| Tag | Content |
|---|---|
| Uniprot ID | E2RS36 |
| Entrez ID | 479437 |
| Genbank protein ID | |
| Genbank nucleotide ID | XM_005619763.2 |
| Ensembl protein ID | ENSCAFP00000020579 |
| Ensembl nucleotide ID | ENSCAFG00000013963 |
| Gene name | Beta-carotene oxygenase 2 |
| Gene symbol | BCO2 |
| Organism | Canis lupus familiaris |
| NCBI taxa ID | 9615 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | |
| Sequence | MFSQTFLHFV SNLSTIAVGF LSVVVHWIPV LKKYMEGTHQ KKAVFHKRER LPCIAPLLTT 60 VEEMPQMVSA QVRGQFPEWL SGYLLRIGPG KFEFGKDEYS HWFDGMALLH QFRMEKGTVT 120 YRSKFLQSDT YKANSAHDRI VISEFGTLAL PDPCKNVFER FMSKFELPAI TDNTNVNYVQ 180 YKGDYYVSTE TNFMNKVDIK TLEKTEKVDW SKFIAVNGAT AHPHYDPDGT AYNMGNSYGP 240 HGSCYNVIQI PPEKVDLGET VHGAQVICSI ASAERMKPSY YHSFGMTRNY IIFIEQPLKM 300 NLWKIVTSRI RGKAFSDGIS WEPQYNTRFH VVDKHTGQLL PGMYYTKPFV TFHQINAFED 360 QGCVVIDLCC QDDGRSLEVY QLQNLRKAGE GLDQVYNSVG RSFPRRFVLP LHVSLNDPEG 420 ENLSPLSYSS ASAVKHADGK IWCAYENLHP EDLEEEGGVE FPQINYGQFS GKKYRFFYGC 480 GFRHLVGDSL IKVDVVNKTL TIWREDGFYP SEPVFVPAPG TREEDGGVIL SVVITPDQNE 540 NNFLLVLDAK NFEELGRAEV PVRMPYGFHG TFVAT 575 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | BCO2 | 479437 | E2RS36 | Canis lupus familiaris | Prediction | More>> | ||
| 1:1 ortholog | BCO2 | A0A452E744 | Capra hircus | Prediction | More>> | |||
| 1:1 ortholog | BCO2 | 83875 | Q9BYV7 | Homo sapiens | Prediction | More>> | ||
| 1:1 ortholog | Bco2 | 170752 | Q99NF1 | CPO | Mus musculus | Publication | More>> | |
| 1:1 ortholog | BCO2 | 451548 | H2R4A4 | Pan troglodytes | Prediction | More>> | ||
| 1:1 ortholog | BCO2 | 100344631 | G1SXN4 | Oryctolagus cuniculus | Prediction | More>> | ||
| 1:1 ortholog | Bco2 | 315644 | A3KN98 | Rattus norvegicus | Prediction | More>> |
| GO ID | GO Term |
|---|---|
| GO:0016021 | integral component of membrane |
| GO:0005739 | mitochondrion |
| GO:0003834 | beta-carotene 15,15'-monooxygenase activity |
| GO:0010436 | carotenoid dioxygenase activity |
| GO:0046872 | metal ion binding |
| GO:0004744 | retinal isomerase activity |
| GO:0016121 | carotene catabolic process |
| GO:0051881 | regulation of mitochondrial membrane potential |
| GO:2000377 | regulation of reactive oxygen species metabolic process |
| GO:0042574 | retinal metabolic process |
| GO:0016122 | xanthophyll metabolic process |
| InterPro ID | InterPro Term |
|---|---|
| IPR004294 | Carotenoid_Oase |
| Pfam ID | Pfam Term |
|---|---|
| PF03055 | RPE65 |