| Tag | Content |
|---|---|
| Uniprot ID | P23359; Q91XF7; |
| Entrez ID | 12162 |
| Genbank protein ID | CAA40222.1; AAH10771.1; |
| Genbank nucleotide ID | NM_007557.3 |
| Ensembl protein ID | ENSMUSP00000009143 |
| Ensembl nucleotide ID | ENSMUSG00000008999 |
| Gene name | Bone morphogenetic protein 7 |
| Gene symbol | Bmp7 |
| Organism | Mus musculus |
| NCBI taxa ID | 10090 |
| Cleft type | CPO |
| Developmental stage | |
| Data sources | Manually collected |
| Reference | 19127565; 23091646; 23516636; 22219353; |
| Functional description | Induces cartilage and bone formation. May be the osteoinductive factor responsible for the phenomenon of epithelial osteogenesis. Plays a role in calcium regulation and bone homeostasis. Promotes brown adipocyte differentiation by P38 MAPK pathway-mediated activation of target genes, including members of the SOX family of transcription factors (By similarity). |
| Sequence | MHVRSLRAAA PHSFVALWAP LFLLRSALAD FSLDNEVHSS FIHRRLRSQE RREMQREILS 60 ILGLPHRPRP HLQGKHNSAP MFMLDLYNAM AVEESGPDGQ GFSYPYKAVF STQGPPLASL 120 QDSHFLTDAD MVMSFVNLVE HDKEFFHPRY HHREFRFDLS KIPEGEAVTA AEFRIYKDYI 180 RERFDNETFQ ITVYQVLQEH SGRESDLFLL DSRTIWASEE GWLVFDITAT SNHWVVNPRH 240 NLGLQLSVET LDGQSINPKL AGLIGRHGPQ NKQPFMVAFF KATEVHLRSI RSTGGKQRSQ 300 NRSKTPKNQE ALRMASVAEN SSSDQRQACK KHELYVSFRD LGWQDWIIAP EGYAAYYCEG 360 ECAFPLNSYM NATNHAIVQT LVHFINPDTV PKPCCAPTQL NAISVLYFDD SSNVILKKYR 420 NMVVRACGCH |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | BMP7 | 540595 | F1MLT0 | Bos taurus | Prediction | More>> | ||
| 1:1 ortholog | BMP7 | 102177903 | A0A452E223 | Capra hircus | Prediction | More>> | ||
| 1:1 ortholog | BMP7 | 100050299 | E0A9E2 | Equus caballus | Prediction | More>> | ||
| 1:1 ortholog | BMP7 | 655 | P18075 | Homo sapiens | Prediction | More>> | ||
| 1:1 ortholog | Bmp7 | 12162 | P23359 | CPO | Mus musculus | Publication | More>> | |
| 1:1 ortholog | BMP7 | 458357 | H2QKM7 | Pan troglodytes | Prediction | More>> | ||
| 1:1 ortholog | BMP7 | 492315 | A5GFN2 | Sus scrofa | Prediction | More>> | ||
| 1:1 ortholog | Bmp7 | 85272 | G3V6W8 | Rattus norvegicus | Prediction | More>> | ||
| 1:1 ortholog | bmp7b | 557567 | F1QD07 | Danio rerio | Prediction | More>> |
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0005125 | cytokine activity | IBA |
| GO:0005125 | cytokine activity | TAS |
| GO:0005515 | protein binding | IPI |
| GO:0008083 | growth factor activity | IEA |
| GO:0008201 | heparin binding | ISO |
| GO:0070700 | BMP receptor binding | IBA |
| GO:0070700 | BMP receptor binding | ISO |
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0001503 | ossification | IEA |
| GO:0001654 | eye development | IMP |
| GO:0001657 | ureteric bud development | IMP |
| GO:0001707 | mesoderm formation | IGI |
| GO:0001822 | kidney development | IMP |
| GO:0003272 | endocardial cushion formation | IGI |
| GO:0003344 | pericardium morphogenesis | IGI |
| GO:0007389 | pattern specification process | IMP |
| GO:0007411 | axon guidance | IDA |
| GO:0007435 | salivary gland morphogenesis | IMP |
| GO:0008285 | negative regulation of cell population proliferation | IMP |
| GO:0009880 | embryonic pattern specification | IMP |
| GO:0009887 | animal organ morphogenesis | IMP |
| GO:0010628 | positive regulation of gene expression | ISO |
| GO:0010718 | positive regulation of epithelial to mesenchymal transition | IGI |
| GO:0010800 | positive regulation of peptidyl-threonine phosphorylation | ISO |
| GO:0010862 | positive regulation of pathway-restricted SMAD protein phosphorylation | ISS |
| GO:0010862 | positive regulation of pathway-restricted SMAD protein phosphorylation | ISO |
| GO:0010862 | positive regulation of pathway-restricted SMAD protein phosphorylation | IBA |
| GO:0010942 | positive regulation of cell death | IGI |
| GO:0021502 | neural fold elevation formation | IGI |
| GO:0030326 | embryonic limb morphogenesis | IGI |
| GO:0030326 | embryonic limb morphogenesis | IMP |
| GO:0030501 | positive regulation of bone mineralization | ISO |
| GO:0030509 | BMP signaling pathway | ISO |
| GO:0030509 | BMP signaling pathway | IDA |
| GO:0030509 | BMP signaling pathway | IBA |
| GO:0030855 | epithelial cell differentiation | IMP |
| GO:0030902 | hindbrain development | IGI |
| GO:0032355 | response to estradiol | IEA |
| GO:0033280 | response to vitamin D | IEA |
| GO:0034116 | positive regulation of heterotypic cell-cell adhesion | ISO |
| GO:0034504 | protein localization to nucleus | ISS |
| GO:0034504 | protein localization to nucleus | ISO |
