| Tag | Content |
|---|---|
| Uniprot ID | F1MZU6 |
| Entrez ID | |
| Genbank protein ID | |
| Genbank nucleotide ID | |
| Ensembl protein ID | ENSBTAP00000028418 |
| Ensembl nucleotide ID | ENSBTAG00000021316 |
| Gene name | Collagen alpha-3(IV) chain |
| Gene symbol | COL4A3 |
| Organism | Bos taurus |
| NCBI taxa ID | 9913 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | |
| Sequence | MRPRTAPRPP ALLLTLLLVL LVAAPTEGKG CICKDKGQCF CDGAKGEKGE KGFPGPPGPP 60 GQKGYPGPEG LPGPQGPKGS PGSPGLTGAK GVRGITGLPG FSGPPGLPGI PGHPGPYGLA 120 GLPGCNGSRG EPGFPGLRGT PGYPGIPGVI GLKGEKGAPA EGEGVGLDGK GDPGLPGAPG 180 FQGLPGLPGF PGPAGPLGPP GFLGFPGTMG PPGPKGHMGD NVLGQKGERG VKGLTGPPGP 240 PGTVIVTLTG PDNRTDLKGE KGDLGAMGQS GPPGPSGPPG ESYGSEKGAP GEPGPQGKPG 300 KDGAPGFPGT EGAKGDRGFP GLRGEDGIKG WKGNSGPPGF RGPTEYYDAY QEKGDEGIPG 360 LPGPKGARGP QGPSGPPGAP GSPGSSRPGL QGAPGVPGVK GSKGEQGPPG KTAAGLPGSP 420 GCPGSPGPMG FPGPPGPPGG IVFREGPPGV GGLPGHIGSP GIPGVGGPKG EPGLLCTQCP 480 CIPGSPGPPG FPGLEGEKGF QGEPGAAGIK GSPGSPGSAG LPGFPGFPGA QGQPGLKGEK 540 GETPRPEGEV GAPGDPGLQG HPGRKGLDGI PGTPGVKGLP GPKGEPALSG EKGDPGLPGD 600 PGIPGSPGPI GPAGPSDYGP QGEPGPKGAQ GLPGAPGPPG EAGPEGETGV STPVPGLPGP 660 PGPPGRAGPR GPPGIPGSTG ECDLGLPGPD GEPGIPEIGF PGPPGPKGDR GFPGAKGSPG 720 CPGEMGKPGL PGKPGLPGIK GEPGLAMPGE PGAPGLPGER GSSGENGEIG LPGLPGLPGV 780 PGTGGLDGPR GDPGKPGPPG ERGPPGRCTE GPRGTQGLPG LNGLKGQQGR RGETGPKGDP 840 GIPGLDRSGF PGEPGLPGMP GHRGEMGPPG PKGYPGNPGF LGPPGEKGIM GMMGFPGNIG 900 PPGPPGSPGT PGQKGSFGIP GVKGARGPPG AQGEQGERGT PGSPQIFHLV GDKGEPGLKG 960 LAGKPGEKGN RGIPGFPGIK GLSGLPGPPG PPGPRGEPGS IGNPGEPGPR GTPGSMGNMG 1020 VPGTKGMKGT VGFPGLAGSP GLPGIHGLQG DKGEPGYSEG ARPGPPGPKG DPGLPGDMGK 1080 KGERGPPGAP GRSGPAGPEG LPGSPGPPGH PGKSGPGGDL GSKGIKGFPG FPGTKGPPGP 1140 PGLPGNPGPV GERGNQGLDG IPGPAGEKGE TGLLGAPPGP RGKPGPQGTK GDRGAPGLPG 1200 LPGRKGPVGD AGPPGPIGVT GPQGAPGFPG VTIPGQKGDR GPPGSRGNPG MPGPPGPPGS 1260 PVEGIKGDKG LMGEPGQRGP PGAIGDMGSP GHPGAPGVPG QPGARGDPGF YGFPGMKGEK 1320 GNSGFPGPPG PPGQSGPKGP PGVRGEPGTV KIISLPGSPG PPGSAGEPGM QGEPGPPGPP 1380 GDPGPCGPKG KPGEDGPPGT PGPTGEKGNK GSKGEQGPPG SDGLPGLKGK PGDTGPPAAG 1440 AVMRGFVFTR HSQTTAIPSC PEGTEPLYSG FSLLFVQGNE QAHGQDLGTL GSCLQRFTTM 1500 PFLFCNINDV CNFASRNDYS YWLSTPAMIP MDMAPITGRA LEPYISRCTV CEGPAIAIAV 1560 HSQTTDIPPC PAGWISLWKG FSFIMFTSAG SEGAGQALAS PGSCLEEFRA SPFIECHGRG 1620 TCNYYSNSYS FWLASLDPKR MFRKPIPSTV KAGELENIIS RCQVCMKMRP |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | COL4A3 | F1MZU6 | Bos taurus | Prediction | More>> | |||
| 1:1 ortholog | COL4A3 | 1285 | Q01955 | CPO,CL/P | Homo sapiens | Publication | More>> | |
| 1:1 ortholog | Col4a3 | 12828 | Q9QZS0 | Mus musculus | Prediction | More>> | ||
| 1:1 ortholog | COL4A3 | 459988 | H2QJJ5 | Pan troglodytes | Prediction | More>> | ||
| 1:1 ortholog | COL4A3 | G1SCM1 | Oryctolagus cuniculus | Prediction | More>> | |||
| 1:1 ortholog | Col4a3 | 363265 | F1LRJ1 | Rattus norvegicus | Prediction | More>> |
| GO ID | GO Term |
|---|---|
| GO:0005587 | collagen type IV trimer |
| GO:0005783 | endoplasmic reticulum |
| GO:0031012 | extracellular matrix |
| GO:0005615 | extracellular space |
| GO:0005201 | extracellular matrix structural constituent |
| GO:0005178 | integrin binding |
| GO:0006919 | activation of cysteine-type endopeptidase activity involved in apoptotic process |
| GO:0038063 | collagen-activated tyrosine kinase receptor signaling pathway |
| GO:0072577 | endothelial cell apoptotic process |
| GO:0030198 | extracellular matrix organization |
| GO:0032836 | glomerular basement membrane development |
| GO:0016525 | negative regulation of angiogenesis |
| GO:1905563 | negative regulation of vascular endothelial cell proliferation |
| PROSITE ID | PROSITE Term |
|---|---|
| PS51403 | NC1_IV |