| Tag | Content |
|---|---|
| Uniprot ID | H2QJJ5; A0A2J8NFK1; |
| Entrez ID | 459988 |
| Genbank protein ID | |
| Genbank nucleotide ID | XM_516130.6 |
| Ensembl protein ID | ENSPTRP00000022211 |
| Ensembl nucleotide ID | ENSPTRG00000012992 |
| Gene name | Collagen type IV alpha 3 chain |
| Gene symbol | COL4A3 |
| Organism | Pan troglodytes |
| NCBI taxa ID | 9598 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | |
| Sequence | MSARTAPGPQ VLLLPLLLVL LAAAPVASKG CVCKDKGQCF CDGAKGEKGE KGFPGPPGSP 60 GQKGFTGPEG LPGPQGPKGF PGLPGLTGSK GVRGISGLPG FSGSPGLPGT PGNTGPYGLV 120 GVPGCSGSKG EQGFPGLPGT PGYPGIPGAA GLKGQKGAPA KGEDIELDAK GDPGLPGAPG 180 PQGLPGPPGF PGPVGPPGPP GFFGFPGAMG PRGPKGHMGE RVIGHKGERG VKGLTGPPGP 240 PGTVIVTLTG PDNRTDLKGE KGDKGAMGEP GPPGPSGLPG ESYGSEKGAP GDPGPQGKPG 300 KDGVPGFPGS EGVKGNRGFP GLMGEDGIKG QKGDIGPPGF RGPTEYYDTY QEKGEEGTPG 360 PPGPRGARGP QGPSGPPGVP GSPGSSRPGL RGAPGWPGLK GSKGERGRPG KDAMGTPGSP 420 GCAGSPGLPG SPGPPGPPGD IVFRKGPPGD RGLPGYLGSP GIPGVDGPKG EPGLLCTQCP 480 YIPGPPGLPG LPGLHGVKGI PGRQGAAGLK GSPGSPGNTG LPGFPGFPGA QGDPGLKGEK 540 GETLQPEGQV GAPGDPGLRG QPGRKGLDGI PGTPGVKGLP GPKGELALSG EKGDQGPPGD 600 PGSPGSPGPA GPAGPPGYGP QGEPGPQGTQ GVPGAPGPPG EAGPRGELSV STPVPGLPGP 660 PGPPGHPGPQ GPPGIPGSLG KCGDPGLPGP DGEPGIPGIG FPGPPGPKGD KGFPGTKGSL 720 GCPGKMGEPG LPGKPGLPGA KGEPAVAMPG GPGTPGFPGE RGNSGEHGEI GLPGLPGLPG 780 TPGNEGLDGP RGDPGQPGPP GEQGPPGRCI EGPRGAQGLP GLNGLKGQQG RRGKTGPKGD 840 PGIPGLDRSG FPGETGSPGM PGHQGEMGPP GQRGYPGNPG ILGPPGEDGV IGMMGFPGAI 900 GPPGPPGNPG TPGQRGSPGI PGVKGQRGTP GAKGEQGDKG NPGPSEISHV IGDKGEPGLK 960 GFAGNPGEKG NRGVPGMPGL KGLKGLPGPA GPPGPRGDLG STGNPGEPGL RGIPGIMGNM 1020 GMPGSKGKRG TLGFPGRAGR PGLPGIHGLQ GDKGEPGYSE GTRPGPPGPT GDPGLPGDMG 1080 KKGEMGQPGP PGHLGPAGPE GAPGSPGSPG LPGKPGPHGD LGFKGIKGLL GPPGIRGPPG 1140 LPGFPGSPGP MGIRGDQGRD GIPGPAGEKG ETGLLRAPPG PRGNPGAQGA KGDRGAPGFP 1200 GLPGRRGAMG EAGPRGPTGI EGFPGPPGLP GAIIPGQTGN RGPPGSRGSP GEPGPPGPPG 1260 SHVIGIKGDK GSMGHPGLKG PPGTAGDMGP PGRLGAPGTP GLPGPRGDPG FQGFPGVKGE 1320 KGNPGFLGSI GPPGPIGPKG LPGVRGDPGT LKIISLPGSP GPPGTPGEPG MQGEPGPPGP 1380 PGNLGPCGPR GKPGKDGKPG TPGPAGEKGN KGSKGEPGPA GSDGLPGLKG KRGDSGSPAT 1440 WTTRGFVFTR HSQTTAIPSC PEGTVPLYSG FSFLFVQGNQ QAHGQDLGTL GSCLQRFTTM 1500 PFLFCNVNDV CNFASRNDYS YWLSTPALMP MNMAPITGRA LEPYISRCTV CEGPAIAIAV 1560 HSQTTDIPPC PHGWISLWKG FSFIMFTSAG SEGTGQALAS PGSCLEEFRA SPFLECHGRG 1620 TCNYYSNSYS FWLASLNPER MFRKPIPSTV KAGELEKIIS RCQVCMKKRH |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | COL4A3 | F1MZU6 | Bos taurus | Prediction | More>> | |||
| 1:1 ortholog | COL4A3 | 1285 | Q01955 | CPO,CL/P | Homo sapiens | Publication | More>> | |
| 1:1 ortholog | Col4a3 | 12828 | Q9QZS0 | Mus musculus | Prediction | More>> | ||
| 1:1 ortholog | COL4A3 | 459988 | H2QJJ5 | Pan troglodytes | Prediction | More>> | ||
| 1:1 ortholog | COL4A3 | G1SCM1 | Oryctolagus cuniculus | Prediction | More>> | |||
| 1:1 ortholog | Col4a3 | 363265 | F1LRJ1 | Rattus norvegicus | Prediction | More>> |
| GO ID | GO Term |
|---|---|
| GO:0005587 | collagen type IV trimer |
| GO:0005783 | endoplasmic reticulum |
| GO:0031012 | extracellular matrix |
| GO:0005615 | extracellular space |
| GO:0005201 | extracellular matrix structural constituent |
| GO:0005178 | integrin binding |
| GO:0006919 | activation of cysteine-type endopeptidase activity involved in apoptotic process |
| GO:0038063 | collagen-activated tyrosine kinase receptor signaling pathway |
| GO:0072577 | endothelial cell apoptotic process |
| GO:0030198 | extracellular matrix organization |
| GO:0032836 | glomerular basement membrane development |
| GO:0016525 | negative regulation of angiogenesis |
| GO:1905563 | negative regulation of vascular endothelial cell proliferation |
| Keyword ID | Keyword Term |
|---|---|
| KW-1185 | Reference proteome |
| PROSITE ID | PROSITE Term |
|---|---|
| PS51403 | NC1_IV |