| Tag | Content |
|---|---|
| Uniprot ID | E2RSV3 |
| Entrez ID | 488934 |
| Genbank protein ID | |
| Genbank nucleotide ID | XM_546051.3 |
| Ensembl protein ID | ENSCAFP00000013388 |
| Ensembl nucleotide ID | ENSCAFG00000009102 |
| Gene name | Betaine--homocysteine S-methyltransferase 2 |
| Gene symbol | BHMT2 |
| Organism | Canis lupus familiaris |
| NCBI taxa ID | 9615 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | Involved in the regulation of homocysteine metabolism. |
| Sequence | MAPVGGPGAK KGILERLDSG EVVVGDGSFL ITLEKRGYVK AGLWTPEAIV DHPDAVRQLH 60 MEFLRAGSNV MQTFTFSASE DNMGSKWEDV NAAACDLARE VAGKGDALVA GGISQTSVYR 120 HHKDEARVKK LFQLQLEVFI RKNVDFLIAE YFEHAEEAVW AVEVLKESGK PVAVTMCIGP 180 DGDMCGVKPG ECAVKLVKAG AAIVGVNCRF GPSTSLKTMK LMKEGLQAAG LQAHLIVQSL 240 GFHTPDCGKG GVVDLPEYPF GLEPRVATRW DIQKYAREAY NLGVRYIGGC CGFEPYHIRA 300 IAEELAPERG FLPPASEKHG SWGSGLNMHT KPWIRARARR EYWENLLPAS GRPFCPSLSQ 360 PDA 363 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | BHMT2 | 488934 | E2RSV3 | Canis lupus familiaris | Prediction | More>> | ||
| 1:1 ortholog | BHMT2 | A0A452GA59 | Capra hircus | Prediction | More>> | |||
| 1:1 ortholog | BHMT2 | 23743 | Q9H2M3 | Homo sapiens | Publication | More>> | ||
| 1:1 ortholog | Bhmt2 | 64918 | Q91WS4 | Mus musculus | Prediction | More>> | ||
| 1:1 ortholog | BHMT2 | A0A2I3TLY8 | Pan troglodytes | Prediction | More>> | |||
| 1:1 ortholog | bhmt-2 | 100523776 | E7D6R3 | Sus scrofa | Prediction | More>> | ||
| 1:1 ortholog | Bhmt2 | F1LMG2 | Rattus norvegicus | Prediction | More>> |
| GO ID | GO Term |
|---|---|
| GO:0047150 | betaine-homocysteine S-methyltransferase activity |
| GO:0061627 | S-methylmethionine-homocysteine S-methyltransferase activity |
| GO:0008270 | zinc ion binding |
| GO:0071267 | L-methionine salvage |
| GO:0032259 | methylation |
| GO:0046500 | S-adenosylmethionine metabolic process |
| GO:0033477 | S-methylmethionine metabolic process |
| PROSITE ID | PROSITE Term |
|---|---|
| PS50970 | HCY |
| Pfam ID | Pfam Term |
|---|---|
| PF02574 | S-methyl_trans |