| Tag | Content |
|---|---|
| Uniprot ID | D3ZN76 |
| Entrez ID | 100360302 |
| Genbank protein ID | |
| Genbank nucleotide ID | NM_001276417.1 |
| Ensembl protein ID | ENSRNOP00000060572 |
| Ensembl nucleotide ID | ENSRNOG00000019122 |
| Gene name | Protein transport protein sec16 |
| Gene symbol | Sec16a |
| Organism | Rattus norvegicus |
| NCBI taxa ID | 10116 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | Plays a role in the organization of the endoplasmic reticulum exit sites (ERES), also known as transitional endoplasmic reticulum (tER). Required for secretory cargo traffic from the endoplasmic reticulum to the Golgi apparatus. |
| Sequence | MQPPPQAVPS GVAGPPPAGN PRSSFWANSP YRKPANNNAP VAPITRPLQP VTDPFAFNRQ 60 TLQNTPVGSS SKSSPPNLPG PALPVFSQWP GLPVPPTNAG DSSTGLHEPL PGTLSQPRAD 120 PSLFPPASTP SSLPGLEVNR SAEVDSSSGP EVQMLPHPPH YIPGVGPEQP HGGHLNDSGA 180 GPDQSMNRHA PHDGAVAHAA SPFFPQPQMP GQWGPVHGGP PPSYHHHSPC LEGPVQDMGP 240 QAASLPHFPS PSSLHEGPGH ESRVPQTFTP ASLASGEGNE IVHQQSKNYP SSSFPPKHSF 300 EQNSRVGNMW ASAEFRQNPG VNKEHLLDPA HVNPFTQGNS PENQVHHPPV AATNHALQEA 360 ASGALSMFFQ GEETENEENL SSEKAGLDDR LDSGSFSSTS RLGHPPLPGA GGVYQAAQEG 420 DVQPYFSQFV GIRHDKQTTM TPANDAWGDI PGAGTHCASG PQCENVENLE FVQNQEVLPR 480 ETVNVDPFSP SDQFRYGPLP GPAASRPVTS GLTRGGGLNL EAPDMPLHPT RPDSVSSSYS 540 NHSHRSPPGS ARPQELVGTF IQQEVGKLED DTSGSFFKQI DSSPVGGETD EMTRSQNYCS 600 SLSQPSTPSP PKPTGVFQTS ANSSFEPVKS HLVGVKPVEA DRANMVVEVR GTQNCQKHGA 660 AVLPPDATPG NLEQPPDNME TLCAPQACPL PLSTTGEAGQ LVSHTAGPPL DTVRPMPDKR 720 SSARAQGPVK CESPATTLWA QNELPDFGGN VLLAPAAPAL YVPVKPKPSE VVHHPEKGMS 780 GQQSWKSGSV PPLQNQDPPG ASENLENPPK VGEEEALPLQ ASSGYASLLS SPPTESLHNQ 840 PVLIAQPDQS YNLAQPINFS VSLPNPNEKN QCWGDAVVGE KSMVSTRALG ADHEEHAALS 900 AIPASTVTGS SLPNSVTQNC APRGSGSSEM IASQPASWLV QQLSPQIPQS QHPNAEKGPS 960 EFVNSPANGS VMLAPPANSA VIPNSNKGYH SRNPEEAIGA LDFTLSRTLE NPVRMCSPSH 1020 SNSPASQQPL ANHPRQSGPG LHNQDHFYQQ VTKDAQDHRS LERGQSELVP PPPQNSPQQV 1080 PQAACPEPSN PESPPTQGQS EGLVQPSASP APVNTGQQPQ PPQSSSASVT STNSNQAAVR 1140 SEQPWLHPPP TTFGPAPQDL ASYYYYRPPY EAYQSPYPSP YPSDPGAASL YYQDIYGLYE 1200 PRYRPYDSSA SAYAENHRYS EPERPSSRAS HYSDQLTPRQ GYPEGYYNSK SGWSSHSDYY 1260 ANYYSGQYDY GDPGRWDRYY GSRFRDPRTW DRRYWYDSDH DPYRKDNYAY SDRPEKCDDH 1320 WRYDPRFTGS FDDDTELHRD PYGEEVDRRS IHSEHSARSL RSTHSLPSRR SSLSSHSHQS 1380 QIYRSHHVTG GSFEAPHAPG SFHGDYAYGT YASNFSGAHG FPEYSYPADT SWPAAEQVPS 1440 RPTSPEKFTV PHVCARFGPG GQLLKVIPNL PSEGQPALVE IHSLETLLQH TPEQEEMRSF 1500 PGPLGKDDTH KVDVINFAQN KATKCLQNES LIDKESASLL