| Tag | Content |
|---|---|
| Uniprot ID | Q0EAB8 |
| Entrez ID | 100009684 |
| Genbank protein ID | BAF32950.1 |
| Genbank nucleotide ID | NM_001081783.1 |
| Ensembl protein ID | ENSECAP00000011237 |
| Ensembl nucleotide ID | ENSECAG00000013175 |
| Gene name | Tryptophan 5-hydroxylase 2 |
| Gene symbol | TPH2 |
| Organism | Equus caballus |
| NCBI taxa ID | 9796 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | |
| Sequence | MQPAMMMFSS KYWARRGFSL DSAVPEEHQL LGNLTVNKSN SGKNDDKKGN KGSSRSETAP 60 DSGKTAVVFS LRNEVGGLVK ALKLFQEKHV NMVHIESRKS RRRSSEVEIF VDCECGKTEF 120 NELIQLLKFQ TTIVTLNPPE NIWTEEEELE DVPWFPRKIS ELDKCSHRVL MYGSELDADH 180 PGFKDNVYRQ RRKYFVDVAM SYKYGQPIPR VEYTEEETKT WGVVFRELSR LYPTHACQEY 240 LKNFPLLTKY CGYREDNVPQ LEDVSMFLKE RSGFAVRPVA GYLSPRDFLA GLAYRVFHCT 300 QYVRHSSDPL YTPEPDTCHE LLGHVPLLAD PKFAQFSQEI GLASLGASDE DVQKLATCYF 360 FTIEFGLCKQ EGQLRAYGAG LLSSIGELKH ALSDKACVKA FDPKTTCLQE CLITTFQEAY 420 FVSESFEEAK EKMREFAKSI TRPFSVHFNP YTQSVEVLKD SRSIESVVQD LRSDLNTVCD 480 ALNKMNQYLG V 491 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | TPH2 | F1PGH2 | Canis lupus familiaris | Prediction | More>> | |||
| 1:1 ortholog | TPH2 | 102174722 | A0A452DPA3 | Capra hircus | Prediction | More>> | ||
| 1:1 ortholog | TPH2 | 100009684 | Q0EAB8 | Equus caballus | Prediction | More>> | ||
| 1:1 ortholog | TPH2 | 121278 | Q8IWU9 | Homo sapiens | Publication | More>> | ||
| 1:1 ortholog | Tph2 | 216343 | Q8CGV2 | Mus musculus | Prediction | More>> | ||
| 1:1 ortholog | TPH2 | 467070 | A0A2I3TG35 | Pan troglodytes | Prediction | More>> | ||
| 1:1 ortholog | TPH2 | F1SH22 | Sus scrofa | Prediction | More>> | |||
| 1:1 ortholog | Tph2 | 317675 | Q8CGU9 | Rattus norvegicus | Prediction | More>> | ||
| 1:1 ortholog | tph2 | 407712 | Q1LUE3 | Danio rerio | Prediction | More>> |
| GO ID | GO Term |
|---|---|
| GO:0043005 | neuron projection |
| GO:0005506 | iron ion binding |
| GO:0004510 | tryptophan 5-monooxygenase activity |
| GO:0009072 | aromatic amino acid family metabolic process |
| GO:0042427 | serotonin biosynthetic process |
| Pfam ID | Pfam Term |
|---|---|
| PF00351 | Biopterin_H |