| GO:0035239 | tube morphogenesis | IDA |
| GO:0042325 | regulation of phosphorylation | ISO |
| GO:0042326 | negative regulation of phosphorylation | ISS |
| GO:0042326 | negative regulation of phosphorylation | ISO |
| GO:0042475 | odontogenesis of dentin-containing tooth | IDA |
| GO:0043065 | positive regulation of apoptotic process | IMP |
| GO:0043401 | steroid hormone mediated signaling pathway | ISO |
| GO:0043407 | negative regulation of MAP kinase activity | ISS |
| GO:0043407 | negative regulation of MAP kinase activity | ISO |
| GO:0043434 | response to peptide hormone | IEA |
| GO:0045597 | positive regulation of cell differentiation | IDA |
| GO:0045665 | negative regulation of neuron differentiation | IMP |
| GO:0045665 | negative regulation of neuron differentiation | ISO |
| GO:0045666 | positive regulation of neuron differentiation | IDA |
| GO:0045669 | positive regulation of osteoblast differentiation | ISO |
| GO:0045746 | negative regulation of Notch signaling pathway | IGI |
| GO:0045786 | negative regulation of cell cycle | ISO |
| GO:0045839 | negative regulation of mitotic nuclear division | ISS |
| GO:0045839 | negative regulation of mitotic nuclear division | ISO |
| GO:0045892 | negative regulation of transcription, DNA-templated | ISS |
| GO:0045892 | negative regulation of transcription, DNA-templated | ISO |
| GO:0045893 | positive regulation of transcription, DNA-templated | ISO |
| GO:0045944 | positive regulation of transcription by RNA polymerase II | IGI |
| GO:0048468 | cell development | IDA |
| GO:0048593 | camera-type eye morphogenesis | IMP |
| GO:0048596 | embryonic camera-type eye morphogenesis | IMP |
| GO:0048646 | anatomical structure formation involved in morphogenesis | IMP |
| GO:0048738 | cardiac muscle tissue development | IGI |
| GO:0048754 | branching morphogenesis of an epithelial tube | IDA |
| GO:0048762 | mesenchymal cell differentiation | ISS |
| GO:0048762 | mesenchymal cell differentiation | ISO |
| GO:0048812 | neuron projection morphogenesis | IMP |
| GO:0048812 | neuron projection morphogenesis | ISO |
| GO:0050768 | negative regulation of neurogenesis | IDA |
| GO:0051216 | cartilage development | IEA |
| GO:0060037 | pharyngeal system development | IGI |
| GO:0060272 | embryonic skeletal joint morphogenesis | IGI |
| GO:0060272 | embryonic skeletal joint morphogenesis | IMP |
| GO:0060393 | regulation of pathway-restricted SMAD protein phosphorylation | ISO |
| GO:0060395 | SMAD protein signal transduction | ISS |
| GO:0060395 | SMAD protein signal transduction | ISO |
| GO:0060395 | SMAD protein signal transduction | IBA |
| GO:0060411 | cardiac septum morphogenesis | IGI |
| GO:0060445 | branching involved in salivary gland morphogenesis | IMP |
| GO:0060485 | mesenchyme development | IMP |
| GO:0060548 | negative regulation of cell death | ISO |
| GO:0060686 | negative regulation of prostatic bud formation | IDA |
| GO:0060687 | regulation of branching involved in prostate gland morphogenesis | IMP |
| GO:0060710 | chorio-allantoic fusion | IGI |
| GO:0061384 | heart trabecula morphogenesis | IGI |
| GO:0070487 | monocyte aggregation | ISO |
| GO:0071773 | cellular response to BMP stimulus | ISO |
| GO:0072040 | negative regulation of mesenchymal cell apoptotic process involved in nephron morphogenesis | IMP |
| GO:0072125 | negative regulation of glomerular mesangial cell proliferation | ISS |
| GO:0072125 | negative regulation of glomerular mesangial cell proliferation | ISO |
| GO:0072133 | metanephric mesenchyme morphogenesis | IGI |
| GO:0072134 | nephrogenic mesenchyme morphogenesis | IGI |
| GO:0072136 | metanephric mesenchymal cell proliferation involved in metanephros development | IGI |
| GO:1900006 | positive regulation of dendrite development | ISO |
| GO:1900106 | positive regulation of hyaluranon cable assembly | ISO |
| GO:1905069 | allantois development | IGI |
| GO:1905312 | positive regulation of cardiac neural crest cell migration involved in outflow tract morphogenesis | IGI |
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0005615 | extracellular space | ISO |
| GO:0005615 | extracellular space | IDA |
| GO:0005615 | extracellular space | IBA |
| GO:0031982 | vesicle | ISO |
| GO:0062023 | collagen-containing extracellular matrix | ISO |
| Reactome ID | Reactome Term | Evidence |
|---|---|---|
| R-MMU-1474244 | Extracellular matrix organization | IEA |
| R-MMU-1566948 | Elastic fibre formation | IEA |
| R-MMU-2129379 | Molecules associated with elastic fibres | IEA |