| Tag | Content |
|---|---|
| Uniprot ID | F1N6K7 |
| Entrez ID | 519689 |
| Genbank protein ID | |
| Genbank nucleotide ID | XM_002691659.5; XM_597914.8; |
| Ensembl protein ID | ENSBTAP00000040372 |
| Ensembl nucleotide ID | ENSBTAG00000023933 |
| Gene name | Protein transport protein sec16 |
| Gene symbol | SEC16A |
| Organism | Bos taurus |
| NCBI taxa ID | 9913 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | Plays a role in the organization of the endoplasmic reticulum exit sites (ERES), also known as transitional endoplasmic reticulum (tER). Required for secretory cargo traffic from the endoplasmic reticulum to the Golgi apparatus. |
| Sequence | MQPPPQAVPS GVVGPPPSGS PQTMFWSNSP YRRQAGSHAP MAPVACPLQP VTDPFAFSRQ 60 ALQTTSLGGS SKSSLPILQG PALPSSLQRA GLPVPHTNTG DSSQGPCEPL PGPPVQPRAD 120 ASPFPGAPMP SASHGPETTR SAKAPGPEPE LPDPPYPPQY IPAAGSSGAR GGLPQGHASG 180 PDRPLSRPSP PDSATPPAAL PLPPQPCQQV PGQWGPGQGG PRPPGQHYWP GPEGPPQIPG 240 PHASSVTHFP PLSSLHQRPG HEQLGPPASL PGPSASGGKN EAAYLPSGDH SANSFDPESA 300 FRQNSRVGNA RANQELRSSP GVNREQLSGL AAISPLAQVN RPESRSHYLP GAGGGWTPLE 360 VGSGALAMFF KGGETENEEN LSLETAGSAG QADIDSFCLG QLPAHVGVGG AHQAFPRGSS 420 SEPMQLGGEP QPASKAAAMD VWADTARAGA QYENVENLEF VQNQEVLPSE PLTMDPSSPG 480 DPLRCGPLPG PAGPRLSAVG PAGSGGPNLE ALDMTAHPAR SDSVSSGYGG KSHRALPGAA 540 RPCDSGTFIQ QEVGKPEDES AGRFFKQIDS SPVGGETDET SSQNYHGSLS QPSTPSPPKP 600 TGVFQTSANS SFEPVKSHLV GVKPIEADRA NVVGEVRGPS AHQKQHRAAA ATPDATPGNL 660 EQPPDNMETL FPPQRCVPPL TTPVEAGRGL LQATGPPLET VLPAPEKRPS TRAQGPGTCE 720 SPATTLWAQN ELPDFGGNVL LAPAAPALHV PVKPQPSEVI QPPDEGVARQ VGPGCQSGDG 780 LGTSENLENP PQLGEEEVLP PQAGPGYASL LSSPPTECLQ NQPVLIAQPD QSYSLAQPVN 840 SSVSLPNSNE KAPSWRDSSV GDKPSVSGRA AGGDPGENVP LSGMPAGSLV CSPPPSHLAQ 900 SPFPQASGTY DMVSNQAANL LVQLHSHPKP SLPEGQKAHS AECVPPEGLP SPAGASGLVL 960 VPPAGGSSVP GSSKPGLCGR RDGAVGALDC TFSRTLENPA GVYGPAHADG PASGQQPTAS 1020 CRPLGPGANS PDRFYQQVMK EAQDQPGAER AKQELAPPLP APQGPRAVLL EPSTPGSPPV 1080 QAQPADPAQP ASPAPADAGQ QLPPRPPRSS SASVVSTSSS QAAPRPDQQW LQPPPPDLAS 1140 YYYYRSLYDG YQPPYPSPYP PDPGPAPHYY QDVYGLYDPR YRPSDGAAYV DPCRCPEPER 1200 PGSRASHCSD RPVARQVYPE GYYNSKSGWS SQSDYYAAYY SGQYDYGDPS RWDRFYYGPR 1260 FRDPRSYDRG YWCDAEYDLC RKENYAYGDR PEKYDDRYRY DPRFTGSFDD EPEPPRDPYG 1320 EEVDRRSEHS EHSARSLRSA PSLQSRRSSF SAHSHQSQVY RSHNVPSGSY EVPPPPGSFH 1380 GDYAYGPYGS DFHGAPGFPE YGYPAEASWP SVEQAPSRPT SPEKFSVPHV CARFGPGGQL 1440 IKVIPNLPSE GQPALVEIHS