Gene: TPH2

Basic information

Tag Content
Uniprot ID Q0EAB8
Entrez ID 100009684
Genbank protein ID BAF32950.1
Genbank nucleotide ID NM_001081783.1
Ensembl protein ID ENSECAP00000011237
Ensembl nucleotide ID ENSECAG00000013175
Gene name Tryptophan 5-hydroxylase 2
Gene symbol TPH2
Organism Equus caballus
NCBI taxa ID 9796
Cleft type
Developmental stage
Data sources Homology search
Reference
Functional description
Sequence
MQPAMMMFSS KYWARRGFSL DSAVPEEHQL LGNLTVNKSN SGKNDDKKGN KGSSRSETAP 60
DSGKTAVVFS LRNEVGGLVK ALKLFQEKHV NMVHIESRKS RRRSSEVEIF VDCECGKTEF 120
NELIQLLKFQ TTIVTLNPPE NIWTEEEELE DVPWFPRKIS ELDKCSHRVL MYGSELDADH 180
PGFKDNVYRQ RRKYFVDVAM SYKYGQPIPR VEYTEEETKT WGVVFRELSR LYPTHACQEY 240
LKNFPLLTKY CGYREDNVPQ LEDVSMFLKE RSGFAVRPVA GYLSPRDFLA GLAYRVFHCT 300
QYVRHSSDPL YTPEPDTCHE LLGHVPLLAD PKFAQFSQEI GLASLGASDE DVQKLATCYF 360
FTIEFGLCKQ EGQLRAYGAG LLSSIGELKH ALSDKACVKA FDPKTTCLQE CLITTFQEAY 420
FVSESFEEAK EKMREFAKSI TRPFSVHFNP YTQSVEVLKD SRSIESVVQD LRSDLNTVCD 480
ALNKMNQYLG V 491

Abbreviation :
CLO : cleft lip only. CPO : cleft palate only. CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.

Protein disorder information

Orthologous information

Relation Gene symbol Entrez ID UniProt ID Cleft type Developmental stage Species Evidence Details
1:1 orthologTPH2F1PGH2Canis lupus familiarisPredictionMore>>
1:1 orthologTPH2102174722A0A452DPA3Capra hircusPredictionMore>>
1:1 orthologTPH2100009684Q0EAB8Equus caballusPredictionMore>>
1:1 orthologTPH2121278Q8IWU9Homo sapiensPublicationMore>>
1:1 orthologTph2216343Q8CGV2Mus musculusPredictionMore>>
1:1 orthologTPH2467070A0A2I3TG35Pan troglodytesPredictionMore>>
1:1 orthologTPH2F1SH22Sus scrofaPredictionMore>>
1:1 orthologTph2317675Q8CGU9Rattus norvegicusPredictionMore>>
1:1 orthologtph2407712Q1LUE3Danio rerioPredictionMore>>

Gene ontology

GO ID GO Term
GO:0043005 neuron projection
GO:0005506 iron ion binding
GO:0004510 tryptophan 5-monooxygenase activity
GO:0009072 aromatic amino acid family metabolic process
GO:0042427 serotonin biosynthetic process

Functional annotations

Keywords

Keyword ID Keyword Term
KW-0408 Iron
KW-0479 Metal-binding
KW-0503 Monooxygenase
KW-0560 Oxidoreductase
KW-0597 Phosphoprotein
KW-1185 Reference proteome
KW-0724 Serotonin biosynthesis

Interpro

InterPro ID InterPro Term
IPR002912 ACT_dom
IPR001273 ArAA_hydroxylase
IPR018301 ArAA_hydroxylase_Fe/CU_BS
IPR036951 ArAA_hydroxylase_sf
IPR036329 Aro-AA_hydroxylase_C_sf
IPR019774 Aromatic-AA_hydroxylase_C
IPR005963 Trp_5_mOase
IPR041904 TrpOH_cat
IPR019773 Tyrosine_3-monooxygenase-like

PROSITE

PROSITE ID PROSITE Term
PS51671 ACT
PS00367 BH4_AAA_HYDROXYL_1
PS51410 BH4_AAA_HYDROXYL_2

Pfam

Pfam ID Pfam Term
PF00351 Biopterin_H