| Tag | Content |
|---|---|
| Uniprot ID | F1PGH2 |
| Entrez ID | |
| Genbank protein ID | |
| Genbank nucleotide ID | |
| Ensembl protein ID | ENSCAFP00000000683 |
| Ensembl nucleotide ID | ENSCAFG00000000462 |
| Gene name | Tryptophan hydroxylase 2 |
| Gene symbol | TPH2 |
| Organism | Canis lupus familiaris |
| NCBI taxa ID | 9615 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | |
| Sequence | MQPAMMMFSS KYWAKRGFSL DSAVPEDHQL LGSLTLNRAN SGKNDDKKGD NGDSKSEASP 60 ESGKTAVVFS LKNEVGGLVK VLNLFQEKHV NMLHIESRKS RRRSSEVEIF VDCECGQTEF 120 SELVQLLKSQ STVVMPNPPA SIWAEGEELD DVPWFPRKIS ELDRCSHRVL MYGSELDADH 180 PGFKDDVYRQ RRKYFVDVAM GYKYGQPIPR VQYTAEETRT WGVVFRELCK LYPTHACREH 240 LDNLPLLTQH CGYREDNVPQ LQDVSAFLRE RSGFTVRPVA GYLSPRDFLA GLAYRVFHCT 300 QYVRHGSDPL YTPEPDTCHE LLGHVPLLAD PKFAQFSQEI GLASLGASDE DVQKLATCYF 360 FTIEFGLCKQ EGQLRAYGAG LLSSIGELKH ALSDKACVKA FDPKTTCLQE CLITTFQDAY 420 FVSESFEEAK EKMRDFAKSI TRPFSVHFNP YTQSIEILKD TRSIENVVQD LRGDLNTVCD 480 ALNKMNQYLG I 491 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | TPH2 | F1PGH2 | Canis lupus familiaris | Prediction | More>> | |||
| 1:1 ortholog | TPH2 | 102174722 | A0A452DPA3 | Capra hircus | Prediction | More>> | ||
| 1:1 ortholog | TPH2 | 100009684 | Q0EAB8 | Equus caballus | Prediction | More>> | ||
| 1:1 ortholog | TPH2 | 121278 | Q8IWU9 | Homo sapiens | Publication | More>> | ||
| 1:1 ortholog | Tph2 | 216343 | Q8CGV2 | Mus musculus | Prediction | More>> | ||
| 1:1 ortholog | TPH2 | 467070 | A0A2I3TG35 | Pan troglodytes | Prediction | More>> | ||
| 1:1 ortholog | TPH2 | F1SH22 | Sus scrofa | Prediction | More>> | |||
| 1:1 ortholog | Tph2 | 317675 | Q8CGU9 | Rattus norvegicus | Prediction | More>> | ||
| 1:1 ortholog | tph2 | 407712 | Q1LUE3 | Danio rerio | Prediction | More>> |
| GO ID | GO Term |
|---|---|
| GO:0043005 | neuron projection |
| GO:0005506 | iron ion binding |
| GO:0004510 | tryptophan 5-monooxygenase activity |
| GO:0009072 | aromatic amino acid family metabolic process |
| GO:0042427 | serotonin biosynthetic process |