| Tag | Content |
|---|---|
| Uniprot ID | G3V6W8 |
| Entrez ID | 85272 |
| Genbank protein ID | EDL85136.1 |
| Genbank nucleotide ID | NM_001191856.2 |
| Ensembl protein ID | ENSRNOP00000070891 |
| Ensembl nucleotide ID | ENSRNOG00000053384 |
| Gene name | Bone morphogenetic protein 7 |
| Gene symbol | Bmp7 |
| Organism | Rattus norvegicus |
| NCBI taxa ID | 10116 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | |
| Sequence | MHVRSLRAAA PHSFVALWAP LFLLRSALAD FSLDNEVHSS FIHRRLRSQE RREMQREILS 60 ILGLPHRPRP HLQGKHNSAP MFMLDLYNAM AVEESGPDGQ GFSYPYKAVF STQGPPLASL 120 QDSHFLTDAD MVMSFVNLVE HDKEFFHPRY HHREFRFDLS KIPEGEAVTA AEFRIYKDYI 180 RERFDNETFQ ITVYQVLQEH SGRESDLFLL DSRTIWASEE GWLVFDITAT SNHWVVNPRH 240 NLGLQLSVET LDGQSINPKL AGLIGRHGPQ NKQPFMVAFF KATEVHLRSI RSTGGKQRSQ 300 NRSKTPKNQE ALRMASVAEN SSSDQRQACK KHELYVSFRD LGWQDWIIAP EGYAAYYCEG 360 ECAFPLNSYM NATNHAIVQT LVHFINPDTV PKPCCAPTQL NAISVLYFDD SSNVILKKYR 420 NMVVRACGCH |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | BMP7 | 540595 | F1MLT0 | Bos taurus | Prediction | More>> | ||
| 1:1 ortholog | BMP7 | 102177903 | A0A452E223 | Capra hircus | Prediction | More>> | ||
| 1:1 ortholog | BMP7 | 100050299 | E0A9E2 | Equus caballus | Prediction | More>> | ||
| 1:1 ortholog | BMP7 | 655 | P18075 | Homo sapiens | Prediction | More>> | ||
| 1:1 ortholog | Bmp7 | 12162 | P23359 | CPO | Mus musculus | Publication | More>> | |
| 1:1 ortholog | BMP7 | 458357 | H2QKM7 | Pan troglodytes | Prediction | More>> | ||
| 1:1 ortholog | BMP7 | 492315 | A5GFN2 | Sus scrofa | Prediction | More>> | ||
| 1:1 ortholog | Bmp7 | 85272 | G3V6W8 | Rattus norvegicus | Prediction | More>> | ||
| 1:1 ortholog | bmp7b | 557567 | F1QD07 | Danio rerio | Prediction | More>> |
| GO ID | GO Term |
|---|---|
| GO:0062023 | collagen-containing extracellular matrix |
| GO:0005615 | extracellular space |
| GO:0031982 | vesicle |
| GO:0070700 | BMP receptor binding |
| GO:0005125 | cytokine activity |
| GO:0008083 | growth factor activity |
| GO:0008201 | heparin binding |
| GO:1905069 | allantois development |
| GO:0048646 | anatomical structure formation involved in morphogenesis |
| GO:0009887 | animal organ morphogenesis |
| GO:0007411 | axon guidance |
| GO:0030509 | BMP signaling pathway |
| GO:0060445 | branching involved in salivary gland morphogenesis |
| GO:0048754 | branching morphogenesis of an epithelial tube |
| GO:0048593 | camera-type eye morphogenesis |
| GO:0048738 | cardiac muscle tissue development |
| GO:0060411 | cardiac septum morphogenesis |
| GO:0048468 | cell development |
| GO:0071773 | cellular response to BMP stimulus |
| GO:0060710 | chorio-allantoic fusion |
| GO:0048596 | embryonic camera-type eye morphogenesis |
| GO:0030326 | embryonic limb morphogenesis |
| GO:0009880 | embryonic pattern specification |
| GO:0060272 | embryonic skeletal joint morphogenesis |
| GO:0003272 | endocardial cushion formation |
| GO:0030855 | epithelial cell differentiation |
| GO:0001654 | eye development |
| GO:0061384 | heart trabecula morphogenesis |
| GO:0030902 | hindbrain development |
| GO:0001822 | kidney development |
| GO:0048762 | mesenchymal cell differentiation |
| GO:0060485 | mesenchyme development |
| GO:0001707 | mesoderm formation |
