| Tag | Content |
|---|---|
| Uniprot ID | F1LRJ1 |
| Entrez ID | 363265 |
| Genbank protein ID | |
| Genbank nucleotide ID | XM_006245259.3 |
| Ensembl protein ID | ENSRNOP00000020669 |
| Ensembl nucleotide ID | ENSRNOG00000015365 |
| Gene name | Collagen type IV alpha 3 chain |
| Gene symbol | Col4a3 |
| Organism | Rattus norvegicus |
| NCBI taxa ID | 10116 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | |
| Sequence | MHSETAPRFL ALLLPILLLL LAAPPVVSKG CVCEGKGKCL CWGTKGEKGE IGFPGPPGFP 60 GQKGFPGPEG LPGPQGPKGS PGLPGLTGPK GIRGITGLPG FAGPPGLPGI PGYPGPPGLA 120 GLPGCNGSKG EQGFPGIPGT PGYAGLPGPD GLKGQKGKPA QGEDGEFNGK GDPGPPGAPG 180 FQGLPGPPGF PGPAGPPGPP GFFGFPGAMG PRGPKGRMGD STIGQEGEKG VKGLTGPPGL 240 PGPVIFTLRH PYRKSDFQGQ KGDEGERGEP GPPGPSGPPG DSYGSEKGAP GEPGPRGKPG 300 KDGAPGFPGT EGAKGTRGFP GLRGEAGIKG WKGDIGPPGF PGPTEECYDA HLQKGDKGMP 360 GPPGPKGVRG PRGPSGPPGV PGSPGPSRPG LRGPVGWPGL KGSKGERGPP GIDTVGPPGS 420 LGCPGSPGPP GPPGPPGRPG DTVFQPGPPG DHGAPGDIGP PGVPGVDGPK GEPGQPCTEC 480 HCIPGPPGVP GVPGLDGVKG IPGGRGAPGV KGNPGSPGNA GLPGFAGFPG DQGHPGLKGD 540 KGDTPLPWGQ VGDPGDPGHR GLPGRKGFDG SPGGPGAKGP RGPRGEPALS GRKGDQGPPG 600 APGSPGPPGP AGPAGPPGYG PQGEPGPKGA QGVPGALGPP GEAGLKGESS ASIPVLGPPG 660 PPGPPGQAGP RGLPGLPGPV GTCDPGHPGP DGEPGIPEVG FPGARGPKGD QGFPGTIGLP 720 GYPGETGRPG YPGEMGVPGA KGEPSVGRPG EPGKPGFPGE RGNSGENGDI GLPGLPGPPG 780 TPGKDGFDGP PGDPGQSGPP GAKGPPGRCI PGPRGTQGLP GLNGLKGQPG RRGDTGPKGD 840 PGIPGMDRSG VPGERGPPGT PGLPGEMGPP GQKGYPGPPG FPGLPGEKGE VGIMGYPGTT 900 GLPGLPGKPG SQGQRGNLGI PGVKGERGRP GVKGERGEKG KPGPPHAPHL KGDKGEPGLK 960 GFVGNPGEKG NRGNPGLPGP KGLEGVPGLP GSPGPRGDTG SSGDPGRPGP QGLPGSMGNM 1020 GVPGPKGRKG TSGFPGVAGR PGLPGIPGPQ GDKGEPGYSE GASPGPPGPK GDPGLPGDKG 1080 KKGERGLPGP PGHSGPAGPD GAPGSPGSPG HPGRPGPDGD SGLKGQKGFP GPPGSTGPPG 1140 PPGLPGLPGP MGMRGDQGQD GIPGPPGEKG ETGLLGAHPG QKGSPGVPGV KGDRGVPGLS 1200 GLPGRKGTMG DVGPQGPPGT TGLPGPPGLP GTIVPGPKGN RGLPGLRGNP GEPGPPGPPG 1260 PVGEGIKGDK GFMGLPGSRG LPGMVGDTGA PGQPGAPGIP GLPGVRGDPG FPGFPGVKGE 1320 KGNPGFLGSI GHPGPVGPKG PPGPQGKPGT LKVISLPGSP GPPGAPGQPG VKGDPGPLGP 1380 PGIPGPCGPR GQPGKDGKPG APGPPGVKGS KGSKGEQGPP GLDGLPGLKG KPGDRGTPAN 1440 GTRMRGFIFT RHSQTTANPS CPEGTQPLYS GFSLLFVQGN EHAHGQDLGT LGSCLQRFTT 1500 MPFLFCNVDN VCNFASRNDY SYWLSTPAPM PMDMAPITGR ALEPYVSRCT VCEGPAMAIA 1560 VHSQTTAIPP CPQGWVSLWK GFSFVMFTSA GSEGAGQALA SPGSCLEEFR ASPFIECHGR 1620 GTCNYYSNSY SFWLASLNPE RMFRKPIPST VKAGDLEKII SRCQVCMKKR H 1671 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | COL4A3 | F1MZU6 | Bos taurus | Prediction | More>> | |||
| 1:1 ortholog | COL4A3 | 1285 | Q01955 | CPO,CL/P | Homo sapiens | Publication | More>> | |
| 1:1 ortholog | Col4a3 | 12828 | Q9QZS0 | Mus musculus | Prediction | More>> | ||
| 1:1 ortholog | COL4A3 | 459988 | H2QJJ5 | Pan troglodytes | Prediction | More>> | ||
| 1:1 ortholog | COL4A3 | G1SCM1 | Oryctolagus cuniculus | Prediction | More>> | |||
| 1:1 ortholog | Col4a3 | 363265 | F1LRJ1 | Rattus norvegicus | Prediction | More>> |
| GO ID | GO Term |
|---|---|
| GO:0005604 | basement membrane |
| GO:0005587 | collagen type IV trimer |
| GO:0005783 | endoplasmic reticulum |
| GO:0031012 | extracellular matrix |
| GO:0005615 | extracellular space |
| GO:0005201 | extracellular matrix structural constituent |
| GO:0005178 | integrin binding |
| GO:0006919 | activation of cysteine-type endopeptidase activity involved in apoptotic process |
| GO:0007166 | cell surface receptor signaling pathway |
| GO:0038063 | collagen-activated tyrosine kinase receptor signaling pathway |
| GO:0072577 | endothelial cell apoptotic process |
| GO:0030198 | extracellular matrix organization |
| GO:0032836 | glomerular basement membrane development |
| GO:0016525 | negative regulation of angiogenesis |
| GO:1905563 | negative regulation of vascular endothelial cell proliferation |
| GO:0009749 | response to glucose |
| PROSITE ID | PROSITE Term |
|---|---|
| PS51403 | NC1_IV |