| NCBI taxa ID | 9913 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | |
| Sequence | MALSSRAHAF SVEALVGRPS KRKLQDPREE TQPELLEKEG GEEEDRRSSA AAGTKSEPPE 60 KRTKTDPLAT TFGFNSFGSL EEKDIIQVEL QGSELWKRFH DIGTEMIITK AGRRMFPSVR 120 VKVKGLDPGK QYYVAIDVVP VDSKRYRYIY HSSQWMIAGN TDHSCITPRV YIHPDSPCSG 180 ETWMRQIISF DRVKLTNNEM DDKGHIILQS MHKYKPRVHV MKQDSRVDMS RIQSLPAEGV 240 KTFSFKETEF TTVTAYQNQQ ITKLKIDRNP FAKGFRDPGR NRGVLDGLLE TYPWRPSLTL 300 DFKTFSADTQ SGSSSSSPVT SSGGAPSPLN SLLSPLCSPP TFHIPTSSLG MPRPEVYLHS 360 INLPLCYKIC PNNFWQQQPL VLSALESLAS NNSSQSSAPL MMEVPMLSSL GVTNSKNGSS 420 GDLNGQCLQA PKSSNQMYEL QALENILSPN PIAQEAIACS FHPSYGFYRY NFSTPPRLVN 480 AANRLKVNDN SQVSFIEGKY NHSHWYPKIS HCL 513 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | TBX22 | 100299988 | G3N243 | Bos taurus | Prediction | More>> | ||
| 1:1 ortholog | TBX22 | A0A452EVR5 | Capra hircus | Prediction | More>> | |||
| 1:1 ortholog | TBX22 | 50945 | Q9Y458 | CPO,CL/P | Homo sapiens | Publication | More>> | |
| 1:1 ortholog | Tbx22 | 245572 | Q8K402 | CPO | E11.5, E12.5, E14.0, E13.5, E14.5 | Mus musculus | Publication | More>> |
| 1:1 ortholog | TBX22 | 473683 | A0A2J8KJZ2 | Pan troglodytes | Prediction | More>> | ||
| 1:1 ortholog | A0A4X1W2E6 | Sus scrofa | Prediction | More>> | ||||
| 1:1 ortholog | TBX22 | 100341565 | G1T5X7 | Oryctolagus cuniculus | Prediction | More>> | ||
| 1:1 ortholog | Tbx22 | 302369 | D3ZMK6 | Rattus norvegicus | Prediction | More>> |
| GO ID | GO Term |
|---|---|
| GO:0005634 | nucleus |
| GO:0001228 | DNA-binding transcription activator activity, RNA polymerase II-specific |
| GO:0001102 | RNA polymerase II activating transcription factor binding |
| GO:0000977 | RNA polymerase II regulatory region sequence-specific DNA binding |
| GO:0001708 | cell fate specification |
| GO:0000122 | negative regulation of transcription by RNA polymerase II |
| GO:0045944 | positive regulation of transcription by RNA polymerase II |
| Pfam ID | Pfam Term |
|---|---|
| PF00907 | T-box |