| GO:0001823 | mesonephros development |
| GO:0072136 | metanephric mesenchymal cell proliferation involved in metanephros development |
| GO:0072133 | metanephric mesenchyme morphogenesis |
| GO:0001656 | metanephros development |
| GO:0070487 | monocyte aggregation |
| GO:0045786 | negative regulation of cell cycle |
| GO:0060548 | negative regulation of cell death |
| GO:0008285 | negative regulation of cell population proliferation |
| GO:0072125 | negative regulation of glomerular mesangial cell proliferation |
| GO:0043407 | negative regulation of MAP kinase activity |
| GO:0072040 | negative regulation of mesenchymal cell apoptotic process involved in nephron morphogenesis |
| GO:0045839 | negative regulation of mitotic nuclear division |
| GO:0050768 | negative regulation of neurogenesis |
| GO:0045665 | negative regulation of neuron differentiation |
| GO:0045746 | negative regulation of Notch signaling pathway |
| GO:0042326 | negative regulation of phosphorylation |
| GO:0060686 | negative regulation of prostatic bud formation |
| GO:0045892 | negative regulation of transcription, DNA-templated |
| GO:0072134 | nephrogenic mesenchyme morphogenesis |
| GO:0021502 | neural fold elevation formation |
| GO:0048812 | neuron projection morphogenesis |
| GO:0042475 | odontogenesis of dentin-containing tooth |
| GO:0007389 | pattern specification process |
| GO:0003344 | pericardium morphogenesis |
| GO:0060037 | pharyngeal system development |
| GO:0043065 | positive regulation of apoptotic process |
| GO:0030501 | positive regulation of bone mineralization |
| GO:0090336 | positive regulation of brown fat cell differentiation |
| GO:1905312 | positive regulation of cardiac neural crest cell migration involved in outflow tract morphogenesis |
| GO:0010942 | positive regulation of cell death |
| GO:0045597 | positive regulation of cell differentiation |
| GO:1900006 | positive regulation of dendrite development |
| GO:0010718 | positive regulation of epithelial to mesenchymal transition |
| GO:0010628 | positive regulation of gene expression |
| GO:0034116 | positive regulation of heterotypic cell-cell adhesion |
| GO:1900106 | positive regulation of hyaluranon cable assembly |
| GO:0045666 | positive regulation of neuron differentiation |
| GO:0045669 | positive regulation of osteoblast differentiation |
| GO:0010862 | positive regulation of pathway-restricted SMAD protein phosphorylation |
| GO:0010800 | positive regulation of peptidyl-threonine phosphorylation |
| GO:0045944 | positive regulation of transcription by RNA polymerase II |
| GO:0045893 | positive regulation of transcription, DNA-templated |
| GO:0034504 | protein localization to nucleus |
| GO:0060687 | regulation of branching involved in prostate gland morphogenesis |
| GO:0060393 | regulation of pathway-restricted SMAD protein phosphorylation |
| GO:0042325 | regulation of phosphorylation |
| GO:0032355 | response to estradiol |
| GO:0043434 | response to peptide hormone |
| GO:0033280 | response to vitamin D |
| GO:0007435 | salivary gland morphogenesis |
| GO:0060395 | SMAD protein signal transduction |
| GO:0043401 | steroid hormone mediated signaling pathway |
| GO:0035239 | tube morphogenesis |
| GO:0001657 | ureteric bud development |