| Tag | Content |
|---|---|
| Uniprot ID | H2R4A4 |
| Entrez ID | 451548 |
| Genbank protein ID | |
| Genbank nucleotide ID | XM_016921986.1 |
| Ensembl protein ID | ENSPTRP00000046809 |
| Ensembl nucleotide ID | ENSPTRG00000023726 |
| Gene name | Beta-carotene oxygenase 2 |
| Gene symbol | BCO2 |
| Organism | Pan troglodytes |
| NCBI taxa ID | 9598 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | |
| Sequence | MFFRVFLHFI RSHSATAVDF LPVMVHRLPV FKRYMGNTPQ KKAVFGQCRG LPCVAPLLTT 60 VEEAPRGISA RVCGHFPKWL NGSLLRIGPG KFEFGKDKYN HWFDGMALLH QFRMAKGTVT 120 YRSKFLQSDT YKANSAKNRI VISEFGTLAL PDPCKNVFER FMSRFELPGK AAGFSYKVIR 180 VPPEKVDLGE TIHGAQVICS IASTEKGKPS YYHSFGMTRN YIIFIEQPLK MNLWKIATSK 240 IRGKAFSDGI SWEPQCNTRF HVVEKRSGQL LPGRYYSKPF VTFHQINAFE DQGCVIIDLC 300 CQDNGRTLEV YQLQNLRKAG EGLDQVHNSA AKSFPRRFVL PLNVSLNAPE GDNLSPLSYT 360 SASAVKQADG TIWCSHENLH QEDLEKEGGI EFPQIYYDRF SGKKYHFFYG CGFRHLVGDS 420 LIKVDVVNKT LKVWREDGFY PSEPVFVPAP GTNEEDGGVI LSVVITPNQN ESNFLLVLDA 480 KNFEELGRAE VPVQMPYGFH GTFIPI 506 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | BCO2 | 479437 | E2RS36 | Canis lupus familiaris | Prediction | More>> | ||
| 1:1 ortholog | BCO2 | A0A452E744 | Capra hircus | Prediction | More>> | |||
| 1:1 ortholog | BCO2 | 83875 | Q9BYV7 | Homo sapiens | Prediction | More>> | ||
| 1:1 ortholog | Bco2 | 170752 | Q99NF1 | CPO | Mus musculus | Publication | More>> | |
| 1:1 ortholog | BCO2 | 451548 | H2R4A4 | Pan troglodytes | Prediction | More>> | ||
| 1:1 ortholog | BCO2 | 100344631 | G1SXN4 | Oryctolagus cuniculus | Prediction | More>> | ||
| 1:1 ortholog | Bco2 | 315644 | A3KN98 | Rattus norvegicus | Prediction | More>> |
| GO ID | GO Term |
|---|---|
| GO:0005739 | mitochondrion |
| GO:0003834 | beta-carotene 15,15'-monooxygenase activity |
| GO:0010436 | carotenoid dioxygenase activity |
| GO:0046872 | metal ion binding |
| GO:0004744 | retinal isomerase activity |
| GO:0016121 | carotene catabolic process |
| GO:0051881 | regulation of mitochondrial membrane potential |
| GO:2000377 | regulation of reactive oxygen species metabolic process |
| GO:0042574 | retinal metabolic process |
| GO:0016122 | xanthophyll metabolic process |
| InterPro ID | InterPro Term |
|---|---|
| IPR004294 | Carotenoid_Oase |
| Pfam ID | Pfam Term |
|---|---|
| PF03055 | RPE65 |