METLLQHTPE QEEMRAFPGP LGKDETHKVD VINFAQNKAT 1500 KCLQNENLID KESASLLWSF IVLLCRQNGT VVGTDIAELL LRDHRTVWLP GKSPNEANLI 1560 DFTNEAVEQA EEEESGEAQL SFLTDSQAAS TLEKDTERFR ELLLYGRKKD ALESAMKNGL 1620 WGHALLLASK MDSRTHARVM TRFANSLPIN DPLQTVYQLM SGRMPAASTC CGDEKWGDWR 1680 PHLAMILSNL SSSVDVESRA MATMGDTLAS KGLIDAAHFC YLMAQVGFGV YTKKTAKLVL 1740 IGSNHSLPFL KFATNEAIQR TEAYEYAQSL GAQACSPPSF QVFRFIYCCR LAEMGLAAQA 1800 FHYCEAIARS VLAQPHRHSP VLLRQLVQVA SQLRLFDPQL KEKPEEEASA EPPWLVQLQL 1860 VERQVEEGAV AWSQDGACPP HCPSSPSPEV GPRDGPEPTQ LVGLGADNPL LAPPVTGAEL 1920 LSQDVRLLPS APLTLPDGPA AIPVRVPMFP VPLPGPVELG PVHGPPGAVP GFPEPSGPDP 1980 VALYPGPGVP PLQETDRLLP EARGQDTGVV PQETPGRSSR SEPGEEEFGG NFADTGSFRT 2040 SPSPDTPPQA LQLPAPLTPA PEAQRPVQAA KKESKEPKKS SESWFSRWLP VKKRTEAYLP 2100 DDKNKSIVWD EKKNRWVDVN EPEEEKKAPP PPPAALPKAP QAAHPGPGGL PRPTVNMYSR 2160 KAAGTRARYV DVLNPGGPQR SEPAVAPTDL FAPLAPLPIP AHLLGPNADA EELPSTEGAS 2220 REGPARPEPT SDPKVFGPAV ASLPGPELPA SGLDGPQGGE LSRCSSLSSL SREVSQHFNQ 2280 APGALAPAGA PSGAAVPFYN PAQFAQAPAA SGSSRTGRIG QRKYPALS 2328 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | SEC16A | 519689 | F1N6K7 | Bos taurus | Prediction | More>> | ||
| 1:1 ortholog | SEC16A | 102172363 | A0A452FDB3 | Capra hircus | Prediction | More>> | ||
| 1:1 ortholog | SEC16A | 9919 | O15027 | Homo sapiens | Publication | More>> | ||
| 1:1 ortholog | Sec16a | 227648 | E9QAT4 | Mus musculus | Prediction | More>> | ||
| 1:1 ortholog | SEC16A | 464863 | A0A2I3RWX9 | Pan troglodytes | Prediction | More>> | ||
| 1:1 ortholog | Sec16a | 100360302 | D3ZN76 | Rattus norvegicus | Prediction | More>> |
| GO ID | GO Term |
|---|---|
| GO:0005829 | cytosol |
| GO:0070971 | endoplasmic reticulum exit site |
| GO:0005789 | endoplasmic reticulum membrane |
| GO:0012507 | ER to Golgi transport vesicle membrane |
| GO:0000139 | Golgi membrane |
| GO:0048471 | perinuclear region of cytoplasm |
| GO:0048208 | COPII vesicle coating |
| GO:0007029 | endoplasmic reticulum organization |
| GO:0007030 | Golgi organization |
| GO:0043000 | Golgi to plasma membrane CFTR protein transport |
| GO:0070863 | positive regulation of protein exit from endoplasmic reticulum |
| GO:0032527 | protein exit from endoplasmic reticulum |
| GO:0070973 | protein localization to endoplasmic reticulum exit site |
| GO:0050821 | protein stabilization |
| GO:0034976 | response to endoplasmic reticulum stress |