Gene: IFT172

Basic information

Tag Content
Uniprot ID E2RF25
Entrez ID 483013
Genbank protein ID
Genbank nucleotide ID XM_540128.5
Ensembl protein ID ENSCAFP00000007617
Ensembl nucleotide ID ENSCAFG00000005048
Gene name Intraflagellar transport 172
Gene symbol IFT172
Organism Canis lupus familiaris
NCBI taxa ID 9615
Cleft type
Developmental stage
Data sources Homology search
Reference
Functional description
Sequence
MQLKHLRTLL SPQDGAAKVT CMAWSHNNAK FAVCTVDRVV LLYDEHGERR DKFSTKPADM 60
KYGRKSYMVK GMAFSPDSTK IAIGQTDNII YVYKIGEDWG DKKVICNKFI QTSAVTCLQW 120
PAEHIIVFGL AEGKVRLANT KTNKSSTIYG TDSYVVSLTT NCSGKGILSG HADGTIVRYF 180
FDDEGSGESQ GKLVNHPCPP YALAWATNSI VAAGCDRRIV AYGKEGHVLQ TFDYSRDPNE 240
REFTTAAASP GGQSVVLGSY DRLRVLNWSP RRSVWEEAKP KEIANLYTVT ALAWKRDGSR 300
LCAGTLCGGV EQFDCCLRRS IYKNKFELTY VGPSQVIVKN LSSGTRVVLK SHYGYEVEEV 360
KILGKERYLV AHTSDTLLLG DLNTNRLSEV AWQGSGGNEK YFFENENVCM IFNAGELTLV 420
EYGSNDTLGS VRTEFMNPHL ISVRINERRQ RGMEDNKKLA YLVDIKTIAI VDLIGGYNIG 480
TISHDSRVDW LELNETGHKL LFRDRKLRLH LYDIESCTKT MILNFCSYVQ WVPGSDVLVA 540
QNRNSLCVWY NIEAPERVTM SSIRGDVIGL ERGGGKTEVM VTEGVTTVAY TLDEGLIEFG 600
TAIDDGNYTR ATAFLETLEM TPETEAMWKT LSKLALEARQ LHIAERCFSA LGHVAKARFL 660
HETNEIADQV SREYGGEGTD FYQVRARLAM LEKNYKLAEM IFLEQNAVEE AMDMYQELHR 720
WDECIAVAQA KGHPALEKLR RGYYQWLMDT QQEERAGELQ ESQGDGLAAI SLYLKAGLPA 780
KAARLVLARE ELLANTELVE HITAALVKGE LYERAGDLFE KIQNPQRALE CYCKGNAFMK 840
AVELARLAFP VEVVRLEEAW GDHLVQQKQL DAAINHYIEA RCSIKAIEAA LGARQWKKAI 900
YILDLQDQNT ASKYYPRVAQ HYASLQEYEI AEELYIKGDQ TKDAIDMYTQ AGRWEQAHKL 960
AVKCMRPEDV SVLYITQAQE MEKQGKYREA ERLYVTVEEP DLAITMFKKH KLYEDMIRLV 1020
GKHHPDLLSD THLHLGKELE AEGRLQEAEY HYLEAQEWKA TVNMYRSSGL WEEAYRVAKA 1080
HGEANAHKHV AYLWAKSLGG ESAVRLLNKL GLLEAAIDHA ADNCSFEFAF ELSRLALKHK 1140
TPEIHLRYAM YLEDEGKFEE AEAEFIRAGK PKEAVLMFFH NQDWEAAQRV AEAHDPDSVA 1200
EVLLRQAREA LEEKDFQKAE GLLLRAQRPG LALNYYKEAG LWSDALRICK DYVPGQLEAL 1260
QEEYEREATK KGARGLEGLV EQARQWEQAG EYGRAVDCYL KVRDSSSGSL MEKCWMKAAE 1320
LAIKFLPPQR SLEVVQAVGP QLIGIGKHSA AAELYLNLDL VKEAIDAFIE GEEWNKAKRV 1380
AKELDPRYED YVDQHYKEFL KNQGKVDSLV GVDVVAALDL YVEQGQWDKC IETATKQNYK 1440
ILHKYVALYA THLIREGGYG QALALYVQHG APANPQNFNI YKRIFTDMVS SPGTNSAEAY 1500
HNWADLRDVL FNLCENLVKS SEVNTPAHEE FETMLLIAHY YATRSAAQSV KQLETVAARL 1560
SVSLLRHTQL LPADKAFYEA GIAAKAVGWE NMAFIFLNRF LDLTDAIEEG TLDALDHSDF 1620
QDTDIPFEVP LPAKQHVPEA QREEVRDWVL TVSMDQRLEQ VLPRDERGAY EASLVAVSTG 1680
VRALPCLITG YPILRNKIEF KRPGKAANKD NWNKFLMAIK TSHSPVCQDV LKFISQWCGG 1740
LPSTSFSFQ 1749

Abbreviation :
CLO : cleft lip only. CPO : cleft palate only. CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.

Protein disorder information

Orthologous information

Relation Gene symbol Entrez ID UniProt ID Cleft type Developmental stage Species Evidence Details
1:1 orthologIFT172483013E2RF25Canis lupus familiarisPredictionMore>>
1:1 orthologIFT172A0A452EH68Capra hircusPredictionMore>>
1:1 orthologIFT17226160Q9UG01Homo sapiensPredictionMore>>
1:1 orthologIft17267661Q6VH22CPOMus musculusPublicationMore>>
1:1 orthologIFT172459104K7B8Z3Pan troglodytesPredictionMore>>
1:1 orthologIFT172100348467G1SLK9Oryctolagus cuniculusPredictionMore>>
1:1 orthologift172432389Q5RHH4Danio rerioPredictionMore>>

Gene ontology

GO ID GO Term
GO:0005930 axoneme
GO:0036064 ciliary basal body
GO:0030992 intraciliary transport particle B
GO:0097598 sperm cytoplasmic droplet
GO:0097225 sperm midpiece
GO:0097228 sperm principal piece
GO:0060348 bone development
GO:0007420 brain development
GO:0031122 cytoplasmic microtubule organization
GO:0009953 dorsal/ventral pattern formation
GO:0048596 embryonic camera-type eye morphogenesis
GO:0008544 epidermis development
GO:0001947 heart looping
GO:0061525 hindgut development
GO:0042073 intraciliary transport
GO:0070986 left/right axis specification
GO:0060173 limb development
GO:0050680 negative regulation of epithelial cell proliferation
GO:0045879 negative regulation of smoothened signaling pathway
GO:0001843 neural tube closure
GO:1905515 non-motile cilium assembly
GO:0007219 Notch signaling pathway
GO:0045880 positive regulation of smoothened signaling pathway
GO:0016485 protein processing
GO:0060021 roof of mouth development
GO:0007224 smoothened signaling pathway
GO:0021522 spinal cord motor neuron differentiation

Functional annotations

Keywords

Keyword ID Keyword Term
KW-0175 Coiled coil
KW-1185 Reference proteome

Interpro

InterPro ID InterPro Term
IPR016024 ARM-type_fold
IPR011990 TPR-like_helical_dom_sf
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR036322 WD40_repeat_dom_sf

PROSITE

PROSITE ID PROSITE Term

Pfam

Pfam ID Pfam Term
PF00400 WD40