WNFIILLCRQ NGTVVGTDIA 1560 ELLLRDHRTV WLPGKSPNEA NLIDFTNEAV EQVEEEESGE AQLSFLTDSQ TVTSSVLEKE 1620 TERFRELLLY GRKKDALESA MKNGLWGHAL LLASKMDSRT HARVMTRFAN SLPINDPLQT 1680 VYQLMSGRMP AASTCCGDEK WGDWRPHLAM VLSNLNNNMD VESRTMATMG DTLASKGLLD 1740 AAHFCYLMAQ VGFGVYTKKT TKLVLIGSNH SLPFLKFATN EAIQRTEAYE YAQSLGAHTC 1800 SLPNFQVFKF IYLCRLAEMG LATQAFHYCE VIAKSVLTQP TAYSPVLISQ LIQMASQLRL 1860 FDPQLKEKPE EESFVEPAWL VQLQHVERQI QEGTVLWNQD GTEPQQCHIT SGSEVEQPDG 1920 PGLNQQAGPR ADNPLLMPST EPLVHSVQLL PTAPQTLPDG QPAHLARVPM FPVPMSRPPL 1980 ELSAAYGPPG SVLGFPESSR SDPAVLHPGQ ALPPATPGLQ ESGPPLQEAR SPDPEMVPQG 2040 SPVRHSPPEP REEEFGKNVA DLGSSRTAQD SETSPVWDLG SSSLTRAPSL TPDSEGKKPA 2100 QAVKKEPKEP KKTESWFSRW LPGKKRTEAY LPDDKNKSIV WDEKKNQWVN LNEPEEEKKA 2160 PPPPPTSFPR VPQAAPTGPA GPPMASVNVF SRKAGGSRAR YVDVLNPSGT QRSEPALAPA 2220 DFFAPLAPLP IPSNLFVPNP DAEESQPADG TGCRGQAPAG TQSKAEPTLE AKVVSSTVSA 2280 PGPELSPSKP ADGSQGGEAP GDHCPAGATP GGSVPFYNPA QLVQASVTSG TSRPGRIGQR 2340 KYAALN 2346 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | SEC16A | 519689 | F1N6K7 | Bos taurus | Prediction | More>> | ||
| 1:1 ortholog | SEC16A | 102172363 | A0A452FDB3 | Capra hircus | Prediction | More>> | ||
| 1:1 ortholog | SEC16A | 9919 | O15027 | Homo sapiens | Publication | More>> | ||
| 1:1 ortholog | Sec16a | 227648 | E9QAT4 | Mus musculus | Prediction | More>> | ||
| 1:1 ortholog | SEC16A | 464863 | A0A2I3RWX9 | Pan troglodytes | Prediction | More>> | ||
| 1:1 ortholog | Sec16a | 100360302 | D3ZN76 | Rattus norvegicus | Prediction | More>> |
| GO ID | GO Term |
|---|---|
| GO:0005829 | cytosol |
| GO:0070971 | endoplasmic reticulum exit site |
| GO:0005789 | endoplasmic reticulum membrane |
| GO:0012507 | ER to Golgi transport vesicle membrane |
| GO:0000139 | Golgi membrane |
| GO:0031090 | organelle membrane |
| GO:0048471 | perinuclear region of cytoplasm |
| GO:0048208 | COPII vesicle coating |
| GO:0007029 | endoplasmic reticulum organization |
| GO:0006888 | endoplasmic reticulum to Golgi vesicle-mediated transport |
| GO:0007030 | Golgi organization |
| GO:0043000 | Golgi to plasma membrane CFTR protein transport |
| GO:0070863 | positive regulation of protein exit from endoplasmic reticulum |
| GO:0032527 | protein exit from endoplasmic reticulum |
| GO:0070973 | protein localization to endoplasmic reticulum exit site |
| GO:0072659 | protein localization to plasma membrane |
| GO:0050821 | protein stabilization |
| GO:0034976 | response to endoplasmic reticulum stress |