| Tag | Content |
|---|---|
| Uniprot ID | Q61079; O35391; Q61046; Q61904; |
| Entrez ID | 20465 |
| Genbank protein ID | BAA09700.1; AAA91202.1; BAA11013.1; AAB84099.1; AAB19098.1; |
| Genbank nucleotide ID | NM_011377.2 |
| Ensembl protein ID | ENSMUSP00000072043 |
| Ensembl nucleotide ID | ENSMUSG00000062713 |
| Gene name | Single-minded homolog 2 |
| Gene symbol | Sim2 |
| Organism | Mus musculus |
| NCBI taxa ID | 10090 |
| Cleft type | CPO |
| Developmental stage | E14.5 |
| Data sources | Manually collected |
| Reference | 12203729 |
| Functional description | Transcription factor that may be a master gene of CNS development in cooperation with Arnt. It may have pleiotropic effects in the tissues expressed during development. |
| Sequence | MKEKSKNAAK TRREKENGEF YELAKLLPLP SAITSQLDKA SIIRLTTSYL KMRAVFPEGL 60 GDAWGQPSRT GPLDSVAKEL GSHLLQTLDG FVFVVASDGK IMYISETASV HLGLSQVELT 120 GNSIYEYIHP SDHDEMTAVL TAHPPLHHHL LQEYEIERSF FLRMKCVLAK RNAGLTCSGY 180 KVIHCSGYLK IRQYMLDMSL YDSCYQIVGL VAVGQSLPPS AITEIKLHSN MFMFRASLDL 240 KLIFLDSRVT ELTGYEPQDL IEKTLYHHVH GCDTFHLRYA HHLLLVKGQV TTKYYRLLSK 300 LGGWVWVQSY ATVVHNSRSS RPHCIVSVNY VLTDVEYKEL QLSLDQVSTS KSQESWRTTL 360 STSQETRKSA KPKNTKMKTK LRTNPYPPQQ YSSFQMDKLE CSQVGNWRTS PPTNAVAPPE 420 QQLHSEASDL LYGPPYSLPF SYHYGHFPLD SHVFSSKKPG LPAKFGQPQG SPCEVARFFL 480 STLPASSECQ WHCANSLVPS SSSPAKNLSE PSPVNAARHG LVPNYEAPSA AARRFCEDPA 540 PPSFPSCGHY REEPALGPAK APRQASRDAA RLALARAPPE CCAPPAPEPQ APAQLPFVLL 600 NYHRVLARRG PLGSAAPGAP EAAGSLRPRH PGPVAASAPG APRPHYLGAS VIITNGR 657 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | SIM2 | A0A5F4C0N9 | Canis lupus familiaris | Prediction | More>> | |||
| 1:1 ortholog | SIM2 | 102179422 | A0A452FXM0 | Capra hircus | Prediction | More>> | ||
| 1:1 ortholog | SIM2 | 6493 | Q14190 | Homo sapiens | Prediction | More>> | ||
| 1:1 ortholog | Sim2 | 20465 | Q61079 | CPO | E14.5 | Mus musculus | Publication | More>> |
| 1:1 ortholog | SIM2 | 474107 | A0A2I3TNB0 | Pan troglodytes | Prediction | More>> | ||
| 1:1 ortholog | SIM2 | I3LA51 | Sus scrofa | Prediction | More>> | |||
| 1:1 ortholog | Sim2 | 304071 | D4AA36 | Rattus norvegicus | Prediction | More>> |
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0000981 | DNA-binding transcription factor activity, RNA polymerase II-specific | IBA |
| GO:0003677 | DNA binding | IDA |
| GO:0005515 | protein binding | IPI |
| GO:0046982 | protein heterodimerization activity | IPI |
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0000122 | negative regulation of transcription by RNA polymerase II | IGI |
| GO:0006357 | regulation of transcription by RNA polymerase II | IBA |
| GO:0007399 | nervous system development | IEA |
| GO:0009880 | embryonic pattern specification | IMP |
| GO:0030154 | cell differentiation | IEA |
| GO:0030324 | lung development | IMP |
| GO:0045892 | negative regulation of transcription, DNA-templated | IDA |
| GO:0045944 | positive regulation of transcription by RNA polymerase II | IBA |
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0005634 | nucleus | IDA |
| GO:0005634 | nucleus | IBA |
| GO:0005654 | nucleoplasm | ISO |
| GO:0016604 | nuclear body | ISO |
| Reactome ID | Reactome Term | Evidence |
|---|