| Tag | Content |
|---|---|
| Uniprot ID | I3LA51 |
| Entrez ID | |
| Genbank protein ID | HCZ75107.1 |
| Genbank nucleotide ID | |
| Ensembl protein ID | ENSSSCP00000020917 |
| Ensembl nucleotide ID | ENSSSCG00000027179 |
| Gene name | SIM bHLH transcription factor 2 |
| Gene symbol | SIM2 |
| Organism | Sus scrofa |
| NCBI taxa ID | 9823 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | |
| Sequence | MKEKSKNAAK TRREKENGEF YELAKLLPLP SAITSQLDKA SIIRLTTSYL KMRAVFPEGL 60 GDAWGQPSRA GPLDSVAKEL GSHLLQTLDG FVFVVASDGK IMYISETASV HLGLSQVELT 120 GNSIYEYIHP SDHDEMTAVL AAHQPLHHHL LQEYEIERSF FLRMKCVLAK RNAGLTCSGY 180 KVIHCSGYLK IRQYMLDMSL YDSCYQIVGL VAVGQSLPPS AITEIKLHSN MFMFRASLDL 240 KLIFLDSRVT ELTGYEPQDL IEKTLYHHVH GCDVFHLRYA HHLLLVKGQV TTKYYRLLSK 300 LGGWVWVQSC ATVVHNSRSS RPHCIVSVNY VLTDIEYKEL QLSLDQVSTS KSQDSWRTAL 360 STSQETRKLA KPKNTKMKTK LRTNPYPPQQ YSSFQMDKLD CGQLGSWRAS PPASAPAPPE 420 QQLHSEGGDL LYAPSYSLPF SYHYGHFPLD SHVFSSKKPM LPAKFGQPPG SPCEVARFLL 480 STLPAGSECQ WHYANPLVPS GPSPAKSLSQ PPANTARHSL GPNYEAPAAA ARRFGEDTAP 540 PPPSFPSCGH YREEPALGPA KAARQAARDG ARLALTGPAP ECCAPPAPEP PGAPAQLPFV 600 LLNYHRVLAR RGPLGGAAPA APALACGPGV PEAAAGALRP RPPGPAAAAA AASPPGAPLP 660 HYLGASVIIT NGR 673 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | SIM2 | A0A5F4C0N9 | Canis lupus familiaris | Prediction | More>> | |||
| 1:1 ortholog | SIM2 | 102179422 | A0A452FXM0 | Capra hircus | Prediction | More>> | ||
| 1:1 ortholog | SIM2 | 6493 | Q14190 | Homo sapiens | Prediction | More>> | ||
| 1:1 ortholog | Sim2 | 20465 | Q61079 | CPO | E14.5 | Mus musculus | Publication | More>> |
| 1:1 ortholog | SIM2 | 474107 | A0A2I3TNB0 | Pan troglodytes | Prediction | More>> | ||
| 1:1 ortholog | SIM2 | I3LA51 | Sus scrofa | Prediction | More>> | |||
| 1:1 ortholog | Sim2 | 304071 | D4AA36 | Rattus norvegicus | Prediction | More>> |
| GO ID | GO Term |
|---|---|
| GO:0016604 | nuclear body |
| GO:0005634 | nucleus |
| GO:0003677 | DNA binding |
| GO:0000981 | DNA-binding transcription factor activity, RNA polymerase II-specific |
| GO:0046982 | protein heterodimerization activity |
| GO:0009880 | embryonic pattern specification |
| GO:0030324 | lung development |
| GO:0000122 | negative regulation of transcription by RNA polymerase II |
| GO:0045944 | positive regulation of transcription by RNA polymerase II |
| GO:0006357 | regulation of transcription by RNA polymerase II |