| Tag | Content |
|---|---|
| Uniprot ID | Q1LUE3 |
| Entrez ID | 407712 |
| Genbank protein ID | |
| Genbank nucleotide ID | NM_214795.2 |
| Ensembl protein ID | ENSDARP00000102919 |
| Ensembl nucleotide ID | ENSDARG00000057239 |
| Gene name | Tryptophan 5-monooxygenase |
| Gene symbol | tph2 |
| Organism | Danio rerio |
| NCBI taxa ID | 7955 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | |
| Sequence | MTNSTLHPPW TSFNRIDERP DKEEQKSTHD LGKLAVIFSL KNEVGFLVKA LRLFQEKHVN 60 LAHIESRRSK RLTNEIEIYA ECNCTKKEFN ELVQHLKDHV NIVSYNTPQH VWSAETDCLD 120 CVCVLGGLPD GEGIPWFPQK ISELDQCSHR VLMYGSELDA DHPGFKDKVY RQRRKYFVEV 180 AMNYKFGQPI PRIEYTAEEV KTWGVVYREL TKLYPTHACR EYLKNLPLLT KHCGYREDNI 240 PQLEDVSLFL RERSGFTVRP VAGYLSPRDF LAGLAYRVFN CTQYIRHSTD PLYTPEPDTC 300 HELLGHVPLL ADPKFAQFSQ EIGLASLGAS DEDVQKLATC YFFTIEFGLC KQDGQLRVYG 360 AGLLSSIGEL RHALSDKATV KVFDPKTTCY QECLITTFQD VYFVSESFEE AKEKMREFAK 420 SIKRPFSVYY NPYTQSIDLL KDTRSIENVV QDLRSDLTTV CDALGKMNKY LGI 473 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | TPH2 | F1PGH2 | Canis lupus familiaris | Prediction | More>> | |||
| 1:1 ortholog | TPH2 | 102174722 | A0A452DPA3 | Capra hircus | Prediction | More>> | ||
| 1:1 ortholog | TPH2 | 100009684 | Q0EAB8 | Equus caballus | Prediction | More>> | ||
| 1:1 ortholog | TPH2 | 121278 | Q8IWU9 | Homo sapiens | Publication | More>> | ||
| 1:1 ortholog | Tph2 | 216343 | Q8CGV2 | Mus musculus | Prediction | More>> | ||
| 1:1 ortholog | TPH2 | 467070 | A0A2I3TG35 | Pan troglodytes | Prediction | More>> | ||
| 1:1 ortholog | TPH2 | F1SH22 | Sus scrofa | Prediction | More>> | |||
| 1:1 ortholog | Tph2 | 317675 | Q8CGU9 | Rattus norvegicus | Prediction | More>> | ||
| 1:1 ortholog | tph2 | 407712 | Q1LUE3 | Danio rerio | Prediction | More>> |
| GO ID | GO Term |
|---|---|
| GO:0043005 | neuron projection |
| GO:0005506 | iron ion binding |
| GO:0004510 | tryptophan 5-monooxygenase activity |
| GO:0009072 | aromatic amino acid family metabolic process |
| GO:1902036 | regulation of hematopoietic stem cell differentiation |
| GO:0042427 | serotonin biosynthetic process |
| Pfam ID | Pfam Term |
|---|---|
| PF00351 | Biopterin_H |