Gene: BMP7

Basic information

Tag Content
Uniprot ID E0A9E2
Entrez ID 100050299
Genbank protein ID ADK93983.1
Genbank nucleotide ID NM_001195158.1
Ensembl protein ID ENSECAP00000003311
Ensembl nucleotide ID ENSECAG00000002918
Gene name Bone morphogenetic protein 7
Gene symbol BMP7
Organism Equus caballus
NCBI taxa ID 9796
Cleft type
Developmental stage
Data sources Homology search
Reference
Functional description
Sequence
MHVRSLRTAA PHSFVALWAP LFLLRSALAD FSLDNEVHSS FIHRRLRSQE RREMQREILS 60
ILGLPHRPRP HLQGKHNSAP MFMLDLYNAM AVEESGGPDG QGFSYPHKAV SSTQGPPLAS 120
LQDSHFLTDA DMVMSFVNLV EHDKEFFHPR YHHREFRFDL SKIPEGEAVT AAEFRIYKDY 180
VRERFDNETF RISVYQVLQE HLARESDLFL LDSRTLWASE EGWLVFDITA TSNHWVVNPR 240
HNLGLQLSVE TLDGQSVNPK LAGLIGRHGP QTKQPFMVAF FKATEVHLRS TRSTGGKQRS 300
QNRSKTPKNQ EALRVANVAE NSSSDQRQAC KKHELYVSFR DLGWQDWIIA PEGYAAYYCE 360
GECAFPLNSY MNATNHAIVQ TLVHFINPET VPKPCCAPTQ LNAISVLYFD DSSNVILKKY 420
RNMVVRACGC H 431

Abbreviation :
CLO : cleft lip only. CPO : cleft palate only. CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.

Protein disorder information

Orthologous information

Relation Gene symbol Entrez ID UniProt ID Cleft type Developmental stage Species Evidence Details
1:1 orthologBMP7540595F1MLT0Bos taurusPredictionMore>>
1:1 orthologBMP7102177903A0A452E223Capra hircusPredictionMore>>
1:1 orthologBMP7100050299E0A9E2Equus caballusPredictionMore>>
1:1 orthologBMP7655P18075Homo sapiensPredictionMore>>
1:1 orthologBmp712162P23359CPOMus musculusPublicationMore>>
1:1 orthologBMP7458357H2QKM7Pan troglodytesPredictionMore>>
1:1 orthologBMP7492315A5GFN2Sus scrofaPredictionMore>>
1:1 orthologBmp785272G3V6W8Rattus norvegicusPredictionMore>>
1:1 orthologbmp7b557567F1QD07Danio rerioPredictionMore>>

Gene ontology

GO ID GO Term
GO:0005615 extracellular space
GO:0070700 BMP receptor binding
GO:0005125 cytokine activity
GO:0008083 growth factor activity
GO:0030509 BMP signaling pathway
GO:0010862 positive regulation of pathway-restricted SMAD protein phosphorylation
GO:0060395 SMAD protein signal transduction

Functional annotations

Keywords

Keyword ID Keyword Term
KW-1015 Disulfide bond
KW-0339 Growth factor
KW-1185 Reference proteome
KW-0964 Secreted
KW-0732 Signal

Interpro

InterPro ID InterPro Term
IPR029034 Cystine-knot_cytokine
IPR001839 TGF-b_C
IPR001111 TGF-b_propeptide
IPR015615 TGF-beta-rel
IPR017948 TGFb_CS

PROSITE

PROSITE ID PROSITE Term
PS00250 TGF_BETA_1
PS51362 TGF_BETA_2

Pfam

Pfam ID Pfam Term
PF00019 TGF_beta
PF00688 TGFb_propeptide