| Tag | Content |
|---|---|
| Uniprot ID | D4A1E5 |
| Entrez ID | 298555 |
| Genbank protein ID | EDL80760.1 |
| Genbank nucleotide ID | NM_001106690.1 |
| Ensembl protein ID | ENSRNOP00000061035 |
| Ensembl nucleotide ID | ENSRNOG00000029427 |
| Gene name | Grainyhead-like transcription factor 3 |
| Gene symbol | Grhl3 |
| Organism | Rattus norvegicus |
| NCBI taxa ID | 10116 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | |
| Sequence | MSNELDFRSV RLLKNDPVSF QKFPYNNEDE AWKTYLENPL TAATKAIMRV NGDDESVAAL 60 SFLYDYYMGP KEKRILSSST GGRNDQGKKY YHSMDYEPDL APLESPTHLM KFLTENVSGS 120 PDYTDQLKKN NLLGLEGALP TPGKTSTLPP GPSKLEAGSM DSYLLPTSDM YDNSSLNSLF 180 ESIHGVPPTH DFEYTLGSPK AIHIKAGESP MAYLNKGQFY PVTLRTPAGG KGLSLSSSKV 240 KSVVMIVFDN DKVPVEQLRF WRHWHSRQPT AKQRVIDVAD CKENFNTVQH IEEVAYNALS 300 FVWNVNEEAK VFIGVNCLST DFSSQKGVKG VPLNLQIDTY DCGAGTERLG AERKMRDDER 360 KQFRRKVKCP DSSNNGIKGC LLSGFRGNET TYLRPEADLE TQPVLFIPNL HFSSLQRPGG 420 VVPSAGHSSS DRLPLKRTCS PFAEEFEPLP SKQAKEDDLQ RVLLYVRRET EEVFDALMLK 480 TPDLKGLRNA ISEKYGFPEE NICKVYKKCK RGILVNMDNN IIQHYSNHVA FLLDMGELDG 540 KIQIILKEL 549 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | GRHL3 | 102178225 | A0A452F7N1 | Capra hircus | Prediction | More>> | ||
| 1:1 ortholog | GRHL3 | 57822 | Q8TE85 | Homo sapiens | Prediction | More>> | ||
| 1:1 ortholog | Grhl3 | 230824 | Q5FWH3 | CPO | Mus musculus | Publication | More>> | |
| 1:1 ortholog | GRHL3 | 456630 | H2RDV8 | Pan troglodytes | Prediction | More>> | ||
| 1:1 ortholog | GRHL3 | A0A287B8R5 | Sus scrofa | Prediction | More>> | |||
| 1:1 ortholog | GRHL3 | 100356381 | G1T595 | Oryctolagus cuniculus | Prediction | More>> | ||
| 1:1 ortholog | Grhl3 | 298555 | D4A1E5 | Rattus norvegicus | Prediction | More>> | ||
| 1:1 ortholog | grhl3 | E7F6C3 | Danio rerio | Prediction | More>> |
| GO ID | GO Term |
|---|---|
| GO:0005654 | nucleoplasm |
| GO:0005634 | nucleus |
| GO:0031490 | chromatin DNA binding |
| GO:0001228 | DNA-binding transcription activator activity, RNA polymerase II-specific |
| GO:0003700 | DNA-binding transcription factor activity |
| GO:0000981 | DNA-binding transcription factor activity, RNA polymerase II-specific |
| GO:0000978 | RNA polymerase II cis-regulatory region sequence-specific DNA binding |
| GO:0043565 | sequence-specific DNA binding |
| GO:0007417 | central nervous system development |
| GO:0090103 | cochlea morphogenesis |
| GO:0007398 | ectoderm development |
| GO:0008544 | epidermis development |
| GO:0001736 | establishment of planar polarity |
| GO:0061436 | establishment of skin barrier |
| GO:0061029 | eyelid development in camera-type eye |
| GO:0001843 | neural tube closure |
| GO:0007389 | pattern specification process |
| GO:0090179 | planar cell polarity pathway involved in neural tube closure |
| GO:0010628 | positive regulation of gene expression |
| GO:0043547 | positive regulation of GTPase activity |
| GO:0045944 | positive regulation of transcription by RNA polymerase II |
| GO:0045893 | positive regulation of transcription, DNA-templated |
| GO:0032956 | regulation of actin cytoskeleton organization |
| GO:0006357 | regulation of transcription by RNA polymerase II |
| GO:0042060 | wound healing |
| Keyword ID | Keyword Term |
|---|---|
| KW-1185 | Reference proteome |
| Pfam ID | Pfam Term |
|---|---|
| PF04516 | CP2 |