| Tag | Content |
|---|---|
| Uniprot ID | D4AA36 |
| Entrez ID | 304071 |
| Genbank protein ID | EDL76725.1 |
| Genbank nucleotide ID | NM_001107108.3 |
| Ensembl protein ID | ENSRNOP00000069809 |
| Ensembl nucleotide ID | ENSRNOG00000054203 |
| Gene name | SIM bHLH transcription factor 2 |
| Gene symbol | Sim2 |
| Organism | Rattus norvegicus |
| NCBI taxa ID | 10116 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | |
| Sequence | MKEKSKNAAK TRREKENGEF YELAKLLPLP SAITSQLDKA SIIRLTTSYL KMRAVFPEGL 60 GDAWGQPSRT GPLDSVAKEL GSHLLQTLDG FVFVVASDGK IMYISETASV HLGLSQVELT 120 GNSIYEYIHP SDHDEMTAVL TAHPPLHHHL LQEYEIERSF FLRMKCVLAK RNAGLTCSGY 180 KVIHCSGYLK IRQYMLDMSL YDSCYQIVGL VAVGQSLPPS AITEIKLHNN MFMFRASLDL 240 KLIFLDSRVT ELTGYEPQDL IEKTLYHHVH GCDTFHLRYA HHLLLVKGQV TTKYYRLLSK 300 LGGWVWVQSY ATVVHNSRSS RPHCIVSVNY VLTEVEYKEL QLSLDQVSTS KSQESWRTTL 360 STSQETRKSA KPKTTKMRTK LRTNPYPSQQ YSSFQMDKLE CSQAGNWRTS PPTSAVAPPE 420 QQLHSEASDL LYGPPYSLPF SYRYGHFPLD SHVFSSKKPG LPAKFGQPQG SPCEVARFFL 480 STLPASSECQ WHYANSLMPS SPSPAKNLSE SPVNAARHGL VPNYEAPAAT ARRFGEDPAP 540 SSFPSCGHYR EEPTLGSAKA ARQASRDTAR LALARATPEC CAPPAPEPQA PAQLPFVLLN 600 YHRVLARRGP LGSAAPGAPE AAGSLRPRHP GPVAASAPGA PRPHYLGASV IITNGR 656 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | SIM2 | A0A5F4C0N9 | Canis lupus familiaris | Prediction | More>> | |||
| 1:1 ortholog | SIM2 | 102179422 | A0A452FXM0 | Capra hircus | Prediction | More>> | ||
| 1:1 ortholog | SIM2 | 6493 | Q14190 | Homo sapiens | Prediction | More>> | ||
| 1:1 ortholog | Sim2 | 20465 | Q61079 | CPO | E14.5 | Mus musculus | Publication | More>> |
| 1:1 ortholog | SIM2 | 474107 | A0A2I3TNB0 | Pan troglodytes | Prediction | More>> | ||
| 1:1 ortholog | SIM2 | I3LA51 | Sus scrofa | Prediction | More>> | |||
| 1:1 ortholog | Sim2 | 304071 | D4AA36 | Rattus norvegicus | Prediction | More>> |
| GO ID | GO Term |
|---|---|
| GO:0016604 | nuclear body |
| GO:0005634 | nucleus |
| GO:0003677 | DNA binding |
| GO:0000981 | DNA-binding transcription factor activity, RNA polymerase II-specific |
| GO:0046982 | protein heterodimerization activity |
| GO:0009880 | embryonic pattern specification |
| GO:0030324 | lung development |
| GO:0000122 | negative regulation of transcription by RNA polymerase II |
| GO:0045892 | negative regulation of transcription, DNA-templated |
| GO:0045944 | positive regulation of transcription by RNA polymerase II |
| GO:0006357 | regulation of transcription by RNA polymerase II |